Dysregulation of VEGF-induced proangiogenic Ca2+ oscillations in primary myelofibrosis-derived endothelial colony-forming cells

Dragoni, Silvia; Reforgiato, Marta; Zuccolo, Estella; Poletto, Valentina; Lodola, Francesco; Ruffinatti, Federico Alessandro; Bonetti, Elisa; Guerra, Germano; Barosi, Giovanni; Rosti, Vittorio; Moccia, Francesco

doi:10.1016/j.exphem.2015.09.002

Cited by 46 publications

(69 citation statements)

References 47 publications

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“…We have shown that percutaneous TCE is effective and safe for the treatment of disease relapse. Diagnosis of PAVMs may be intriguing as clinical, physiopatological and radiological characteristics may mimic other cardio-respiratory diseases arising from different cellular and biomolecular pathways [1,3,23–40]. Percutaneous TCE is recognized as the gold standard for treatment of PAVM due to its efficacy and safety in reducing the risk of paradoxical embolism and other complications associated with PAVM [41–45].…”

Section: Discussionmentioning

confidence: 99%

A case of Multiple Unilateral Pulmonary arteriovenous Malformation Relapse: Efficacy of embolization treatment

et al. 2015

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Pulmonary arteriovenous Malformations (PAVMs) are a rare vascular alteration characterized by abnormal communications between the pulmonary arteries and veins resulting in an extracardiac right-to-left (R-L) shunt. The majority of PAVMs are associated with an autosomal dominant vascular disorder also known as Osler-Weber-Rendu Syndrome. PAVMs appearance can be both single and multiple. Clinical manifestations include hypoxemia, dyspnea cyanosis, hemoptysis and cerebrovascular ischemic events or abscesses. We report a case of an 18 year old female with severe respiratory failure caused by a relapse of multiple unilateral pulmonary arterovenous fistula. Symptoms at admission include dyspnea, cyanosis and clubbing. The patient underwent pulmonary angio-TC scan, brain CT and echocardiography. The thoracic angio-CT scan showed the presence of PAVMs of RUL and RLL; a marked increase of right bronchial artery caliber and its branches with an aneurismatic dilatation was also observed. The patient underwent percutaneous transcatheter embolization using Amplatzer Vascular Plug IV; a relevant clinical and functional improvement was subsequently recorded. Embolization is effective in the treatment of relapsing PAVMS.

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Section: Discussionmentioning

confidence: 99%

A case of Multiple Unilateral Pulmonary arteriovenous Malformation Relapse: Efficacy of embolization treatment

et al. 2015

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“…EPCs are derived either from the bone marrow and/or the arterial wall to replace dysfunctional endothelial cells [8–12]. EPCs play a pivotal role in blood perfusion of ischemic and tumoral tissues using different mechanisms [13–23]. …”

Section: Discussionmentioning

confidence: 99%

Our experience of liver Epithelioid Hemangioendothelioma: from a misdiagnosis to liver transplantation with long term follow-up

et al. 2015

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Malignant Hepatic Epithelioid hemangioendothelioma (HEHE) is an uncommon vascular tumor of intermediate malignant potential. HEHE is a rare tumor and it is difficult to diagnose for surgeons, hepatologists, radiologists and pathologists. So, misdiagnosis with a delay of the treatment is not uncommon.We describe a case of a young woman with a diagnosis of HEHE made 6 years after the first evidence of liver mass with a very long term follow-up after surgical treatment.She had two diagnoses of Hepatocellurar carcinoma (HCC) and a diagnosis of Cholangiocarcinoma after three different fine needle biopsies. After clinical observation, a new laparoscopic core biopsy was performed. In a first time approach, considering clinical and radiological patterns, a diagnosis of Budd-Chiari Syndrome was finally made.For that the patient underwent an orthotopicliver transplantation (OLTx).The surgical sample histological analysis allowed a definitive diagnosis of HEHE.At last, at follow up 7 years after three OLTx the patient is still alive and in good health with no evidence of recurrence.

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“…Endothelial progenitor cells (EPCs) could be injected and utilizing several Ca 2+ mediated mechanisms restore the vascular network in vivo [41–50]. …”

Section: Discussionmentioning

confidence: 99%

Bowel Angiodysplasia and Myocardial Infarction secondary to an ischaemic imbalance: a case report

et al. 2015

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Angiodysplasia, defined as a vascular ectasia or arteriovenous malformation, is the most frequent cause of occult bleeding in patients older than 60 years and a significant association with several cardiac condition is described. Patients with anemia and negative findings on upper endoscopy and colonoscopy should be referred for further investigation of the small bowel. The investigation of choice, when available, is wireless capsule endoscopy. Several therapeutic options are available in this cases, as we reviewed in this report. We report a case of 78-year old man admitted to our Intensive Coronary Unit for dyspnea and chest pain. A diagnosis of non-ST-segment elevation acute coronary syndrome was made and a concomintant, significant anemia was found (hemoglobin 8.2 g/dl).No cororary disease was found by an angiography though the past medical history revealed systemic hypertension, chronic kidney disease (KDOQY stage III), and diabetes mellitus type II on insuline therapy. A Wireless Video capsule examination was positive for jejunum angiodysplasia and an argon plasma coagulation was chosen as terapeutic option. No subsequent supportive therapy and interventions were required in subsequent one year of follow-up.

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Dysregulation of VEGF-induced proangiogenic Ca2+ oscillations in primary myelofibrosis-derived endothelial colony-forming cells

Cited by 46 publications

References 47 publications

A case of Multiple Unilateral Pulmonary arteriovenous Malformation Relapse: Efficacy of embolization treatment

A case of Multiple Unilateral Pulmonary arteriovenous Malformation Relapse: Efficacy of embolization treatment

Our experience of liver Epithelioid Hemangioendothelioma: from a misdiagnosis to liver transplantation with long term follow-up

Bowel Angiodysplasia and Myocardial Infarction secondary to an ischaemic imbalance: a case report

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