Dysregulation of miR-637 serves as a diagnostic biomarker in patients with carotid artery stenosis and predicts the occurrence of the cerebral ischemic event

Abstract

Dysregulation of miR-637 serves as a diagnostic biomarker in patients with carotid artery stenosis and predicts the occurrence of the cerebral ischemic event

microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician’s Perspective

“…In line with this, miR-637 was assessed as a potential biomarker of ICAS and IS occurrence [ 122 ]. The prospective analysis revealed that down-regulation of miR-637 was associated with the degree of ICAS, with a sensitivity of 85.6%, and a specificity of 83.3% for ICAS of at least 50% lumen narrowing [ 122 ].…”

“…In line with this, miR-637 was assessed as a potential biomarker of ICAS and IS occurrence [ 122 ]. The prospective analysis revealed that down-regulation of miR-637 was associated with the degree of ICAS, with a sensitivity of 85.6%, and a specificity of 83.3% for ICAS of at least 50% lumen narrowing [ 122 ]. During the 5 year follow-up, the Kaplan–Meier analysis showed that the lower miR-637 levels were associated with a higher incidence of ICAS-related IS (HR = 0.073, 95% CI = 0.017–0.313, p < 0.001), along with severe ICAS (HR = 0.144, 95% CI = 0.045–0.463, p = 0.001) [ 122 ].…”

“…The prospective analysis revealed that down-regulation of miR-637 was associated with the degree of ICAS, with a sensitivity of 85.6%, and a specificity of 83.3% for ICAS of at least 50% lumen narrowing [ 122 ]. During the 5 year follow-up, the Kaplan–Meier analysis showed that the lower miR-637 levels were associated with a higher incidence of ICAS-related IS (HR = 0.073, 95% CI = 0.017–0.313, p < 0.001), along with severe ICAS (HR = 0.144, 95% CI = 0.045–0.463, p = 0.001) [ 122 ]. The study proved that the miR-637 downregulation is responsible for cardiovascular events in patients with atherosclerosis [ 137 ] by promoting the proliferation and migration of VSMCs by regulating IGF-2 [ 138 ].…”

“…The other study by Zhang et al focused on miR-637 and its possible role as a biomarker for IS risk [ 122 ]. The multivariate analysis revealed that downregulation of miR-637 independently predicted future IS (HR = 0.073, 95%CI = 0.017–0.313, p < 0.001), thus making the analyzed miRs possible biomarkers in ICAS patients [ 122 ].…”

Differential expression profile of miRNAs between stable and vulnerable plaques of carotid artery stenosis patients

“…For example, Jeong et al (2021) reported miR-33a-5p, miR-33b-5p and miR-148a-3p as candidate biomarkers of CS because they bind directly to ATP binding cassette transporter 1 (ABCA1). Liu et al (2021) showed that miR-28-5p alleviated CS by modulating vascular smooth muscle cell proliferation and migration. Zhang and Liu (2021) found that serum miR-637 was considerably reduced in CS patients, and its downregulation was a potential biomarker for the diagnosis of CS and a valuable predictor of cerebral ischemic events.…”