2019
DOI: 10.1007/s00395-019-0737-y
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E2f1 deletion attenuates infarct-induced ventricular remodeling without affecting O-GlcNAcylation

Abstract: Several post-translational modifications figure prominently in ventricular remodeling. The beta-Olinkage of N-acetylglucosamine (O-GlcNAc) to proteins has emerged as an important signal in the cardiovascular system. Although there are limited insights about the regulation of the biosynthetic pathway that gives rise to the O-GlcNAc post-translational modification, much remains to be elucidated regarding the enzymes, such as O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), which regulate the presence/absence of… Show more

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Cited by 28 publications
(22 citation statements)
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“…The cDNA samples were diluted 10-fold with ddH 2 O. Real-time quantitative PCR was performed using 2 μl cDNA from each sample in a LightCycler 480 (Roche). The relative mRNA expression was calculated using the 2 −ΔΔCt method with 18S RNA as an internal control (Dassanayaka et al, 2019).…”
Section: Quantitative Real Time Pcrmentioning
confidence: 99%
“…The cDNA samples were diluted 10-fold with ddH 2 O. Real-time quantitative PCR was performed using 2 μl cDNA from each sample in a LightCycler 480 (Roche). The relative mRNA expression was calculated using the 2 −ΔΔCt method with 18S RNA as an internal control (Dassanayaka et al, 2019).…”
Section: Quantitative Real Time Pcrmentioning
confidence: 99%
“…RNA was extracted from cultured cells using the RNeasy mini kit (Qiagen, Germany). cDNA was synthesized using the iScript cDNA Synthesis Kit (Bio-Rad) [ 63 ]. Real-time PCR was performed with SYBR Green Master Mix (TOYOBO, Japan) and an ABI 7500 Fast Real-Time PCR System (Applied Biosystems, US).…”
Section: Methodsmentioning
confidence: 99%
“…The cardiac circulation is not only the culprit of acute myocardial infraction through coronary occlusion due to the formation of thrombus after plaque erosion or rupture but also a victim of reperfusion treatment after myocardial ischemia [9,10]. Structurally, endothelial cells constitute a layer between blood and extravascular cells and are responsible for maintaining the structure and regulating the function of blood vessels [11,12].…”
Section: Introductionmentioning
confidence: 99%