E‐selectin and L‐selectin polymorphisms in patients with periodontitis

Houshmand, B.; Rafiei, Alireza; Hajilooi, Mehrdad; Mani-Kashani, K.; Gholami, Leila

doi:10.1111/j.1600-0765.2008.01092.x

Cited by 17 publications

(10 citation statements)

References 26 publications

(34 reference statements)

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“…To date, eight studies evaluating the association of IL8 SNPs (−251, +396, and +781) and CP or AgP in different populations (mostly in Brazilian but none in the Caucasian population) have been performed, with contradictory results [ 27 – 32 , 34 , 35 ]. Most of these studies analyzed only the individual SNP and were focused on examining of CP; only Andia et al [ 32 ] studied the relationship between IL8 −251 variant and AgP; however, no association was found.…”

Section: Discussionmentioning

confidence: 99%

“…Very recently, Li et al [ 34 ] found that A allele of IL8 −251 variant was associated with decreased susceptibility to CP in Chinese population. Houshmand et al [ 35 ] found a significant difference in the genotype frequencies of IL8 −251A/T and +396G/T SNPs between subjects with periodontitis and a control group in Hamedan, Iran, but did not specify whether it was for patients with CP or AgP. Conversely, Corbi et al [ 31 ] showed that the genetic susceptibility to CP in the IL8 gene was not associated with worse periodontal clinical parameters and increased IL-8 concentration.…”

Section: Discussionmentioning

confidence: 99%

“…In the Chinese population, IL8 −251A allele has been associated with decreased susceptibility to CP [ 34 ]. The cross-sectional study in Iran has also focused on the study of polymorphisms in the IL8 gene but did not specify whether it was for patients with CP or AgP [ 35 ]. To date, no study analyzing allele, genotype, or haplotype frequencies of IL8 gene polymorphisms in patients with periodontitis has been performed in Caucasians.…”

Section: Introductionmentioning

confidence: 99%

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Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis

Linhartová

Vokurka

Poskerová

et al. 2013

Mediators of Inflammation

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Objectives. Periodontitis is an inflammatory disease characterized by connective tissue loss and alveolar bone destruction. Interleukin-8 (IL8) is important in the regulation of the immune response. The aim of this study was to analyze four polymorphisms in the IL8 gene in relation to chronic (CP) and aggressive (AgP) periodontitis. Methods. A total of 492 unrelated subjects were included in this case-control association study. Genomic DNA of 278 patients with CP, 58 patients with AgP, and 156 controls were genotyped, using the 5′ nuclease TaqMan assay, for IL8 (rs4073, rs2227307, rs2227306, and rs2227532) gene polymorphisms. Subgingival bacterial colonization was investigated by the DNA-microarray detection kit in a subgroup of subjects (N = 247). Results. Allele and genotype frequencies of all investigated IL8 polymorphisms were not significantly different between the subjects with CP and/or AgP and controls (P > 0.05). Nevertheless, the A(−251)/T(+396)/T(+781) and T(−251)/G(+396)/C(+781) haplotypes were significantly less frequent in patients with CP (2.0% versus 5.1%, P < 0.02, OR = 0.34, 95% CI: 0.15–0.78, resp., 2.0% versus 4.5%, P < 0.05, OR = 0.41, 95% CI: 0.18–0.97) than in controls. Conclusions. Although none of the investigated SNPs in the IL8 gene was individually associated with periodontitis, some haplotypes can be protective against CP in the Czech population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis

Linhartová

Vokurka

Poskerová

et al. 2013

Mediators of Inflammation

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“…In the study, we had investigated for the potential of a microemulsion based in situ electrolyte-triggered gelling systems for specific delivery of Ciprofloxacin to posterior ocular tissue and fluids. Compared to two other formulations, those are in situ gelling system and eye drop solutions, the Ciprofloxacin microemulsion based in situ gelling system showed better penetration into ocular tissues, higher Ciprofloxacin levels in the vitreous humor, and prolonged residence in the cornea 32 .…”

Section: Discussionmentioning

confidence: 87%

In-vivo Evaluation and Characterization of Novel In-Situ Gelling System as Controlled Delivery System Containing Ciprofloxacin for Ocular Drug Delivery

Fatima¹,

Vivek

2020

J. Drug Delivery Ther.

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Objectives: The purpose of this research was to develop the micro emulsion-based in situ gelling systems containing Ciprofloxacin for prophylaxis and treatment of the posterior segment diseases like endophthalmitis. Methods: Ciprofloxacin was encapsulated in small droplets owing to form microemulsion, and then the formed droplets were dispersed in a polymer solution that converted into a gel upon triggered by the electrolyte present in the tear fluid. Results: The formulation approach provides better absorption, penetration, retention, and improves the bioavailability of the drug. The average concentration reached into vitreous humor from topical microemulsion in situ gelling formulation was ~0.4 µg/ml, which is far more than the concentration required for therapeutic effect (i.e. >0.047 µg/ml or >MIC90 for S. Epidermidis, a pathogen commonly responsible to cause endophthalmitis). Conclusion: Thus, novel micro emulsion-based in situ gelling formulation could be a potential drug delivery system for the treatment of posterior segment diseases like endophthalmitis. Keywords: Microemulsion, ciprofloxacin, endophthalmitis, ocular, infection, in situ

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“…CXCR1 and CXCR2 genes and their polymorphisms were reported by four studies 18,24,36,39 . Twenty-two studies focused on IL-8 polymorphisms and their different variants findings 12,[17][18][19][20][21][22][23][25][26][27][28][30][31][32][33]37,40,41,[43][44][45] .…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Periodontitis association with IL-8 gene polymorphisms

Kriaučiūnas

Žekonis

Liutkevičienė

2022

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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IL-8 and its polymorphisms are involved in multiple acute and chronic inflammatory processes including pathological changes to surrounding structures of the teeth called periodontal diseases or periodontitis. The aim of this manuscript was to systematically review studies from 2006 to 2021 on IL-8 polymorphisms and their association with periodontitis. Literature analysis was done following the PRISMA protocol guidance using articles not older than 15 years (2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018)(2019)(2020)(2021). The search was carried out using PubMed (MEDLINE), ScienceDirect and Wiley Online Library databases. For the focus question, the PICO (population (P), intervention (I), control (C), and outcome (O)) study design protocol was used, and the following question was formulated: are IL-8 gene polymorphisms associated with periodontitis? A total of 2422 articles were found at the beginning of the search. After applying the inclusion and exclusion criteria, screening, and full-text article exclusion with reasons, 31 studies were included in the analysis. In conclusion, IL-8 and its gene polymorphisms are associated with an increased risk of periodontal diseases.

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E‐selectin and L‐selectin polymorphisms in patients with periodontitis

Abstract: The findings of this study showed that the Ser128Arg polymorphism of E-selectin might contribute to the susceptibility of Iranian individuals to periodontitis.

Cited by 17 publications

References 26 publications

Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis

Haplotype Analysis of Interleukin-8 Gene Polymorphisms in Chronic and Aggressive Periodontitis

In-vivo Evaluation and Characterization of Novel In-Situ Gelling System as Controlled Delivery System Containing Ciprofloxacin for Ocular Drug Delivery

Periodontitis association with IL-8 gene polymorphisms

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