E.P.R. spectroscopy of the radicals formed in a single crystal of 6-azathymine by irradiation

Herak, Janko N.; Schoffa, G.

doi:10.1080/00268977100102671

Cited by 17 publications

(3 citation statements)

References 14 publications

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“…In recent results on irradiated single crystals of 6azathymine Herak and Schoffa suggest a radical analogous to radical VIII is formed by hydrogen atom abstraction. 18 Results found here would suggest the deprotonation of the positive ion as an alternative explanation.…”

Section: Discussionmentioning

confidence: 57%

Reactions of the cation and anion radicals of several DNA bases

Sevilla¹,

Paemel²,

Zorman³

1972

J. Phys. Chem.

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Section: Discussionmentioning

confidence: 57%

Reactions of the cation and anion radicals of several DNA bases

Sevilla¹,

Paemel²,

Zorman³

1972

J. Phys. Chem.

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“…A small fraction of the OH radicals were found to abstract H atoms from the methyl groups attached at the N(1), N(3), C(5) and C(6) positions . Such radicals have been observed in single crystals of 5-methylcytosine (Huttermann, Ward and Myers 1971), 6-azathymine (Herak and Schoffa 1971), 1-methyluracil (Flossman, Huttermann, Muller and Westhof 1973) and 1-methylthymine (Schmidt 1975) . In aqueous solutions, the radical formed by H-abstraction from the methyl group of thymine has been observed only at pH > 12 (Nicolau et al 1969, Neta 1972 .…”

Section: Discussionmentioning

confidence: 94%

“…In single crystals of 6-azathymine, y-or X-irradiated at room temperature, only abstraction from the methyl group takes place (Herak and Schoffa 1971) . The spin-trapped radical from 6-azathymine shows a 16 .…”

Section: Thymine and Its Derivativesmentioning

confidence: 99%

E.S.R. of Free Radicals in Aqueous Solutions of Substituted Pyrimidines

Rustgi

Riesz

1978

International Journal of Radiation Biology and Related Studies

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Reactions of OH radicals with methyl and ethyl derivatives of uracil, cytosine and thymine in aqueous solutions have been investigated. Photolysis of H2O2 was used to generate OH radicals and the radicals on the base derivatives were spin-trapped using t-nitrosobutane and identified with the help of e.s.r. spectroscopy. Addition of OH radicals was found to take place predominantly to the C(5)--C(6) double bond of the bases. H-abstraction from the methyl group occurred in the N(1) methyl derivatives of uracil, cytosine and thymine. Radicals formed by H-abstraction from the methyl group were also detected for 3-methyluracil, thymine, 1-methylthymine and 1-ethylthymine. Introduction of a methyl or ethyl group at the N(1) position of uracil, cytosine and thymine causes an increase in the C(6) proton coupling and a decrease in the N(1) splitting for radicals formed by OH addition at the C(5) position.

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Polymers Containing the 1,2,4‐Triazine Nucleus

1978

Chemistry of Heterocyclic Compounds: A Series of Monographs

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E.P.R. spectroscopy of the radicals formed in a single crystal of 6-azathymine by irradiation

Cited by 17 publications

References 14 publications

Reactions of the cation and anion radicals of several DNA bases

Reactions of the cation and anion radicals of several DNA bases

E.S.R. of Free Radicals in Aqueous Solutions of Substituted Pyrimidines

Polymers Containing the 1,2,4‐Triazine Nucleus

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