EADC Values in Diagnosis of Renal Lesions by 3.0 T Diffusion-Weighted Magnetic Resonance Imaging: Compared with the ADC Values

Zhang, Yuelang; Yu, Byron M.; Ren, Juan; Qu, Kai; Wang, Ke; Qiang, Yan; Li, Chenxia; Sun, Xiaobai

doi:10.1007/s00723-012-0376-z

Cited by 22 publications

(15 citation statements)

References 33 publications

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“…The present study demonstrated that the ADC in renal cell carcinoma is lower than that in renal angiomyolipoma, which is consistent with the results of studies by Doğanay et al (18), Mytsyk et al (19) and Zhang et al (20), which found that the ADC was lower in malignant kidney tumors than in benign tumors. -3 mm 2 /sec for renal angiomyolipoma.…”

Section: Discussionsupporting

confidence: 93%

Diagnostic utility of diffusion-weighted magnetic resonance imaging in two common renal tumors

2015

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Abstract. The aim of the present study was to evaluate the utility of diffusion-weighted magnetic resonance imaging (DWI) in the diagnosis of common renal tumors. Conventional magnetic resonance imaging and DWI were performed on 85 patients with renal lesions (54 renal carcinoma and 31 renal angiomyolipoma cases). The apparent diffusion coefficient (ADC) values in each case at b=800 sec/mm 2 were measured in the ADC maps using a statistical software package. The 54 cases of renal cell carcinoma showed a high signal intensity in the parenchyma, and the 31 renal angiomyolipoma cases showed a well-defined mixed signal intensity on DWI. The soft-tissue component showed a high signal intensity and the fat tissue showed a low signal intensity on DWI. When the b-value was set to 800 sec/mm 2 , the mean ADC was significantly lower in the renal carcinoma cases than in the renal angiomyolipoma cases. In conclusion, the measurement of ADC on DWI can reveal the structure of renal tumors, which is beneficial in diagnosing and determining the prognosis of benign and malignant renal tumors.

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Section: Discussionsupporting

confidence: 93%

Diagnostic utility of diffusion-weighted magnetic resonance imaging in two common renal tumors

2015

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“…To date, analyses have been based on either a single ROI or a limited number of ROIs in each tumor [12–21, 24]. It is uncertain whether a single ROI drawn in a heterogeneous lesion can be considered representative of a whole tumor.…”

Section: Discussionmentioning

confidence: 99%

Use of DWI in the Differentiation of Renal Cortical Tumors

Hötker

Mazaheri

Wibmer

et al. 2016

American Journal of Roentgenology

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OBJECTIVE The purpose of this study was to differentiate clear cell renal cell carcinoma (RCC) from other common renal cortical tumors by use of DWI. MATERIALS AND METHODS The study included 117 patients (mean age, 60 years) with 122 histopathologically confirmed renal cortical tumors who underwent 1.5-T MRI that included DWI before they underwent nephrectomy between 2006 and 2013. For each tumor, two radiologists independently evaluated apparent diffusion coefficient (ADC) values on the basis of a single ROI in a nonnecrotic area of the tumor and also by assessment of the whole tumor. The concordance correlation coefficient (CCC) was calculated to assess interreader agreement. The mean ADC values of clear cell RCC and every other tumor subtype were compared using an exact Wilcoxon rank sum test. RESULTS Interreader agreement was excellent and higher in whole-tumor assessment (CCC, 0.982) than in single-ROI analysis (CCC, 0.756). For both readers, ADC values for clear cell RCC found on single-ROI assessment (2.19 and 2.08 × 10−3 mm2/s) and whole-tumor assessment (2.30 and 2.32 × 10−3 mm2/s) were statistically significantly higher than those for chromophobe, papillary, or unclassified RCC (p < 0.05) but were similar to those for oncocytoma found on single-ROI assessment (2.14 and 2.32 × 10−3 mm2/s) and whole-tumor assessment (2.38 and 2.24 × 10−3 mm2/s). ADC values were also higher for clear cell RCC than for angiomyolipoma, but the difference was statistically significant only in whole-tumor assessment (p < 0.03). CONCLUSION ADC values were statistically significantly higher for clear cell RCC than for chromophobe, papillary, or unclassified RCC subtypes; however, differentiating clear cell RCC from oncocytoma by use of DWI remains especially challenging, because similar ADC values have been shown for these two tumor types.

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“…In addition, we expect that CT diagnostic performance may be improved if multiple CT scanning phases are combined for TA in future. Some studies also tried to diagnose renal masses by special MR imaging techniques (diffusion-weighted imaging (25)(26)(27), arterial spin-labeling MR imaging (28), and MR spectroscopy (29)), but they are still in the stage of experimental research, and until now, no reliable diagnostic performance has been obtained.…”

Section: Discussionmentioning

confidence: 99%