Dysuria at onset of interstitial cystitis/painful bladder syndrome in women

Warren, John W.; Diggs, Christina; Brown, Vivian; Meyer, W.; Markowitz, S.; Greenberg, Patty

doi:10.1016/j.urology.2006.03.036

Cited by 17 publications

(11 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5,7,19 It is generally recognized that women diagnosed as having painful bladder disorders frequently report a history of recurrent urinary tract infection; however, a consistent relationship between urinary infection and the onset of painful bladder disorders remains unproven. 20 The observations reported here suggest that significant changes in afferent sensitivity induced by bacterial cystitis associated with inflammation may contribute to perceived hypersensitivity to peripheral stimuli.…”

Section: Discussionmentioning

confidence: 64%

Bacterial Cystitis is Accompanied by Increased Peripheral Thermal Sensitivity in Mice

et al. 2008

View full text Add to dashboard Cite

Purpose-Visceral inflammation and pain associated with chemical cystitis produces increased sensitivity to noxious stimuli within with the sacral dermatomes. This study was performed to determine whether a similar sensitization occurs in response to bacterial cystitis.Materials and Methods-Bacterial cystitis was induced by intravesical instillation of E. coli 1677 in female C57BL/6N (C57) and C3H/OuJ (OuJ) mice. C3H/HeJ (HeJ) mice were used as a control because HeJ mice lack functional toll-like receptor 4 (Tlr4), an essential component of cellular recognition of bacterial lipopolysaccharide (LPS). Hindpaw sensitivity to a thermal stimulus was quantitatively determined 1, 2, 7 and 14 days after infection. Results-Intravesical instillation of E. coli produced infection in all strains of mice.Infection persisted in all OuJ and HeJ mice but spontaneously cleared in some C57 mice. Increased sensitivity to thermal stimuli was observed in C57 and OuJ, starting one to two days after E. coli instillation and still present 14 days after instillation. Increased sensitivity to thermal stimuli did not occur in C3H/HeJ mice.Conclusions-E. coli-induced cystitis produced increased sensitivity to peripheral thermal stimuli in mice with competent Tlr4.

show abstract

Section: Discussionmentioning

confidence: 64%

Bacterial Cystitis is Accompanied by Increased Peripheral Thermal Sensitivity in Mice

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Characteristics of this group have been outlined (11) . Worst symptoms were described as a median pain of 9 and urgency of 8; 119 (86%) had urinary frequency of ≥11/24 hours; and 98 (71%) described ≥3/night nocturia.…”

Section: Resultsmentioning

confidence: 99%

“…Consequently, we compared them by 97 variables clustered in the following sets: demographics (N=9); symptoms at onset, worst, and at present (17), sufficient medical records (3), findings at first medical encounter after symptom onset (14), findings at subsequent evaluations of their bladder disease (29), ICspecific therapy initially and ever (14), and medical history (11). Because of the large number of comparisons, we used a p-value of .01 to identify those with possibly significant differences.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Using the International Continence Society’s definition of painful bladder syndrome

Warren

Meyer

Greenberg

et al. 2006

Urology

Self Cite

View full text Add to dashboard Cite

Objectives-The case definition of interstitial cystitis (IC) is in flux. The International Continence Society (ICS) suggested a definition for the painful bladder syndrome (PBS), a concept embraced by many IC investigators, some of whom have used the name IC/PBS. In a study of recent onset IC/ PBS patients, we had two objectives: to determine 1) what proportion met the ICS definition and 2) how did those who met the definition differ from those who did not.Methods-Having recruited women who had recent onset IC/PBS for an ongoing case control study to identify its risk factors, we studied our first 138 eligible cases to identify those who met the ICS definition. We then compared those who met the definition to those who did not by variables acquired through interviews and medical records. The most liberal interpretation of the ICS definition did not include 47/138 (34%) of our cases. Comparing these to the 91 (66%) who did meet the ICS criteria, we found that 96/97 clinical variables, including many generally thought characteristic of IC/PBS, were not significantly different between the 2 groups. Results-The

show abstract

“…Detailed methods have been published. 5,6,10,11 After the baseline interview, each case was mailed a 45 page self-administered questionnaire which included numerous measures of symptoms and other aspects of IC/ PBS. A section in the questionnaire contained 23 statements about symptoms.…”

Section: Methodsmentioning

confidence: 99%

Voiding urges perceived by patients with interstitial cystitis/painful bladder syndrome

Greenberg

Brown

Yates

et al. 2007

Neurourology and Urodynamics

Self Cite

View full text Add to dashboard Cite

show abstract

Dysuria at onset of interstitial cystitis/painful bladder syndrome in women

Abstract: A slight majority of women with IC/PBS reported dysuria at onset of their IC/PBS symptoms. The available laboratory data have suggested that dysuria may be a sensitive indicator of urinary tract infection at the onset of IC/PBS; however, its specificity is as yet undetermined.

Cited by 17 publications

References 17 publications

Bacterial Cystitis is Accompanied by Increased Peripheral Thermal Sensitivity in Mice

Bacterial Cystitis is Accompanied by Increased Peripheral Thermal Sensitivity in Mice

Using the International Continence Society’s definition of painful bladder syndrome

Voiding urges perceived by patients with interstitial cystitis/painful bladder syndrome

Contact Info

Product

Resources

About