Dysregulation of the mesoprefrontal dopamine circuit mediates an early-life stress-induced synaptic imbalance in the prefrontal cortex

Oh, Won Chan; Rodrı́guez, Gabriela; Asede, Douglas; Jung, Kanghoon; Hwang, In-Wook; Ogelman, Roberto; Bolton, M. McLean; Kwon, Hyung Bae

doi:10.1016/j.celrep.2021.109074

Cited by 12 publications

(4 citation statements)

References 50 publications

(66 reference statements)

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“…Several neural pathways and neurobiological mechanisms such as the hypothalamic-pituitary-adrenal (HPA) axis and extrahypothalamic corticotropin-releasing factor (CRF) circuits have been identified by which ELS may increase the risk for mood dysregulation, stress-related disorders and addiction (Nemeroff, 2016). Emerging evidence now suggests that ELS-induced alterations of reward-and stress-related brain regions such as ventral tegmental area (VTA), amygdala, nucleus accumbens, prefrontal cortex and LHb may underlie the increased risk for ELS-induced psychopathology (Authement et al, 2015(Authement et al, , 2018Peña et al, 2017Peña et al, , 2019Tchenio et al, 2017;Bolton et al, 2018a;Simmons et al, 2020;Langlois et al, 2021;Oh et al, 2021;Shepard and Nugent, 2021). Specifically, recent studies provided compelling evidence that the LHb is a critical converging brain region for ELS-induced dysregulation of reward circuits (Tchenio et al, 2017;Authement et al, 2018;Bolton et al, 2018b;Simmons et al, 2020).…”

Section: Lateral Habenula Represents a Key Node For Increased Risk Of...mentioning

confidence: 99%

Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders

Baker

Mathis

Lecourtier

et al. 2022

Front. Syst. Neurosci.

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In this Perspective review, we highlight some of the less explored aspects of lateral habenula (LHb) function in contextual memory, sleep, and behavioral flexibility. We provide evidence that LHb is well-situated to integrate different internal state and multimodal sensory information from memory-, stress-, motivational-, and reward-related circuits essential for both survival and decision making. We further discuss the impact of early life stress (ELS) on LHb function as an example of stress-induced hyperactivity and dysregulation of neuromodulatory systems within the LHb that promote anhedonia and motivational deficits following ELS. We acknowledge that recent technological advancements in manipulation and recording of neural circuits in simplified and well-controlled behavioral paradigms have been invaluable in our understanding of the critical role of LHb in motivation and emotional regulation as well as the involvement of LHb dysfunction in stress-induced psychopathology. However, we also argue that the use of ethologically-relevant behaviors with consideration of complex aspects of decision-making is warranted for future studies of LHb contributions in a wide range of psychiatric illnesses. We conclude this Perspective with some of the outstanding issues for the field to consider where a multi-systems approach is needed to investigate the complex nature of LHb circuitry interactions with environmental stimuli that predisposes psychiatric disorders.

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Section: Lateral Habenula Represents a Key Node For Increased Risk Of...mentioning

confidence: 99%

Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders

Baker

Mathis

Lecourtier

et al. 2022

Front. Syst. Neurosci.

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“…Furthermore, MS may cause changes in the function of brain regions, such as emotional regulation and cognitive control [ 55 ]. Several studies have also found that MS may alter the structure of brain cells, such as the number and density of synapses, morphology, and number of neurons [ 56 , 57 ]. The effect of MS on stress reactivity.…”

Section: Discussionmentioning

confidence: 99%

Global research trends on maternal separation paradigms as an early life stress model: A bibliometric analysis

Meng,

Bao,

Yue

2023

Heliyon

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“…The association between higher perceived stress and poorer attention observed in Val/val participants could be the result of heightened dopaminergic activity in the prefrontal cortex (PFC). This is supported by evidence that stress increases dopaminergic activity in the PFC to the point of cognitive impairment (Finlay et al, 1995;Murphy et al, 1996;Oh et al, 2021;Roth et al, 1988) and dopaminergic hyperfunctioning throughout mesocorticolimbic pathways has been linked to inattention (Viggiano et al, 2003;Zhuang et al, 2001). Although studies of a direct role of val66met in the mesocortical pathway are limited, there is evidence that met-carrying individuals exhibit reduced dopamine transmission in the nucleus accumbens (Pecina et al, 2014).…”

Section: The Val/met Genotype Buffers the Association Between Stress ...mentioning

confidence: 94%

The brain‐derived neurotrophic factor Val66met polymorphism is associated with better attention and working memory performance and resilience to mild chronic stress

Corrone,

Nanev,

Amato

et al. 2023

Eur J of Neuroscience

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The val66met polymorphism of the brain‐derived neurotrophic factor (BDNF) gene has been identified as a potential moderator for the relationship between chronic stress and executive functioning. However, whether the presence of the met allele increases cognitive vulnerability or resilience to stress has yet to be determined. Given the established effects of autonomic activity and psychological arousal on executive functioning, in the present study, 56 healthy university students completed self‐report measures of chronic stress, positive arousal (vigour) and negative arousal (anxiety) and measured heart‐rate variability to quantify autonomic activity. Participants then completed a cognitive test battery that measured attention, decision‐making, visual learning and working memory. Regression analyses demonstrated that Val/met participants performed better on attention and working memory tasks than Val/val participants, but no differences were seen in decision‐making and visual learning. Further, Val/met participants were protected from stress‐related differences in attention seen in Val/val participants. Val66met was not associated with physiological or psychological arousal. This study demonstrates that val66met plays an important but selective role in cognitive performance.

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Dysregulation of the mesoprefrontal dopamine circuit mediates an early-life stress-induced synaptic imbalance in the prefrontal cortex

Cited by 12 publications

References 50 publications

Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders

Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders

Global research trends on maternal separation paradigms as an early life stress model: A bibliometric analysis

The brain‐derived neurotrophic factor Val66met polymorphism is associated with better attention and working memory performance and resilience to mild chronic stress

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