Dysregulation of immunity by cigarette smoking promotes inflammation and cancer: A review

Liu, Yubin; Lu, Lan; Yang, Huan; Wu, Xu; Luo, Xinyue; Shen, Jing; Xiao, Zhangang; Zhao, Yueshui; Du, Fukuan; Chen, Yu; Deng, Shuai; Cho, Chi Hin; Li, Qianxiu; Li, Xiaobing; Li, Wanping; Wang, Fang; Sun, Yuhong; Gu, Li; Chen, Meijuan; Li, Mingxing

doi:10.1016/j.envpol.2023.122730

Cited by 16 publications

(7 citation statements)

References 210 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results showed that current smoking was associated with higher risk of SIRS, which is consistent with the published literatures [ 27 ]. Smoking could induce an excess production of inflammatory mediators and lead to systemic immune dysfunction [ 28 ]. HCT is one of the critical biomarkers for the diagnosis of anemia and also a critical biomarker in several inflammatory diseases such as sepsis and malignant tumors [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Postoperative SIRS after thermal ablation of HCC: Risk factors and short-term prognosis

Peng,

Xing,

Zou

et al. 2024

Heliyon

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Postoperative SIRS after thermal ablation of HCC: Risk factors and short-term prognosis

Peng,

Xing,

Zou

et al. 2024

Heliyon

View full text Add to dashboard Cite

“…54 Other environmental factors influence the development of IBD, such as sterility, 55 antibiotics, and other appendectomies and smoking. [56][57][58] In general, environmental factors trigger IBD mainly by disrupting the balance of the intestinal microbiome, and another possible cause is the destruction of intestinal epithelial cells.…”

Section: Environmental Factormentioning

confidence: 99%

Mesenchymal Stromal Cells: New Generation Treatment of Inflammatory Bowel Disease

Wei,

Li,

Wang

et al. 2024

JIR

Self Cite

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, which has a high recurrence rate and is incurable due to a lack of effective treatment. Mesenchymal stromal cells (MSCs) are a class of pluripotent stem cells that have recently received a lot of attention due to their strong self-renewal ability and immunomodulatory effects, and a large number of experimental and clinical models have confirmed the positive therapeutic effect of MSCs on IBD. In preclinical studies, MSC treatment for IBD relies on MSCs paracrine effects, cell-to-cell contact, and its mediated mitochondrial transfer for immune regulation. It also plays a therapeutic role in restoring the intestinal mucosal barrier through the homing effect, regulation of the intestinal microbiome, and repair of intestinal epithelial cells. In the latest clinical trials, the safety and efficacy of MSCs in the treatment of IBD have been confirmed by transfusion of autologous or allogeneic bone marrow, umbilical cord, and adipose MSCs, as well as their derived extracellular vesicles. However, regarding the stable and effective clinical use of MSCs, several concerns emerge, including the cell sources, clinical management (dose, route and frequency of administration, and pretreatment of MSCs) and adverse reactions. This article comprehensively summarizes the effects and mechanisms of MSCs in the treatment of IBD and its advantages over conventional drugs, as well as the latest clinical trial progress of MSCs in the treatment of IBD. The current challenges and future directions are also discussed. This review would add knowledge into the understanding of IBD treatment by applying MSCs.

show abstract

“…Each e-cigarette cartridge typically contains approximately 11.9 mg of nicotine [ 5 ]. By incorporating nicotine complexes into e-cigarette liquids, it becomes possible to facilitate smoking cessation [ 6 ] and mitigate both individual and public health risks associated with traditional cigarette consumption [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Extraction and Purification of Nicotine from Tobacco Rhizomes by Supercritical CO2

Zheng,

Xie,

Ren

et al. 2024

Molecules

View full text Add to dashboard Cite

Currently, in the ongoing development of the tobacco industry, a large amount of tobacco rhizomes is discarded as waste. These wastes are usually disposed of through incineration or burial. However, these tobacco wastes still have some economic value. High-purity nicotine has a promising market outlook as the primary raw material for electronic cigarette liquid. Nicotine is not only found in tobacco leaves but also in the rhizomes of tobacco plants. This study presents a method for treating tobacco waste and extracting high-purity nicotine from it. After mixing the raw material powder and entrainer in specific ratios, as much of the nicotine in tobacco roots can be extracted as possible using supercritical carbon dioxide extraction. The effects of temperature, the ratio of the entrainer, and the volume fraction of ethanol in the entrainer on the nicotine yield in supercritical fluid extraction (SFE) at 25 MPa for 120 min were discussed. By using 90% ethanol (a raw material mass-to-volume ratio of 1:5) as the entrainer, we obtained the highest nicotine yield of 0.49% at 65 °C. Meanwhile, the purity of the crude extract was 61.71%, and after purification, it increased to 97.57%. In this way, we can not only obtain nicotine with market value but also further reduce the harm to the environment caused by tobacco waste disposal.

show abstract

Dysregulation of immunity by cigarette smoking promotes inflammation and cancer: A review

Cited by 16 publications

References 210 publications

Postoperative SIRS after thermal ablation of HCC: Risk factors and short-term prognosis

Postoperative SIRS after thermal ablation of HCC: Risk factors and short-term prognosis

Mesenchymal Stromal Cells: New Generation Treatment of Inflammatory Bowel Disease

Extraction and Purification of Nicotine from Tobacco Rhizomes by Supercritical CO2

Contact Info

Product

Resources

About