E-Cigarette Aerosol Deposition and Disposition of [11C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations

Wall, Anders; Roslin, Sara; Borg, Béatrice; McDermott, Simon; Walele, Tanvir; Nahde, Thomas; O’Connell, Grant; Thompson, Joseph; Lubberink, Mark; Antoni, Gunnar

doi:10.3390/ph15030367

Cited by 14 publications

(13 citation statements)

References 27 publications

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“…176 Recently, Wall et al studied the distribution and accumulation of inhaled [ 11 C]nicotine in the respiratory pathways and brain of 15 healthy adult smokers using the myblu e-cigarette with two nicotine formulations, freebase, and lactate salt. 133 Over 30% of the inhaled tracer accumulated in the lung within 15−35 seconds. [ 11 C]Nicotine freebase exhibited higher uptake and deposition in the upper respiratory pathways than [ 11 C]nicotine lactate .…”

Section: Clinical Studiesmentioning

confidence: 99%

“…For [ 11 C]nicotine lactate , brain deposition peaked at 4–5%, with an earlier peak and a steeper decline (Figure ). The authors concluded that e-cigarettes with nicotine lactate formulations might contribute to greater adult smoker acceptance and satisfaction …”

Section: Alkaloidsmentioning

confidence: 99%

“…[ 11 C]Nicotine freebase (top) and [ 11 C]nicotine lactate (bottom) distribution in human lungs and mouth (0.5, 5, and 40 min after inhalation). Reproduced with permission from ref . Copyright 2022 MDPI.…”

Section: Alkaloidsmentioning

confidence: 99%

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Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

et al. 2022

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The presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensitivity and the introduction of total body PET systems, has increased the interest in the PET tracer development using the short-lived radionuclides carbon-11. In the last few decades, methodological improvements and fully automated modules have allowed the development of carbon-11 tracers for clinical use. Radiolabeling natural compounds with carbon-11 by substituting one of the backbone carbons with the radionuclide has provided important information on the biochemistry of the authentic compounds and increased the understanding of their in vivo behavior in healthy and diseased states. The number of endogenous and natural compounds essential for human life is staggering, ranging from simple alcohols to vitamins and peptides. This review collates all the carbon-11 radiolabeled endogenous and natural exogenous compounds synthesised to date, including essential information on their radiochemistry methodologies and preclinical and clinical studies in healthy subjects.

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Section: Clinical Studiesmentioning

confidence: 99%

Section: Alkaloidsmentioning

confidence: 99%

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Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

et al. 2022

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“…3 Previous studies have reported methods for measuring the deposition and uptake amount of the constituents in tobacco product aerosols. 4 used positron emission tomography imaging methods to visualize and analyze inhaled isotope-labeled nicotine, and Ishikawa et al 5 estimated the inhaled amounts of aerosols by analyzing the exhaled aerosols. These methods can be used for broad measures of the amount of aerosol deposition and uptake, such as total, organ-specific, or lung lobe-specific dosimetry; however, other approaches are necessary for analyzing local concentrations of aerosols.…”

mentioning

confidence: 99%

A revision of the multiple‐path particle dosimetry model focusing on tobacco product aerosol dynamics

Mori,

Ito,

Sekine

2024

Numer Methods Biomed Eng

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To assess the health impact of inhaled aerosols, it is necessary to understand aerosol dynamics and the associated dosimetry in the human respiratory tract. Although several studies have measured or simulated the dosimetry of aerosol constituents, the respiratory tract focus areas have been limited. In particular, the aerosols generated from tobacco products are complex composites and simulating their dynamics in the respiratory tract is challenging. To assess the dosimetry of the aerosol constituents of tobacco products, we developed a revised version of the Multiple‐Path Particle Dosimetry (MPPD) model, which employs (1) new geometry based on CT‐scanned human respiratory tract data, (2) convective mixing in the oral cavity and deep lung, and (3) constituent partitioning between the tissue and air, and clearance. The sensitivity analysis was conducted using aerosols composed of four major constituents of electronic cigarette (EC) aerosols to investigate the parameters that have a significant impact on the results. In addition, the revised model was run with 4 and 10 constituents in ECs and conventional cigarettes (CCs), respectively. Sensitivity analysis revealed that the new modeling and the physicochemical properties of constituents had a considerable impact on the simulated aerosol concentration and dosimetry. The simulations could be carried out within 3 min even when 10 constituents of CC aerosols were analyzed simultaneously. The revised model based on MPPD is an efficient and easy‐to‐use tool for understanding the aerosol dynamics of CC and EC constituents and their effect on the human body.

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“…The rate and effectiveness of inhaled drug accumulated in the lungs, blood, and brain are well documented in tracking of radiolabeled nicotine by positron-emission tomography following a few puffs of conventional or e-cigarette smoke (3,4). Under typical smoking conditions, brain 11 C-nicotine accumulation was found to begin approximately 7-15 s after the radioactivity was detected in the oral cavity (3).…”

mentioning

confidence: 99%

Atezolizumab Retains Cellular Binding to Programmed Death Ligand 1 Following AerosolizationviaMesh Nebulizer

ZALESKIS¹,

TALAIKIS²,

Characiejus³

et al. 2023

Anticancer Res

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Background/Aim: Cytotoxic inhalable drugs were shown to be advantageous in treating malignancies of the respiratory tract. However, these drugs have not always presented a safe profile and were reported to induce local adverse events. Protein-based anticancer drugs, such as immune checkpoint and vascular endothelial growth factor inhibitors, do not induce tissue injury, nor do they exhibit vesicant properties upon direct contact with tissues. Protein drugs are susceptible to the heat and stress encountered during droplet generation for delivery by nebulization. The aim of this study was to investigate the capacity of atezolizumab, an antibody to programmed death ligand 1, to bind target cells after nebulization with a vibrating mesh (VM) nebulizer. Materials and Methods: We compared Fourier-transformed infrared (FTIR) and Raman spectra of native atezolizumab (60 mg/ml) and its nebulized form following 10-min nebulization in a piezoceramic VM nebulizer. The binding of atezolizumab to DU-145 prostate cancer cells was evaluated using competitive blocking of anti-CD274 staining. Results: Nebulization did not induce Raman or FTIR spectral modification nor did it affect the binding capacity of atezolizumab. Conversely, heat-inactivated atezolizumab lost its cell-binding capacity and did not reduce anti-CD274

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E-Cigarette Aerosol Deposition and Disposition of [11C]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations

Cited by 14 publications

References 27 publications

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

A revision of the multiple‐path particle dosimetry model focusing on tobacco product aerosol dynamics

Atezolizumab Retains Cellular Binding to Programmed Death Ligand 1 Following AerosolizationviaMesh Nebulizer

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