(+)-(E)-Chrysanthenyl Acetate: A Molecule with Interesting Biological Properties Contained in the Anthemis secundiramea (Asteraceae) Flowers

Maresca, Viviana; Varcamonti, Mario; Bruno, Maurizio; Badalamenti, Natale; Basile, Adriana

doi:10.3390/app10196808

Cited by 22 publications

(15 citation statements)

References 63 publications

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“…Cells were cultured at 37 °C in humidified atmosphere of 5% CO 2 . The compounds 1P, 2P, 3P, 1MC, 2MC, 3MC, 1BC, 2BC, Ag 2 O e AgNO 3 were used for the cytotoxicity assay [ 33 ].…”

Section: Methodsmentioning

confidence: 99%

Silver (I) N-Heterocyclic Carbene Complexes: A Winning and Broad Spectrum of Antimicrobial Properties

Prencipe

Zanfardino

Napoli

et al. 2021

IJMS

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The evolution of antibacterial resistance has arisen as the main downside in fighting bacterial infections pushing researchers to develop novel, more potent and multimodal alternative drugs.Silver and its complexes have long been used as antimicrobial agents in medicine due to the lack of silver resistance and the effectiveness at low concentration as well as to their low toxicities compared to the most commonly used antibiotics. N-Heterocyclic Carbenes (NHCs) have been extensively employed to coordinate transition metals mainly for catalytic chemistry. However, more recently, NHC ligands have been applied as carrier molecules for metals in anticancer applications. In the present study we selected from literature two NHC-carbene based on acridinescaffoldand detailed nonclassicalpyrazole derived mono NHC-Ag neutral and bis NHC-Ag cationic complexes. Their inhibitor effect on bacterial strains Gram-negative and positivewas evaluated. Imidazolium NHC silver complex containing the acridine chromophore showed effectiveness at extremely low MIC values. Although pyrazole NHC silver complexes are less active than the acridine NHC-silver, they represent the first example of this class of compounds with antimicrobial properties. Moreover all complexesare not toxic and they show not significant activity againstmammalian cells (Hek lines) after 4 and 24 h. Based on our experimental evidence, we are confident that this promising class of complexes could represent a valuable starting point for developing candidates for the treatment of bacterial infections, delivering great effectiveness and avoiding the development of resistance mechanisms.

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“…Cells were cultured at 37 °C in humidified atmosphere of 5% CO 2 . The compounds 1P, 2P, 3P, 1MC, 2MC, 3MC, 1BC, 2BC, Ag 2 O e AgNO 3 were used for the cytotoxicity assay [ 33 ].…”

Section: Methodsmentioning

confidence: 99%

Silver (I) N-Heterocyclic Carbene Complexes: A Winning and Broad Spectrum of Antimicrobial Properties

Prencipe

Zanfardino

Napoli

et al. 2021

IJMS

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“…To counter this effect, secondary metabolites [123][124][125], produced by plant species as defence mechanisms, could represent a resource to be exploited for obtaining new drugs. Additionally, synthetic compounds [126][127][128] can be used to counteract the attack of parasites and pathogens before they can cause serious structural damage.…”

Section: Antibacterial and Antifungal Activitymentioning

confidence: 99%

Ethnobotany, Phytochemistry, Biological, and Nutritional Properties of Genus Crepis—A Review

Badalamenti

Sottile

Bruno

2022

Plants

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The genus Crepis L., included within the Asteraceae family, has a very wide distribution, expanding throughout the northern hemisphere, including Europe, northern Africa, and temperate Asia. This genus has a fundamental value from biodynamic and ecological perspectives, with the different species often being chosen for soil conservation, for environmental sustainability, and for their attraction towards pollinating species. Furthermore, various species of Crepis have been used in the popular medicine of several countries as medicinal herbs and food since ancient times. In most cases, the species is consumed either in the form of a decoction, or as a salad, and is used for its cardiovascular properties, as a digestive, for problems related to sight, for the treatment of diabetes, and for joint diseases. This literature review, the first one of the Crepis genus, includes publications with the word ‘Crepis’, and considers the single metabolites identified, characterised, and tested to evaluate their biological potential. The various isolated compounds, including in most cases sesquiterpenes and flavonoids, were obtained by extracting the roots and aerial parts of the different species. The secondary metabolites, extracted using traditional (solvent extraction, column chromatography, preparative thin layer chromatography, preparative HPLC, vacuum liquid chromatography), and modern systems such as ultrasounds, microwaves, etc., and characterised by mono- and bi- dimensional NMR experiments and by HPLC-MS, have a varied application spectrum at a biological level, with antimicrobial, antioxidant, antidiabetic, antitumor, antiviral, antiulcer, phytotoxic, and nutritional properties having been reported. Unfortunately, in vitro tests have not always been accompanied by in vivo tests, and this is the major critical aspect that emerges from the study of the scientific aspects related to this genus. Therefore, extensive investigations are necessary to evaluate the real capacity of the different species used in food, and above all to discover what the different plants that have never been analysed could offer at a scientific level.

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“…Thus, the main purpose of this study was to undertake the first study of the application of the Thymus essential oil to heritage leather disinfection under a vacuum system. Consequently, in the context of our ongoing research on endemic Sicilian plants [ 27 , 28 , 29 ] and the biological activity of essential oils [ 30 , 31 , 32 ], and in consideration of the important antibacterial properties of the essential oil Thymus demonstrated in the aforementioned articles, we decided to utilize the EO of Thymus vulgaris as natural biocide against bacteria affecting two Tholu Bommalu , typical Indian leather puppets, which were stored at the International Puppets Museum “Antonio Pasqualino”. We exploited the high vacuum inside ad hoc chambers in order to speed up the disinfection process.…”

Section: Introductionmentioning

confidence: 99%

The Application of the Essential Oils of Thymus vulgaris L. and Crithmum maritimum L. as Biocidal on Two Tholu Bommalu Indian Leather Puppets

D’Agostino

Giambra

Palla

et al. 2021

Plants

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The chemical profile of the Thymus vulgaris (Lamiaceae) essential oil (EO) was investigated in order to evaluate its biological properties against microorganisms affecting two Tholu Bommalu, typical Indian leather puppets stored at the International Puppets Museum “Antonio Pasqualino” of Palermo, Italy. A GC–MS analysis, using both polar and apolar columns, was used to determine the chemical composition of the essential oil. The aim of this study was to evaluate the antimicrobial effectiveness of the Thymus vulgaris and Crithmum maritimum essential oils in vapor phase to disinfect heritage leather puppets. Pieces of leather artifacts that were affected by different bacterial colonies were exposed to EO under vacuum and static evaporation conditions. The results presented showed that the vaporization of essential oil was an efficient method in the disinfection of natural skins, eradicating microorganism in short times. T. vulgaris EO in the 50% solution showed excellent inhibitory activity against isolated bacteria with both methods, but the obtained results suggest that the vacuum method allowed for faster exposition of the artifacts to the biocide. Furthermore, the biocidal properties of the essential oil of a Sicilian accession of Crithmum maritimum (Apiaceae) aerial parts were compared and investigated. The results of the latter essential oil showed a poor activity against the isolated micro-organisms.

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(+)-(E)-Chrysanthenyl Acetate: A Molecule with Interesting Biological Properties Contained in the Anthemis secundiramea (Asteraceae) Flowers

Cited by 22 publications

References 63 publications

Silver (I) N-Heterocyclic Carbene Complexes: A Winning and Broad Spectrum of Antimicrobial Properties

Silver (I) N-Heterocyclic Carbene Complexes: A Winning and Broad Spectrum of Antimicrobial Properties

Ethnobotany, Phytochemistry, Biological, and Nutritional Properties of Genus Crepis—A Review

The Application of the Essential Oils of Thymus vulgaris L. and Crithmum maritimum L. as Biocidal on Two Tholu Bommalu Indian Leather Puppets

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