Dysregulation of Placental Endothelial Lipase and Lipoprotein Lipase in Intrauterine Growth-Restricted Pregnancies

Gauster, Martin; Hiden, Ursula; Blaschitz, Astrid; Frank, Saša; Lang, Uwe; Alvino, G.; Cetin, Irene; Desoyé, Gernot; Wadsack, Christian

doi:10.1210/jc.2006-2403

Cited by 104 publications

(80 citation statements)

References 33 publications

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“…Thus, a higher birth weight for GDM-exposed offspring would have been expected. However, similar associations (LPL mRNA levels were inversely correlated with birth weight) were reported in intrauterine growth restriction (IUGR) placentas, 28,29 although these results are controversial. 30,31 These studies suggested that LPL gene expression is regulated by the in utero environment, possibly in a IUGR severity-dependent manner.…”

Section: Discussionmentioning

confidence: 74%

Placental lipoprotein lipase DNA methylation alterations are associated with gestational diabetes and body composition at 5 years of age

et al. 2017

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Gestational diabetes mellitus (GDM) is associated with obesity in childhood. This suggests that consequences of in utero exposure to maternal hyperglycemia extend beyond the fetal development, possibly through epigenetic programming. The aims of this study were to assess whether placental DNA methylation (DNAm) marks were associated with maternal GDM status and to offspring body composition at 5 years old in a prospective birth cohort. DNAm levels were measured in the fetal side of the placenta in 66 samples (24 from GDM mothers) using bisDNA-pyrosequencing. Anthropometric and body composition (bioimpedance) were measured in children at 5 years of age. Mann-Whitney and Spearman tests were used to assess associations between GDM, placental DNAm levels at the lipoprotein lipase (LPL) locus and children's weight, height, body mass index (BMI), body fat, and lean masses at 5 years of age. Weight, height, and BMI z-scores were computed according to the World Health Organization growth chart. Analyses were adjusted for gestational age at birth, child sex, maternal age, and pre-pregnancy BMI. LPL DNAm levels were positively correlated with birth weight z-scores (r D 0.252, P D 0.04), and with midchildhood weight z-scores (r D 0.314, P D 0.01) and fat mass (r D 0.275, P D 0.04), and negatively correlated with lean mass (r D ¡0.306, P D 0.02). We found a negative correlation between LPL DNAm and mRNA levels in placenta (r D ¡0.459; P < 0.001), which highlights the regulation of transcriptional activity by these epivariations. We demonstrated that alterations in fetal placental DNAm levels at the LPL gene locus are associated with the anthropometric profile in children at 5 years of age. These findings support the concept of fetal metabolic programming through epigenetic changes.

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Section: Discussionmentioning

confidence: 74%

Placental lipoprotein lipase DNA methylation alterations are associated with gestational diabetes and body composition at 5 years of age

et al. 2017

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“…This difference might be related to inadequate placental function, similar to what was previously reported for other nutrients in IUGR (8 -10). Possible mechanism responsible for the altered LC-PUFA profile could be changes in lipoprotein intake and degradation, and/or in fatty acids binding proteins (30,31). A potential bias of these data is related to the different gestational age at the time of CS in IUGR compared with control pregnancies.…”

Section: Discussionmentioning

confidence: 99%

“…Increases of NEFA and triglycerides in the fetal circulation of only IUGR-PE could be the reflection of changes in placental lipase activities (31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43) in this pathological condition characterized by placental insufficiency but also by a vascular damage in which the atherogenic role of lipids and lipoperoxidation have been well established (18).…”

Section: Discussionmentioning

confidence: 99%

Maternal and Fetal Fatty Acid Profile in Normal and Intrauterine Growth Restriction Pregnancies With and Without Preeclampsia

et al. 2008

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ABSTRACT:The aim of this study was to evaluate maternal and fetal lipid profile in intrauterine growth restriction (IUGR) pregnancies with and without preeclampsia (PE). Thirteen normal pregnancies studied during the third trimester (control M) and 29 at elective cesarean section (control CS) were compared with 18 pregnancies complicated by IUGR (IUGR only) and with seven pregnancies complicated by both IUGR and PE (IUGR-PE). Total plasma fatty acids, triglycerides, cholesterol, and nonesterified fatty acids (NEFA) were determined in maternal and fetal plasma. Nutritional intake was analyzed. IUGR only mothers had lower percentage of linoleic acid (LA) and higher arachidonic acid (AA) than controls, partly explained by higher AA dietary intake. Higher levels of NEFA were observed both in IUGR only and in IUGR-PE mothers whereas triglyceride levels were increased in IUGR-PE mothers only. In IUGR-PE fetuses, LA and AA were significantly decreased, whereas triglyceride and NEFA concentrations were significantly increased compared with normal fetuses. In conclusion, IUGR only is associated with altered fatty acids profile not completely accounted by dietary changes. We hypothesize that the differences observed in IUGR with PE for triglycerides and other lipids could be related to a difference in maternal phenotype. (Pediatr Res 64: 615-620, 2008)

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“…To be transported to the fetal circulation, lipids have to be hydrolyzed to small and simple molecules. Lipases, such as lipoprotein lipase (LPL) and endothelial lipase (EL), are key proteins expressed on the surface of trophoblast cells, where they hydrolyze esterified lipids from lipoproteins, so that they can be acquired by the placenta (Herrera et al 1987, Gauster et al 2007. Expression and activity of these transporters is a limiting step in lipid transport through the placenta to the fetus (Jones et al 2007, Duttaroy 2009).…”

Section: Introductionmentioning

confidence: 99%

Saturated fat-rich diet increases fetal lipids and modulates LPL and leptin receptor expression in rat placentas

Mazzucco

Higa

Capobianco

et al. 2013

Journal of Endocrinology

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Metabolic alterations in obese and overweight mothers impact the placenta and the fetus, leading to anomalies in fetal growth and lipid accretion. The primary aim of the study was to examine the effect of a saturated fat-rich diet (FD) on growth, lipid accretion, and lipases, leptin and leptin receptor (ObR) expression in the placenta and fetal liver. We also aimed to find a role for fetal leptin in the modulation of placental and fetal liver lipase and ObR expression. Six-week-old rats were fed with a standard rat chow (control) or a 25% FD for 7 weeks until mating and during pregnancy. Also, in a group of control rats, fetuses were injected with leptin on days 19, 20, and 21 of pregnancy. On day 21, we assessed lipidemia, insulinemia, and leptinemia in mothers and fetuses. In the placenta and fetal liver, lipid concentration was assessed by thin layer chromatography (TLC) and the gene expression of lipoprotein lipase (LPL), endothelial lipase, insulin receptor (Insr), leptin, and ObR by RT-PCR. The FD induced hypertriglyceridemia and hyperleptinemia (P!0.01) in mothers and fetuses, an increase in maternal (P!0.05) and fetal weight (P!0.01), overaccumulation of lipids in fetal liver (P!0.01), and enhanced leptin expression in the placenta and fetal liver (P!0.05). Placental expression of IR and LPL was increased (P!0.05), and ObR decreased (P!0.05) in the FD group. Fetal administration of leptin induced the placental and fetal liver downregulation of ObR (P!0.05) and upregulation of LPL expression (P!0.05). The FD led to increased fetal lipid levels, which may result from high maternal lipid availability and fetal leptin effects. Key Words" Saturated fat-rich diet

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Dysregulation of Placental Endothelial Lipase and Lipoprotein Lipase in Intrauterine Growth-Restricted Pregnancies

Abstract: EL is the predominant TLG family member in the human placenta present at both interfaces. EL and LPL are dysregulated in IUGR.

Cited by 104 publications

References 33 publications

Placental lipoprotein lipase DNA methylation alterations are associated with gestational diabetes and body composition at 5 years of age

Placental lipoprotein lipase DNA methylation alterations are associated with gestational diabetes and body composition at 5 years of age

Maternal and Fetal Fatty Acid Profile in Normal and Intrauterine Growth Restriction Pregnancies With and Without Preeclampsia

Saturated fat-rich diet increases fetal lipids and modulates LPL and leptin receptor expression in rat placentas

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