E-Cigarette Aerosols and the Brain: Behavioral and Neuroinflammatory Changes in Prenatally Exposed Adult Mice

Schmidt, Silke

doi:10.1289/ehp7315

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…Although the data on e-cig vaping and developing brain has been limited, the fetal brain has been demonstrated as a major target of prenatal e-cig exposure. E-cig exposure has been reported to disrupt mouse blood brain barrier and induce proinflammatory cytokines ( Schmidt, 2020 ) in postnatal brain and induces long-term neurovascular changes and worsening behavioral outcomes ( Sabrina Rahman Archie et al, 2023 ). E-cig exposure downregulates autophagy-related gene expression via DNA hypermethylation in neonatal brain in rat model ( Walayat et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of e-cigarette vaping aerosol exposure in pregnancy on mTOR signaling in rat fetal hippocampus

et al. 2023

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Electronic cigarette (e-cig) use during pregnancy has become a major health concern in recent years and many view them as less harmful and may help quit or reduce combustible cigarettes. Implementing a state-of-the-art engineered vaping system, comprising an atomizer similar to those sold in vape shops, we aimed to utilize a translational e-cig inhalation delivery method to provide crucial information on the impact of prenatal e-cig aerosols on the developing brain hippocampal mTOR system in a rat model system. Gestational e-cig vaping significantly increased P-mTOR levels (p < 0.05) in the rat fetal hippocampi in the nicotine group (comprising of VG/PG + nicotine) compared to the control and the juice (comprising of VG/PG) groups. Total mTOR expression was not different among groups. Immunofluorescence imaging demonstrated P-mTOR was detected exclusively in the granule cells of the dentate gyrus of the fetal hippocampus. E-cig did not alter DEPTOR, but RAPTOR and RICTOR were higher (p < 0.05) in the Nicotine group. Gestational e-cig vaping with nicotine increased (p < 0.05) the activity and expression of 4EBP1, p70S6K, but decreased (p < 0.05) P-PKCα in the fetal hippocampi. In summary, dysregulation of mTORC1 and the related mTORC2, their activity, and downstream proteins together may play a critical role in e-cig-vaping-induced neurobiological phenotypes during development.

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Section: Introductionmentioning

confidence: 99%

Impact of e-cigarette vaping aerosol exposure in pregnancy on mTOR signaling in rat fetal hippocampus

et al. 2023

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Single-nucleus chromatin accessibility and RNA sequencing reveal impaired brain development in prenatally e-cigarette exposed neonatal rats

Chen

et al. 2022

iScience

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In utero exposures to mint-flavored JUUL aerosol impair lung development and aggravate house dust mite-induced asthma in adult offspring mice

Cahill

Johnson²,

Perveen³

et al. 2022

Toxicology

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E-Cigarette Aerosols and the Brain: Behavioral and Neuroinflammatory Changes in Prenatally Exposed Adult Mice

Abstract: Vaping does not expose users to all the toxicants produced by tobacco combustion. However, it presents its own unique exposures-such as the solvents in e-liquid-and potential health risks.

Cited by 4 publications

References 18 publications

Impact of e-cigarette vaping aerosol exposure in pregnancy on mTOR signaling in rat fetal hippocampus

Impact of e-cigarette vaping aerosol exposure in pregnancy on mTOR signaling in rat fetal hippocampus

Single-nucleus chromatin accessibility and RNA sequencing reveal impaired brain development in prenatally e-cigarette exposed neonatal rats

In utero exposures to mint-flavored JUUL aerosol impair lung development and aggravate house dust mite-induced asthma in adult offspring mice

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