Dystrophin mRNA Processing in the Canine Homologue of Duchenne Muscular Dystrophy: An Authentic Model for Gene Therapy

Sharp, N. C. C.; Kornegay, Joe N.; Camp, Steven D. Van; Herbstreith, Michael H.; Secore, Susan; Kettle, Susan; Dykstra, Michael J.; Constantinou, Constantinos D.; Roses, Allen D.; Bartlett, Richard J.

doi:10.1007/978-3-642-84842-1_12

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2021

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“…There are several animal models used in DMD research, including the mdx mouse and the Golden Retriever Muscular Dystrophy (GRMD) dog. The GRMD dog model (with a splice site mutation in intron 6) has historically been the most widely used canine model of DMD [7][8][9][10]. Beagle crosses (with the same mutation) have been created to develop a separate, smaller line of dogs in Japan, known as CXMD J [11].…”

Section: Introductionmentioning

confidence: 99%

Musculoskeletal magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy

Hornby

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Harron

et al. 2021

Neuromuscular Disorders

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