E.E.G. Monitoring for the Control of Anaesthesia Produced by the Infusion of Althesin in Primates

Prior, Pamela F.; Maynard, D.E.; Brierley, J. B.

doi:10.1093/bja/50.10.993

Cited by 43 publications

(15 citation statements)

References 14 publications

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“…However, it was concluded that the alfaxalone–alfadolone combination decreased the dominating EEG frequencies, caused increasing degrees of burst suppression and even complete electrical silence at higher doses (Fitch et al. 1978; Prior et al. 1978; Saady & Hicks 1980; Ogawa 1987).…”

Section: Discussionmentioning

confidence: 99%

“…There are publications about the effects of the alfaxalone–alfadolone combinations on the EEG of humans, primates and cats (Fitch et al. 1978; Prior et al. 1978; Saady & Hicks 1980; Ogawa 1987) but not of dogs.…”

Section: Introductionmentioning

confidence: 99%

“…There are publications about the effects of the alfaxalone-alfadolone combinations on the EEG of humans, primates and cats (Fitch et al 1978;Prior et al 1978;Saady & Hicks 1980;Ogawa 1987) but not of dogs. Additionally, these old studies did not report the results of power spectral analysis such as median (F 50 ) and 95% spectral edge frequency (F 95 ) and total EEG power (P tot ).…”

Section: Introductionmentioning

confidence: 99%

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Effect of alfaxalone infusion on the electroencephalogram of dogs anaesthetized with halothane

Ambriskó

Johnson

Chambers

2011

Veterinary Anaesthesia and Analgesia

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of alfaxalone infusion on the electroencephalogram of dogs anaesthetized with halothane

Ambriskó

Johnson

Chambers

2011

Veterinary Anaesthesia and Analgesia

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“…3) according to the global stage analysis chart of Prior, et al 9 and they remained constant over an arterial pressure range of 120-40 mm Hg. The scatter of the individual recordings is shown in figure 4.…”

Section: Electroencephalogrammentioning

confidence: 95%

Effects of hemorrhagic hypotension on the cerebral circulation. II. Electrocortical function.

Gregory¹,

McGeorge²,

Fitch³

et al. 1979

Stroke

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SEVERE HYPOTENSION produces a loss of cerebral function, the extent and reversibility of which depends on the degree and duration of the period of hypotension. Recent studies have described the changes in cerebral function over periods of sustained hypotensionThe present study forms part of a systemic investigation which attempts to correlate the changes in cerebral blood flow during graded hemorrhagic hypotension with the subsequent alteration in cerebral functional activity and the development of hypoxic brain damage.This communication reports the changes observed in cerebral functional activity during hypotension and relates these changes to the arterial pressure and to the corresponding alterations in the cerebral circulation. The detailed accounts of the impairment of the cerebral circulation and development of brain damage due to hypotension are given in the accompanying papers. 5 ' 6 It has been suggested 7 that the somatosensory evoked response is a more accurate guide than the EEG to brain damage during hypotension. Therefore, both these parameters were measured in this study. Methods General DescriptionThe effect of graded hemorrhagic hypotension on electrocortical activity was determined in 2 parallel studies in a total of 12 cats, of either sex, weighing between 1.6 and 4.8 kg. Anesthesia and general Reprints: Dr. David I. Graham, the University of Glasgow, Wellcome Surgical Institute, Garscube Estate, Bearsden Road, Bearsden, Glasgow, G61 1QH, Scotland. preparation of the animals were identical to those described previously. Measurement of Somatosensory Evoked ResponseSix cats were used to study the effects of hypotension on the somatosensory evoked response. The cats were placed in a head-holder and the scalp was incised along the midline and reflected. A small craniotomy (approximately 1.5 X 1.0 cm) was made over the sensory cortex, using a saline-cooled dental drill, and a reference silver-electrode was implanted in the neck muscle. A supramaximal stimulus (0.5-2V, 0.2 msec, 1 Hz) was applied via a DISA type 14 E12 time base unit to the contralateral superficial radial nerve. Bipolar silver ball-tipped recording electrodes were then positioned (1 cm apart) on the surface of the dura to obtain maximal potential. Signals from the recording electrodes were amplified with a band width of 2-500 Hz and the average of 16 evoked potentials recorded with a DISA type 14 GO1 digital averager from which the measurements were taken and of which a photographic record was kept.The somatosensory evoked response was recorded for a control period of 30 min and then the animal was subjected to stepwise hypotension induced by controlled hemorrhage.5 Mean arterial pressure was decreased by approximately 10 mm Hg at each step and allowed to stabilize for approximately 10 min at each new level before the potentials were recorded. The effect of this hypotension on the evoked response was assessed in terms of the average peak-to-peak amplitude of the positive/negative sequence of the primary evoked response; 8 and t...

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“…These strips were later analyzed using a 5-point visual inspection scale modified from a scale described by Prior et al (1978). Details of the grading scale have been described elsewhere (DeWitt et al, 1992a;1992b).…”

Section: Animal Preparationmentioning

confidence: 99%

Effects of Nalmefene, CG3703, Tirilazad, or Dopamine on Cerebral Blood Flow, Oxygen Delivery, and Electroencephalographic Activity After Traumatic Brain Injury and Hemorrhage

DeWitt¹,

Prough²,

Uchida³

et al. 1997

Journal of Neurotrauma

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Hemorrhage after traumatic brain injury (TBI) in cats produces significant decreases in cerebral oxygen delivery (DcereO2) and electroencephalographic (EEG) activity. To determine whether effective treatments for the separate insults of TBI and hemorrhagic shock would also prove effective after the clinically relevant combination of the two, we measured the effects of a kappa-opiate antagonist (nalmefene), an inhibitor of lipid peroxidation (tirilazad), a thyrotropin-releasing hormone analog (CG3703), a clinically useful pressor agent (dopamine) or a saline placebo on cerebral blood flow (CBF), and EEG activity after TBI and mild hemorrhagic hypotension. Cats (n = 40, 8 per group) were anesthetized with 1.6% isoflurane in N2O:O2 (70:30) and prepared for fluid-percussion TBI and microsphere measurements of CBF. Cats were randomized to receive nalmefene (1 mg/kg), tirilazad (5 mg/kg), CG3703 (2 mg/kg), dopamine (20 microg x kg(-1) x min[-1]) or a saline placebo (2 ml, 0.9% NaCl). Animals were injured (2.2 atm), hemorrhaged to 70% of preinjury blood volume, treated as just described and resuscitated with a volume of 10% hydroxyethyl starch equal to shed blood. CBF was determined and EEG activity recorded before injury, after hemorrhage, and 0, 60, and 120 min after resuscitation (R0, R60, and R120). CBF increased significantly after resuscitation (R0) in the nalmefene- and CG3703-treated groups. CBF did not differ significantly from baseline in any group at R60 or R120. DcereO2 was significantly less than baseline in the saline-, dopamine-, and tirilazad-treated groups at R60 and in the dopamine-, tirilazad-, and CG3703-treated groups at R120. EEG activity remained unchanged in the nalmefene-treated group but deteriorated significantly at R60 or R120 compared to baseline in the other groups. Nalmefene and CG3703 preserved the hyperemic response to hemodilution (otherwise antagonized by TBI), and nalmefene prevented the deterioration in DcereO2 and EEG activity that occurs after TBI and hemorrhage.

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E.E.G. Monitoring for the Control of Anaesthesia Produced by the Infusion of Althesin in Primates

Cited by 43 publications

References 14 publications

Effect of alfaxalone infusion on the electroencephalogram of dogs anaesthetized with halothane

Effect of alfaxalone infusion on the electroencephalogram of dogs anaesthetized with halothane

Effects of hemorrhagic hypotension on the cerebral circulation. II. Electrocortical function.

Effects of Nalmefene, CG3703, Tirilazad, or Dopamine on Cerebral Blood Flow, Oxygen Delivery, and Electroencephalographic Activity After Traumatic Brain Injury and Hemorrhage

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