“…Vibrio cholerae produces a toxin (the zonula occludens toxin), which causes disintegration of tight junctions by acting on the zonula occludens protein, which increases the permeability of the intestinal barrier (Fasano et al, 1991). Currently, yet another factor is being discussed that may affect the development and maturation of the intestinal mucosa, since Galeano et al (2014) have shown that bacterial lipopolysaccharide (LPS) induces in the intestines of young piglets functional disorders that cause reduced expression of the proteins that form the intestinal barrier. They observed reduced expression of Claudine 3 and 4 and zonula occludens-1 proteins in piglets fed a diet containing LPS.…”