Dysregulation of Stress Erythropoiesis and Enhanced Susceptibility to Salmonella Typhimurium Infection in Aryl Hydrocarbon Receptor–Deficient Mice
Michelle Mayer,
Sevgi C Cengiz-Dartenne,
Manja Thiem
et al.
Abstract:Background
By acting as an environmental sensor, the ligand-induced transcription factor aryl hydrocarbon receptor (AhR) regulates acute innate and adaptive immune responses against pathogens. Here, we analyzed the function of AhR in a model for chronic systemic infection with attenuated Salmonella Typhimurium (STM).
Methods
WT and AhR-deficient mice were infected with the attenuated STM strain TAS2010 and analyzed for bacter… Show more
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