E-selectin expression and BRAF status in papillary thyroid carcinomas: Correlation with clinicopathologic features

Miccoli, Paolo; Torregrossa, Liborio; Borrelli, Nicla; Materazzi, Gabriele; Insilla, Andrea Cacciato; Miccoli, Mario; Basolo, Fulvio

doi:10.1016/j.surg.2014.08.049

Cited by 2 publications

(2 citation statements)

References 24 publications

(37 reference statements)

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“…In particular, the ICAM1 and SELE genes encode for two adhesion molecules whose expression has been reported to be increased in PTC [51,52]. PTEN is one of the most important regulators of PI3K signaling, and its dysregulation has dramatic effects on this pathway.…”

Section: Discussionmentioning

confidence: 99%

Identification of Exosomal microRNAs and Their Targets in Papillary Thyroid Cancer Cells

et al. 2022

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The release of molecules in exosomal cargoes is involved in tumor development and progression. We compared the profiles of exosomal microRNAs released by two thyroid cancer cell lines (TPC-1 and K1) with that of non-tumorigenic thyroid cells (Nthy-ori-3-1), and we explored the network of miRNA–target interaction. After extraction and characterization of exosomes, expression levels of microRNAs were investigated using custom TaqMan Advanced array cards, and compared with those expressed in the total cell extracts. The functional enrichment and network-based analysis of the miRNAs’ targets was also performed. Five microRNAs (miR-21-5p, miR-31-5p, miR-221-3p, miR-222-3p, and let-7i-3p) were significantly deregulated in the exosomes of tumor cells vs. non-tumorigenic cells, and three of them (miR-31-5p, miR-222-3p, and let-7i-3p) in the more aggressive K1 compared to TPC-1 cells. The network analysis of the five miRNAs identified some genes as targets of more than one miRNAs. These findings permitted the identification of exosomal microRNAs secreted by aggressive PTC cells, and indicated that their main targets are regulators of the tumor microenvironment. A deeper analysis of the functional role of the targets of exosomal miRNAs will provide further information on novel targets of molecular treatments for these neoplasms.

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Section: Discussionmentioning

confidence: 99%

Identification of Exosomal microRNAs and Their Targets in Papillary Thyroid Cancer Cells

et al. 2022

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“…The altered expression of specific mRNAs such as fibronectin-1, TIMP1 and E-selectin (13,14) has been reported in thyroid tumors; however, to date no single mRNA has achieved satisfactorily high sensitivity and specificity to be effectively applied as potential marker on thyroid cytology. For this reason, several studies have recently investigated the potential role of mRNA panels rather than the analysis of expression of single genes.…”

Section: Molecular Tests Based On Mrna and Microrna (Mirna) Expressiomentioning

confidence: 99%

Current methodologies for molecular screening of thyroid nodules

Macerola

Basolo

2018

Gland Surg.

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Several molecular tests have been developed for thyroid cytology with the main purpose to define the nature of indeterminate nodules in presurgical phase thus overcoming the limitations of cytological analysis. Molecular tests currently available for thyroid nodules are based on a variety of methodologies and display peculiar strengths and limitations: in this review of the literature they are summarized and critically discussed. The use of molecular diagnostics for thyroid cytology is increasingly widespread and accepted, however large, prospective validation studies are still needed to ultimately demonstrate the clinical efficacy of a wide incorporation of molecular tests into clinical practice.

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E-selectin expression and BRAF status in papillary thyroid carcinomas: Correlation with clinicopathologic features

Cited by 2 publications

References 24 publications

Identification of Exosomal microRNAs and Their Targets in Papillary Thyroid Cancer Cells

Identification of Exosomal microRNAs and Their Targets in Papillary Thyroid Cancer Cells

Current methodologies for molecular screening of thyroid nodules

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