E-selectin-targeting lipid nanoparticles improve therapeutic efficacy and reduce side effects of bortezomib in multiple myeloma

Maksimos, Mina; Muz, Barbara; Magnani, John L.; Azab, Abdel Kareem

doi:10.1038/s41408-023-00828-4

Cited by 2 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The interaction mediated by E-selectin offers potential therapeutic avenues for addressing various diseases. Various exogenous inhibitors, such as carbohydrate molecules, carbohydrate mimics, small and large molecular mass non-carbohydrate compounds, peptides, antibodies targeting selectins, or nanoparticles, have been explored in this pursuit ( 88 – 91 ). Here we summarizes notable advancements and approaches in the development of pharmaceutical agents targeting E-selectin.…”

Section: Therapeutic Approaches Targeting E-selectinmentioning

confidence: 99%

E-selectin in vascular pathophysiology

Zhang,

Huang,

Zhu

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Selectins are a group of Ca2+-dependent, transmembrane type I glycoproteins which attract cell adhesion and migration. E-selectin is exclusively expressed in endothelial cells, and its expression is strongly enhanced upon activation by pro-inflammatory cytokines. The interaction of E-selectin with its ligands on circulating leukocytes captures and slows them down, further facilitating integrin activation, firm adhesion to endothelial cells and transmigration to tissues. Oxidative stress induces endothelial cell injury, leading to aberrant expression of E-selectin. In addition, the elevated level of E-selectin is positively related to high risk of inflammation. Dysregulation of E-selectin has been found in several pathological conditions including acute kidney injury (AKI), pulmonary diseases, hepatic pathology, Venous thromboembolism (VTE). Deletion of the E-selectin gene in mice somewhat ameliorates these complications. In this review, we describe the mechanisms regulating E-selectin expression, the interaction of E-selectin with its ligands, the E-selectin physiological and pathophysiological roles, and the therapeutical potential of targeting E-selectin.

show abstract

Section: Therapeutic Approaches Targeting E-selectinmentioning

confidence: 99%