Abstract:Cerebral cortex development involves the sequential progression of biological steps driven by molecular pathways whose tight regulation often relies on ubiquitination.Ubiquitination is a posttranslational modification involved in all aspects of cellular homeostasis through the attachment of a ubiquitin (Ub) moiety on proteins. Over the past years, an increasing amount of research has highlighted the crucial role played by Ub ligases in every step of cortical development and whose impairment often leads to vari… Show more
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