EAACI position paper: skin prick testing in the diagnosis of occupational type I allergies

Kampen, V. van; Blay, F. De; Folletti, Ilenia; Kobierski, P.; Moscato, Gianna; Olivieri, Mario; Quirce, Santiago; Sastre, Joaquı́n; Walusiak‐Skorupa, Jolanta; Raulf‐Heimsoth, Monika

doi:10.1111/all.12120

Cited by 114 publications

(74 citation statements)

References 20 publications

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“…Después de transcurridos 15 minutos se hizo la interpretación de las pruebas, las cuales se consideraron positivas cuando al menos uno de los alérgenos provocó una pápula igual o mayor a 3 mm respecto al control negativo. 10 …”

Section: Abreviaturas Y Siglasunclassified

Prevalencia de insuficiencia y deficiencia de vitamina D en adultos mexicanos con asma alérgica

Bedolla-Barajas

López-Hernández

García-Padilla

et al. 2017

RAM

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Background: Hypovitaminosis D has been associated with various chronic diseases such as infections, autoimmune diseases, chronic obstructive pulmonary disease, cancer and asthma Objective: The objective at hand is to determine the prevalence of vitamin D (VD) insufficiency and deficiency in adults with allergic asthma. Methods: Through a cross-sectional study, we analyzed corresponding data amongst 135 patients. VD concentration was categorized as sufficient (≥ 30 ng/mL), insufficient (21-29 ng/mL), and deficient (≤ 20 ng/mL). The level of VD deficiency was measured through chemo-luminescence. We estimated the prevalence of VD alterations and their respective confidence intervals at 95 % (CI 95 %). Results: Within the analyzed population, there were 99/135 women (73.3 %); the mean age was 34.5 ± 10.3 years. The mean concentration of VD was 17.9 ± 6.9 ng/mL and the median was 17 ng/mL. The prevalence of VD insufficiency and deficiency was 25.2 % (CI 95 %, 18.6-33.2 %) and 71.1 % (CI 95 %, 62.9-78.1 %), respectively; VD concentrations ≤ 10 ng/mL had 13.3 % (CI 95 %, 8.5-20.2 %) and ≥ 30 ng/mL at 3.7 % (CI 95 %: 1.4-8.6 %). When we contrasted the men to the women, the median concentration of VD did not differ significantly (16 ng/mL vs. 18 ng/mL, p = 0.71). Conclusions: In this study, patients with allergic asthma had distinctively reduced VD concentration levels; future research will determine if and how VD affects the severity of asthma.

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Section: Abreviaturas Y Siglasunclassified

Prevalencia de insuficiencia y deficiencia de vitamina D en adultos mexicanos con asma alérgica

Bedolla-Barajas

López-Hernández

García-Padilla

et al. 2017

RAM

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“…Our study is the first to demonstrate differences between PPM-sensitized and nonsensitized patients using setae extracts. Standardization of SPT for occupational allergens, such as PPM, is highly recommended [19]. It is a cheap and effective way to determine the presence of specific IgE, and combined with a consistent clinical history enables a confident diagnosis of IgE-mediated allergic diseases [19].…”

Section: Discussionmentioning

confidence: 99%

“…Standardization of SPT for occupational allergens, such as PPM, is highly recommended [19]. It is a cheap and effective way to determine the presence of specific IgE, and combined with a consistent clinical history enables a confident diagnosis of IgE-mediated allergic diseases [19]. IgE immunoblotting is a less sensitive technique than SPT but it is very specific: 91% of patients with a positive SPT also had positive immunoblotting, demonstrating the usefulness of this test.…”

Section: Discussionmentioning

confidence: 99%

IgE Sensitization to <b><i>Thaumetopoea pityocampa</i></b>: Diagnostic Utility of a Setae Extract, Clinical Picture and Associated Risk Factors

Vega

Moneo²,

García-Ortiz

et al. 2014

Int Arch Allergy Immunol

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Background: Setae from Thaumetopoea pityocampa larvae (the pine processionary moth or PPM) can induce hypersensitivity reactions, but their clinical role in IgE-mediated responses is still subject to discussion. The aim of this study was to evaluate a setae extract for in vivo and in vitro diagnosis in nonhospitalized patients with reactions to PPM. Methods: Forty-eight adult patients presenting with PPM cutaneous reactions were studied by skin prick test (SPT) and specific IgE using setae and whole larval (WL) extracts. Biological standardized extracts were used for skin tests. Results: A total of 47.9% patients had a positive SPT for PPM (70% to both extracts, 17% only to the WL extract and 13% only to the setae extract). IgE immunoblotting detected several reactive bands in 91% of the SPT-positive cases. In multivariate analysis, male sex, immediate latency (<1 h) and duration of skin symptoms (<24 h) were independent predictors of a positive SPT. Conclusions: IgE sensitization to PPM was found in 48% of the study patients, which was associated with immediate reactions and evanescent cutaneous lesions. Most of these patients reacted to both WL and setae extracts, but some reacted to only one of them. According to our data, skin and in vitro tests to PPM should be performed using both extracts.

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“…Allergy skin prick tests have been the most common clinical test indicating the presence of specific IgE antibodies to high–molecular weight allergens, but there are limited available commercial extracts of occupational allergens, and some have low sensitivity (69). For high–molecular weight agents, if standardized extracts are not available, the actual material is potentially useful to test (using a slurry of a material or pricking a plant or food, then pricking the skin [a “prick-by-prick test]) (69).…”

Section: Methodsmentioning

confidence: 99%

An Official American Thoracic Society Workshop Report: Presentations and Discussion of the Sixth Jack Pepys Workshop on Asthma in the Workplace

Tarlo¹,

Malo²,

Blay³

et al. 2017

Annals ATS

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The Sixth Jack Pepys Workshop on Asthma in the Workplace focused on six key themes regarding the recognition and assessment of work-related asthma and airway diseases: (1) cleaning agents and disinfectants (including in swimming pools) as irritants and sensitizers: how to evaluate types of bronchial reactions and reduce risks; (2) population-based studies of occupational obstructive diseases: use of databanks, advantages and pitfalls, what strategies to deal with biases and confounding?; (3) damp environments, dilapidated buildings, recycling processes, and molds, an increasing problem: mechanisms, how to assess causality and diagnosis; (4) diagnosis of occupational asthma and rhinitis: how useful are recombinant allergens (component-resolved diagnosis), metabolomics, and other new tests?; (5) how does exposure to gas, dust, and fumes enhance sensitization and asthma?; and (6) how to determine probability of occupational causality in chronic obstructive pulmonary disease: epidemiological and clinical, confirmation, and compensation aspects. A summary of the presentations and discussion is provided in this proceedings document. Increased knowledge has been gained in each topic over the past few years, but there remain aspects of controversy and uncertainty requiring further research.

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EAACI position paper: skin prick testing in the diagnosis of occupational type I allergies

Cited by 114 publications

References 20 publications

Prevalencia de insuficiencia y deficiencia de vitamina D en adultos mexicanos con asma alérgica

Prevalencia de insuficiencia y deficiencia de vitamina D en adultos mexicanos con asma alérgica

IgE Sensitization to <b><i>Thaumetopoea pityocampa</i></b>: Diagnostic Utility of a Setae Extract, Clinical Picture and Associated Risk Factors

An Official American Thoracic Society Workshop Report: Presentations and Discussion of the Sixth Jack Pepys Workshop on Asthma in the Workplace

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