The generation of environmental-friendly energy is now one of the major demand of the world for healthy future. Fuel cell is one of the prime candidate in this regard which convert chemical energy of a fuel gas very efficiently and directly into electrical energy. This chapter describes the concept, impact of anode and electrolyte morphology, thickness, diameter, and fabrication of a micro-tubular solid oxide fuel cell (SOFC). The chapter describes the anode, cathode, and electrolyte of the cell components in more detail and their importance of each is regarding their size and thickness. Advantages of micro-tubular SOFCs with respect to the other fuel cell technologies are compared. The chapter describes the potential for directly running off hydrocarbon fuels and the design and operation of micro-tubular SOFCs on bio-fuel specifications and materials’ requirements. The chapter also discuss fabrication technology of micro-tubular single cell by using commercially available raw materials.