Dystonic reactions to phenothiazine derivatives.

Cyclophosphamide Therapy in the Nephrotic Syndrome in Childhood

“…Severe anorexia and vomiting necessitated interruption of treatment in only two patients. Three children receiving prochlorperazine as an antiemetic developed dystonia, which has previously been 'described in association with this drug (Cottom and Newman, 1966). Three children experienced transient chemical cystitis during treatment and two developed jaundice, which appeared to be due to infective hepatitis.…”

Pathophysiology and Pharmacotherapy of Spasmodic Torticollis: A Review

“…In 20 cases of acute phenothiazine toxicity in childhood, four had torticollis (Gupta and Lovejoy, 1967). These dystonic reactions responded rapidly to anticholinergic agents (DiMascio et al, 1976), antihistamines (Gupta and Lovejoy, 1967;Cottom and Newman, 1966), which are also potent anticholinergic agents, as well as to the indirectly acting DA receptor agonists, amantadine (DiMascio et al, 1976) and methylphenidate (Fann, 1966).…”

Dystonic Reactions in Children Caused by Metoclopramide

“…Our first patient raised the suspicion of toxicity to metoclopramide because she developed the extrapyramidal symptoms known to occur after phenothiazines (Ayd, 1961;Cottom and Newman, 1966;Gupta and Lovejoy, 1967). This idea was confirmed by the occurrence of identical dystonic reactions in 4 other patients receiving metoclopramide.…”

“…Presenting a very distressing 'cyclic torticollis' for more than one year, he was seen by several doctors before the reason for his dystonic symptoms was elucidated. (Cottom and Newman, 1966). Gupta and Lovejoy (1967) treated these cases by intravenous administration of diphenhydramine (Benadryl), and in most of their cases there was a striking response to this treatment.…”