E-cadherin expression in upper urothelial carcinoma in Balkan Endemic Nephropathy and non-endemic regions

Veličković, Ljubinka Janković; Hattori, Takanori; Visnjic, Milan; Dimov, Irena; Stojanović, Marko; Stefanović, Vladisav

doi:10.1016/j.prp.2009.03.007

Cited by 7 publications

(15 citation statements)

References 32 publications

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“…Unlike previous reports, no significant prognostic value for E-cadherin expression was identified herein [8,13,14,28]. In the Nakanishi et al [28] study, E-cadherin expression was associated with stage and grade, pattern of growth, disease-free, and overall survival rates only in univariate analysis.…”

Section: Discussioncontrasting

confidence: 67%

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Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma

Missaoui

Bdioui

Baccouche

et al. 2020

J Egypt Natl Canc Inst

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Background The study investigated the expression and the clinicopathological significance of p53, p27, Ki-67, E-cadherin, and HER2 in upper urinary tract urothelial carcinomas (UTUC) from Tunisian patients. We performed a retrospective study of 66 UTUC. Main clinicopathological features were reported. The expression of p53, p27, Ki-67, E-cadherin, and HER2 was investigated by immunohistochemistry on whole tissue section. Results Expression of p53, Ki-67, p27, E-cadherin, and HERE2 was reported in 36.4%, 69.7%, 90.9%, 100%, and 0% of cases, respectively. p53 expression was associated with stage (p = 0.001), positive surgical margin (p = 0.005), and shorter recurrence-free survival (RFS; Log Rank test, p = 0.026). Ki-67 and p27 expression was associated with stage (p < 0.001 and p = 0.001, respectively) and grade (p < 0.001 and p = 0.001, respectively). Using Kaplan-Meier test, the positive surgical margin was associated with shorter RFS compared to free surgical margin (Log Rank test, p = 0.031). Moreover, in univariate Cox regression analysis, surgical margin (p = 0.041; HR 0.325, 95% CI 0.110–0.956) and p53 expression (p = 0.035; HR 0.328, 95% CI 0.116–0.925) were the significant factors associated with RFS. Conclusions Together, our findings suggest that positive surgical margin and p53 expression were potential prognostic factors of UTUC since both were associated with shorter RFS in Tunisian patients.

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Section: Discussioncontrasting

confidence: 67%

“…Loss of E-cadherin expression is involved in tumor de-differentiation and invasiveness caused by the dissociation of cells from tissue structures [12]. The signification of E-cadherin in UTUC has been investigated by some contrasting studies [8,13,14].…”

Section: Introductionmentioning

confidence: 99%

Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma

Missaoui

Bdioui

Baccouche

et al. 2020

J Egypt Natl Canc Inst

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“…Our comparative study of E-cadherin expression in UUC between patients from BEN and nonendemic areas showed that BEN low-grade and low-stage tumors have important reduction of Ecadherin expression. The growth pattern had a predominant influence on E-cadherin expression in BEN tumors, as previously described [23]. Decreased E-cadherin expression is indicative for invasion and loss of local control.…”

Section: Ns No Significancesupporting

confidence: 72%

Molecular Markers in Upper Urothelial Carcinoma Associated to Balkan Endemic Nephropathy. Aristolochic Acid as the Major Risk Factor of the Worldwide Disease

Veličković

Hattori

Stefanović

2009

The Scientific World JOURNAL

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The role of aristolochic acid in the etiology of Balkan endemic nephropathy (BEN) and associated upper urothelial carcinoma (UUC) was recently confirmed. The aim of this study was to determine the marker(s) specific for BEN-associated UUC. A total of 82 patients with UUC (38 from the BEN region and 44 control tumors) were included in the study. The Ki-67 index in BEN tumors correlated with the grade and multifocality (p < 0.05), but in regression analysis, only the grade of BEN tumor. The p53 index was significantly higher in BEN than in control tumors (p < 0.05), as well as the alteration of p53 (p < 0.05). BEN low-stage tumors, tumors without limphovascular invasion (LVI), and tumors of the renal pelvis had a higher p53 index than the control tumors (p < 0.05, 0.01, 0.05, respectively). The Ki-67 index was higher in control tumors with high-stage and solid growth than in BEN UUC (p < 0.050, 0.005). The Ki-67 correlated with the grade, growth, stage, LVI, and multifocality of UUC on the best way, but not with the group. In regression analysis, only multifocality of UUC had predictive influence on Ki-67 activity (p < 0.001). P53 correlated with the grade, growth, and group (p < 0.05). This investigation identifies the p53 pathway as the specific cell cycle marker involved in BEN-associated UUC.

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“…These data contradict previous studies that have demonstrated that loss of E-cadherin is related to higher tumor stages and worse prognosis behavior in many cancers, including bladder tumors. In studies that specifically examined UUCs, Velickovic et al showed that, in sporadic urothelial carcinomas and in patients with Balkan endemic nephropathy, lower E-cadherin expression was correlated with higher tumor stages in both groups (18). However, some authors postulate that E-cadherin expression can be reversibly controlled by methylation (19).…”

Section: Discussionmentioning

confidence: 99%

Immune expression of E-cadherin and α, β and γ-Catenin adhesion molecules and prognosis for upper urinary tract urothelial carcinomas

et al. 2012

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ARTIcLE INFO _________________________________________________________ ___________________Introduction: Cell adhesion molecules (CAM) are required for maintaining a normal epithelial phenotype, and abnormalities in CAM expression have been related to cancer progression, including bladder urothelial carcinomas. There is only one study that correlates E-cadherin and α-, β-and γ-catenin expression with prognosis of upper tract urothelial carcinomas. Our aim is to study the pattern of immune expression of these CAMs in urothelial carcinomas from the renal pelvis and ureter in patients who have been treated surgically. Our goal is to correlate these expression levels and characteristics with well-known prognostic parameters for disease-free survival. Materials and Methods: We evaluated specimens from 20 patients with urothelial carcinomas of the renal pelvis and ureter who were treated with nephroureterectomy or ureterectomy between June 1997 and January 2007. CAM expression was evaluated by immunohistochemistry in a tissue microarray and correlated with histopathological characteristics and patient outcomes after a mean follow-up of 55 months. Results: We observed a relationship between E-cadherin expression and disease recurrence. Disease recurrence occurred in 87.5% of patients with strong E-cadherin expression. Only 50.0% of patients with moderate expression and 0% of patients with weak or no expression of E-cadherin had disease recurrence (p = 0.014). There was also a difference in disease-free survival. Patients with strong E-cadherin expression had a mean disease-free survival rate of 49.1 months, compared to 83.9 months for patients with moderate expression (p = 0.011). Additionally, an absence of α-catenin expression was associated with tumors that were larger than 3 cm (p = 0.003). Conclusions: We demonstrated for the first time that immune expression of E-cadherin is related to tumor recurrence and disease-free survival rates, and the absence of α-catenin expression is related to tumor size in upper tract urothelial carcinomas.

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E-cadherin expression in upper urothelial carcinoma in Balkan Endemic Nephropathy and non-endemic regions

Cited by 7 publications

References 32 publications

Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma

Significance of p53, p27, Ki-67, E-cadherin, and HER2 expression in upper urinary tract urothelial carcinoma

Molecular Markers in Upper Urothelial Carcinoma Associated to Balkan Endemic Nephropathy. Aristolochic Acid as the Major Risk Factor of the Worldwide Disease

Immune expression of E-cadherin and α, β and γ-Catenin adhesion molecules and prognosis for upper urinary tract urothelial carcinomas

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