E-cadherin expression is more associated with histopathological type of thyroid cancer than with the metastatic potential of tumors

Słowińska-Klencka, Dorota; Sporny, Stanisław; Stasikowska-Kanicka, Olga; Popowicz, Bożena; Klencki, Mariusz

doi:10.5603/fhc.2012.0073

Cited by 4 publications

(4 citation statements)

References 26 publications

(18 reference statements)

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“…Low E-cadherin expression is further linked to more aggressive epithelial cancer cell invasiveness and poor prognosis [39,40]. Regarding thyroid cancer, E-cadherin expression is reversely associated with aggressiveness of thyroid cancer histopathological type [41]. Fig.…”

Section: Discussionmentioning

confidence: 98%

MART-10, the vitamin D analog, is a potent drug to inhibit anaplastic thyroid cancer cell metastatic potential

et al. 2015

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Section: Discussionmentioning

confidence: 98%

MART-10, the vitamin D analog, is a potent drug to inhibit anaplastic thyroid cancer cell metastatic potential

et al. 2015

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“…This result suggests that the presence of concomitant HT decreases the aggressiveness of PTC by positively regulating E-cadherin expression. On the other hand , it was reported that E-cadherin expression is more associated with histopathological type of thyroid cancer than with the metastatic potential of tumours, and is not a predictor of extra-thyroidal growth of thyroid cancers [ 13 ]. In histological observation, the loss of E-cadherin expression may be involved in regional lymph node metastasis and in malignant potential of thyroid neoplasm [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand , it was reported that E-cadherin expression is more associated with histopathological type of thyroid cancer than with the metastatic potential of tumours, and is not a predictor of extra-thyroidal growth of thyroid cancers [ 13 ]. In histological observation, the loss of E-cadherin expression may be involved in regional lymph node metastasis and in malignant potential of thyroid neoplasm [ 19 , 20 ]. Several studies showed that N-cadherin can inhibit cell growth [ 21 , 22 ], and its overexpression was correlated with poor histological differentiation in tumours [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…The selective loss of E-cadherin can cause dedifferentiation and invasiveness in human carcinomas, indicating E-cadherin to be a classic tumour suppressor [ 12 ]. Some studies in thyroid cancer have demonstrated that differentiated cancers with a poorer prognosis present reduced E-cadherin expression, but its expression does predict the extra-thyroidal growth of thyroid cancers [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Papillary thyroid cancer with Hashimoto’s thyroiditis attenuates the tumour aggressiveness through the up-regulation of E-cadherin and TGF-β expression

et al. 2022

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Human papillary thyroid cancer (PTC) is often associated with Hashimoto’s thyroiditis (HT), and their coexistence improves the prognosis of PTC. Aim of the study. The objective of our study is to investigate the expression of cadherins and TGF-β which are regulators in the tumour aggressiveness with metastatic spread in PTC patients and its relationship with HT. The expression of E-cadherin and N-cadherin was measured in thyroid tissues of healthy volunteers and PTC patients with HT (PTC/HT) or without. The E-cadherin expression was also determined in thyroid cancer cells (TPC1, SNU373, SNU790, 8505C, CAL62, and FTC133). Cell migration was measured by wound healing assay. The expression of N-cadherin, ICAM1, and TGF-β was measured in thyroid tissues and plasma. The E-cadherin expression was significantly increased in PTC/HT patients compared with PTC alone. Meanwhile, the N-cadherin expression was significantly decreased in PTC/HT patients. The E-cadherin expression was only observed in FTC cells, and the overexpression of E-cadherin inhibited cancer cell migration. The TGF-β expression was significantly increased in PTC/HT patients, and the plasma levels were higher in PTC/HT patients than in PTC alone. The expression of N-cadherin and ICAM-1 was significantly decreased in PTC/HT patients. Our results indicate that the expression of E-cadherin and TGF-β was higher in PTC/HT patients than in PTC alone. This suggests that the presence of PTC with HT may attenuate the tumour aggressiveness and metastasis through the up-regulation of E-cadherin and TGF-β expression.

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Can We Predict Differentiated Thyroid Cancer Behavior? Role of Genetic and Molecular Markers

et al. 2021

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Thyroid cancer is ranked in ninth place among all the newly diagnosed cancer cases in 2020. Differentiated thyroid cancer behavior can vary from indolent to extremely aggressive. Currently, predictions of cancer prognosis are mainly based on clinicopathological features, which are direct consequences of cell and tissue microenvironment alterations. These alterations include genetic changes, cell cycle disorders, estrogen receptor expression abnormalities, enhanced epithelial-mesenchymal transition, extracellular matrix degradation, increased hypoxia, and consecutive neovascularization. All these processes are represented by specific genetic and molecular markers, which can further predict thyroid cancer development, progression, and prognosis. In conclusion, evaluation of cancer genetic and molecular patterns, in addition to clinicopathological features, can contribute to the identification of patients with a potentially worse prognosis. It is essential since it plays a crucial role in decision-making regarding initial surgery, postoperative treatment, and follow-up. To date, there is a large diversity in methodologies used in different studies, frequently leading to contradictory results. To evaluate the true significance of predictive markers, more comparable studies should be conducted.

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E-cadherin expression is more associated with histopathological type of thyroid cancer than with the metastatic potential of tumors

Cited by 4 publications

References 26 publications

MART-10, the vitamin D analog, is a potent drug to inhibit anaplastic thyroid cancer cell metastatic potential

MART-10, the vitamin D analog, is a potent drug to inhibit anaplastic thyroid cancer cell metastatic potential

Papillary thyroid cancer with Hashimoto’s thyroiditis attenuates the tumour aggressiveness through the up-regulation of E-cadherin and TGF-β expression

Can We Predict Differentiated Thyroid Cancer Behavior? Role of Genetic and Molecular Markers

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