Dysregulatory processes of the cellular link of the immune system in the dynamics of common variable immunodeficiency

Sizyakinа, L. P.; Andreeva, I I; Danilova, Daria I.

doi:10.51620/0869-2084-2021-66-3-160-165

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…Актуальность. Особенностью сегодняшнего дня является общее снижение популяционного иммунитета человечества, что в первую очередь проявляется ростом количества инфекционных заболеваний человек, и в первую очередь гнойновоспалительных [1,5].…”

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Clinical Efficacy of Inclusion of the Metabolite Mesxidol in the Regimen of Treatment of Inflammatory Diseases Complicated by the Development of Purulent Processes

Zemskova

2023

Bulletin of the Central Chernozem Region

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The clinical effectiveness of two therapy regimens of patients with one of the diseases pyoderma, adnexitis or soft tissue infection complicated by purulent processes was assessed. The first scheme provided for the use of basic therapy according to clinical recommendations, the second was supplemented by the metabolist Mexidol. The results of analysis of pharmacotherapy of 162 patients divided into groups according to the nosological affiliation of diseases and subhorupa according to the therapy regimen were used. It has been found that the additional prescription of Mexidol metabolic to patients to the standard significantly increases the effectiveness of complex treatment.

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Clinical Efficacy of Inclusion of the Metabolite Mesxidol in the Regimen of Treatment of Inflammatory Diseases Complicated by the Development of Purulent Processes

Zemskova

2023

Bulletin of the Central Chernozem Region

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Characteristics of the parameters of the innate and acquired immune response during the period of adaptation to training at a Medical University

et al. 2021

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Adaptation for new social conditions is an inevitable factor which the first-year students undergo when entering a medical school. Immune system as a part of entire structural and functional homeostatic complex, is involved into the adaptive reactions, thus pointing to its participation in fitting the new lifestyle among first-year students. One should note some peculiarities of immune reactions which depend on the organization pattern of educational process: despite common features of studies, the training environment for beginners at the military training center (VTC) is different from those for students at the medical and preventive faculty (LPF). The purpose of our study was to compare quantitative and functional parameters of immune system in the first-year students at a medical university, depending on distinct features of educational arrangement.The study included 36 first-year students of the Medical University divided into two groups, comparable for age, sex, and physical condition. The first group included 18 first-year VUTS students, whereas the second group consisted of 18 LPF pupils. Studies of immunological parameters in peripheral blood were carried out three months after the training was started. We have assessed counts and functional potential of T cells, their subpopulation profile, B lymphocyte counts, and serum level of IgA, IgM and IgG, total numbers of natural killer cells and proportion of cytolytically active forms, oxygen-producing activity of neutrophils, and the numbers of peripheral monocytes expressing type 2,4 Toll-like receptors (TLR). Comparison of the adaptive immune response parameters did not reveal any gross differences between the groups. At the same time, evaluation of markers reflecting functional potential of innate immunity cells revealed distinct signs of immune reactions, depending on the faculty of the first-year students. It has been shown that the proportion of functionally active NK-cells containing lytic granzyme B granules was lower in the EUTC students. Also, military medical students have a statistically significantly lower relative and absolute number of peripheral blood monocytes expressing surface TLR 4. The detected signs of suppressed functional potential of macrophages and natural killer cells in the first-year OUV students represent the possibly alarming factor of impaired adaptive reserves of immune system. The data obtained are of interest for development of immune rehabilitation programs to prevent clinical manifestations of immune dysfunction.

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Dynamics of immune system parameters in development of SARS-CoV-2-specific immunity in a patient with common variable immune deficiency

Sizyakinа

Andreeva

Kharitonova

2022

Russian Journal of Immunology

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With the accumulation of data on the evolving SARS-CoV-2 infection pandemic, it became clear that the risk factors for severe course of COVID-19 among the patients with primary immunodeficiency include disorders associated with dysregulation of the immune response. In this regard, it is of interest to identify possible predictors of the pronounced inflammatory reaction upon infection with coronavirus in the patients with general variable immune insufficiency. For this purpose, the dynamics of immune system parameters was studied in a patient with CVID who underwent a severe clinical variant of COVID-19, as an example of clinical case. We present patient K., 49 years old, with CVID diagnosis verified at the age of 35 years who received regular replacement therapy with IVIG. He suffered from COVID-19 in severe form, received anti-cytokine therapy and an additional course of IVIG during the treatment. He was discharged in satisfactory condition. The quantitative and functional parameters of the T and B lineages of immune system were evaluated by flow cytofluorimetry during routine examinations before the infection and three months after the discharge from the hospital after COVID-19. It has been shown that, before the disease, there were changes in the parameters of B cells characteristic of CVID manifesting as a decrease in switched-memory B cells and plasmoblasts. Alterations in the T cell subsets were also revealed, as redistribution of the subpopulation composition towards T effectors with an increased cytolytic potential of these cells and a weakening of T cell suppression, due to decreased Treg in peripheral blood. After undergoing COVID-19, the patient developed specific IgM and IgG antibodies. The development of immune response was accompanied by an increase in the number of un-switched and switched memory B cells. At the same time, we have registered an increase in memory T cells ready for the proliferative response of T helper cells and Treg cells. The initial pro-inflammatory pattern of the T cell lineage system in our patient with CVID is explained by the implementation of the compensatory capabilities of the immune system, thus leading to activation of the cytolytic effects of cellular compartment in adaptive immune response, along with attenuation of the humoral component. Moreover, it is likely that these changes contributed to the clinical course of COVID-19 in this clinical case. Development of a specific humoral response to SARS-CoV-2 in a patient with CVID after a COVID-19 infection is accompanied by an increased proportion of memory B cells, coordinated dynamics of T cell suppression and activation parameters.

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Dysregulatory processes of the cellular link of the immune system in the dynamics of common variable immunodeficiency

Cited by 3 publications

References 18 publications

Clinical Efficacy of Inclusion of the Metabolite Mesxidol in the Regimen of Treatment of Inflammatory Diseases Complicated by the Development of Purulent Processes

Clinical Efficacy of Inclusion of the Metabolite Mesxidol in the Regimen of Treatment of Inflammatory Diseases Complicated by the Development of Purulent Processes

Characteristics of the parameters of the innate and acquired immune response during the period of adaptation to training at a Medical University

Dynamics of immune system parameters in development of SARS-CoV-2-specific immunity in a patient with common variable immune deficiency

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