E-cadherin expression and bromodeoxyuridine incorporation during development of ovarian inclusion cysts in age-matched breeder and incessantly ovulated CD-1 mice

Fleming, Jean S.; McQuillan, H James; Millier, Melanie J; Beaugié, Clare R.; Livingstone, Vicki

doi:10.1186/1477-7827-5-14

Cited by 12 publications

(17 citation statements)

References 48 publications

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“…Similar phenotypes have been observed in aged mice, transgenic mice, and ovarian diseases mouse models [39–41]. Specifically, one study showed that CD-1 mice develop ovarian inclusion cysts starting at 6 months of age, but enlarged ovarian cysts were observed in a 9 month old animal [39]. In a transgenic mouse model with conditionally activated Notch1, enlarged ovarian cysts developed in 8 month old animals [40].…”

Section: Discussionsupporting

confidence: 52%

“…The presence of ovarian cysts is often a sign of reproductive aging [38]. Similar phenotypes have been observed in aged mice, transgenic mice, and ovarian diseases mouse models [39–41]. Specifically, one study showed that CD-1 mice develop ovarian inclusion cysts starting at 6 months of age, but enlarged ovarian cysts were observed in a 9 month old animal [39].…”

Section: Discussionmentioning

confidence: 84%

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Prenatal exposure to an environmentally relevant phthalate mixture disrupts reproduction in F1 female mice

Zhou

Gao

Flaws

2017

Toxicology and Applied Pharmacology

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Phthalates are used in a large variety of products, such as building materials, medical devices, and personal care products. Most previous studies on the toxicity of phthalates have focused on single phthalates, but it is also important to study the effects of phthalate mixtures because humans are exposed to phthalate mixtures. Thus, we tested the hypothesis that prenatal exposure to an environmentally relevant phthalate mixture adversely affects female reproduction in mice. To test this hypothesis, pregnant CD-1 dams were orally dosed with vehicle (tocopherol-stripped corn oil) or a phthalate mixture (20 and 200 μg/kg/day, 200 and 500 mg/kg/day) daily from gestational day 10 to birth. The mixture was based on the composition of phthalates detected in urine samples from pregnant women in Illinois. The mixture included 35% diethyl phthalate, 21% di(2-ethylhexyl) phthalate, 15% dibutyl phthalate, 15% diisononyl phthalate, 8% diisobutyl phthalate, and 5% benzylbutyl phthalate. Female mice born to the exposed dams were subjected to tissue collections and fertility tests at different ages. Our results indicate that prenatal exposure to the phthalate mixture significantly increased uterine weight and decreased anogenital distance on postnatal days 8 and 60, induced cystic ovaries at 13 months, disrupted estrous cyclicity, reduced fertility-related indices, and caused some breeding complications at 3, 6, and 9 months of age. Collectively, our data suggest that prenatal exposure to an environmentally relevant phthalate mixture disrupts aspects of female reproduction in mice.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 84%

Prenatal exposure to an environmentally relevant phthalate mixture disrupts reproduction in F1 female mice

Zhou

Gao

Flaws

2017

Toxicology and Applied Pharmacology

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“…Some authors have suggested a secretory function of the rete ovarii in adults because secretory materials were observed in the lumen of the rete ovarii, which showed cystic changes in various species such as the cow, camel, cat, dog, and guinea pig (Byskov, 1975;Jiang et al 2004). Furthermore, some researchers have hypothesized that the rete ovarii is a common source of ovarian cysts and epithelial tumors in aged mice (Tan & Fleming, 2004;Tan et al 2005;Burdette et al 2007;Fleming et al 2007).…”

Section: Introductionmentioning

confidence: 99%

“…In a previous study, we reported a high incidence of ovarian cysts derived from the rete ovarii in the MRL ⁄ MpJ (MRL) mouse strain, a representative model for autoimmune diseases, including dermatitis, vasculitis, arthritis, and glomerulonephritis (Ichii et al 2008;Kon et al 2008). Ovarian cysts in CD-1 mice, another model for rete-derived ovarian cysts, showed epithelial malformations of cysts such as hyperplasia, metaplasia, stratification, and the appearance of lengthened columnar cells with compact cilia or vacuolated cytoplasm (Long, 2002;Fleming et al 2007). In contrast, the rete ovarian cysts of MRL mice showed dilation of the IR, which is mainly lined with a single-layered ciliated or non-ciliated squamous or cuboidal epithelium (Kon et al 2008), with considerably fewer pathological changes than the IR epithelium of CD-1 mice described by Long (2002).…”

Section: Introductionmentioning

confidence: 99%

Ovarian cysts in MRL / MpJ mice are derived from the extraovarian rete: a developmental study

et al. 2011

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MRL ⁄ MpJ (MRL) mice, commonly used as a model for autoimmune disease, have a high frequency of ovarian cysts originating from the rete ovarii. In the present study, to clarify how the rete ovarii, which are remnants of mesonephric tubules during embryogenesis, progress to cystic formation with aging, the morphology of MRL rete ovarii was analyzed and compared with that of normal C57BL ⁄ 6N (B6) mice. In B6 mice, the rete ovarii consisted of a series of tubules, including the extraovarian rete (ER), the connecting rete (CR), and the intraovarian rete (IR), based on their location. Whereas the ER of B6 mice was composed of highly convoluted tubules lined by both ciliated and non-ciliated epithelia, the tubules in the CR and IR had only non-ciliated cells. In MRL mice, dilations of the rete ovarii initiated from the IR rather than the ER or CR. Although the histological types of cells lining the lumen of the rete ovarii were the same as those in B6 mice, the ER in MRL mice showed a variety in morphology. In particular, the connections between the ER and ovary tended to disappear with increasing age and the development of ovarian cysts. Furthermore, the epithelium lining the large ovarian cysts in MRL mice had ciliated cells forming the cluster. On the basis of these findings, it is suggested that cystic changes of the rete ovarii in MRL mice are caused by the dilations of the IR with invasion of the ER and CR into the ovarian medulla. These data provide new pathological mechanisms for ovarian cyst formation.

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“…The histologic sections of the ovaries revealed an anovulatory phenotype; 5 of the 9 (55%) T-injected mice lacked a corpus luteum ( Table 2). Although epithelial inclusion cysts, which are commonly seen in old female mice (38), were observed in both T-injected and vehicle-treated mice, the T-injected mice had a higher frequency of epithelial inclusion cysts (55%) than CON mice ( Table 2). Although epithelial inclusion cysts, which are commonly seen in old female mice (38), were observed in both T-injected and vehicle-treated mice, the T-injected mice had a higher frequency of epithelial inclusion cysts (55%) than CON mice ( Table 2).…”

Section: Cyclicity and Ovarian Morphology (Table 2 And Figure 2)mentioning

confidence: 99%

The Effects of a Single Developmentally Entrained Pulse of Testosterone in Female Neonatal Mice on Reproductive and Metabolic Functions in Adult Life

et al. 2015

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Early postnatal exposures to sex steroids have been well recognized to modulate predisposition to diseases of adulthood. There is a complex interplay between timing, duration and dose of endocrine exposures through environmental or dietary sources that may alter the sensitivity of target tissues to the exogenous stimuli. In this study, we determined the metabolic and reproductive programming effects of a single developmentally entrained pulse of testosterone (T) given to female mice in early postnatal period. CD-1 female mice pups were injected with either 5 μg of T enanthate (TE) or vehicle (control [CON] group) within 24 hours after birth and followed to adult age. A total of 66% of T-treated mice exhibited irregular cycling, anovulatory phenotype, and significantly higher ovarian weights than vehicle-treated mice. Longitudinal nuclear magnetic resonance measurements revealed that TE group had greater body weight, whole-body lean, and fat mass than the CON group. Adipose tissue cellularity analysis in TE group revealed a trend toward higher size and number than their littermate CONs. The brown adipose tissue of TE mice exhibited white fat infiltration with down-regulation of several markers, including uncoupling protein 1 (UCP-1), cell death-inducing DNA fragmentation factor, α-subunit-like effector A, bone morphogenetic protein 7 as well as brown adipose tissue differentiation-related transcription regulators. T-injected mice were also more insulin resistant than CON mice. These reproductive and metabolic reprogramming effects were not observed in animals exposed to TE at 3 and 6 weeks of age. Collectively, these data suggest that sustained reproductive and metabolic alterations may result in female mice from a transient exposure to T during a narrow postnatal developmental window.

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E-cadherin expression and bromodeoxyuridine incorporation during development of ovarian inclusion cysts in age-matched breeder and incessantly ovulated CD-1 mice

Cited by 12 publications

References 48 publications

Prenatal exposure to an environmentally relevant phthalate mixture disrupts reproduction in F1 female mice

Prenatal exposure to an environmentally relevant phthalate mixture disrupts reproduction in F1 female mice

Ovarian cysts in MRL / MpJ mice are derived from the extraovarian rete: a developmental study

The Effects of a Single Developmentally Entrained Pulse of Testosterone in Female Neonatal Mice on Reproductive and Metabolic Functions in Adult Life

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