Dysregulation of gut health in zebrafish by differentially charged nanoplastic exposure: an integrated analysis of histopathology, immunology, and microbial informatics

Xu, Zhimin; Zhang, Yuxue; Xu, Zhihao; Zhong, Yuming; Wang, Lei; Chen, Ailing; Jiang, Shaojun; Sun, Weimin; Yu, Guohui; Li, Yanling; Li, Chengzhang; Wang, Yifan; Yu, Renqiang; Zhang, Le

doi:10.1039/d2en00542e

Cited by 6 publications

(4 citation statements)

References 72 publications

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“…Importantly, Lianguo Chen et al (2018) found that the toxicity of titanium dioxide nanoparticles and bisphenol A exposure in zebrafish is associated with the gastrointestinal microbiome, with the combined exposure leading to oxidative stress closely related to the ratio of pathogenic Lawsonia and normal metabolic Hyphomicrobium ( Chen et al, 2018 ). Recent research findings indicate that the ingestion of differentially charged nanoplastics leads to the development of inflammatory lesions in the gut, disruption of electron transfer processes, inhibition of energy metabolism during mitochondrial oxidative phosphorylation, oxidative stress, increased expression of pro-inflammatory factors, and disturbances in pathways related to glycolipid metabolism ( Xu et al, 2023 ). Our findings highlight that zebrafish is the predominant model organism in environmental toxicity studies.…”

Section: Discussionmentioning

confidence: 99%

Global trends and hotspots of gastrointestinal microbiome and toxicity based on bibliometrics

Duan,

Liu,

Bai

et al. 2023

Front. Microbiol.

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BackgroundToxicity concerns persist in the fields of public health, environmental science, and pharmacology. The intricate and vital role of the gastrointestinal microbiome in influencing toxicity and overall human health has gained increasing recognition in recent years. This study presents a comprehensive bibliometric analysis to evaluate the global scientific output, emerging trends, and research focal points in the area of gastrointestinal microbiome and toxicity.MethodsThe Web of Science Core Collection database was retrieved for publications on the gastrointestinal microbiome and toxicity from 1980 to 2022. Our analysis included scholarly research papers written in English and excluded duplicate publications. We used Biblioshiny and R to summarize the count and citation metrics of included articles, and visualized research trends and keywords. CiteSpace was used to identify reference literature, keywords, and citation bursts. VOSviewer was used to visualize the network of related countries, institutions, authors, co-cited authors, and keywords.ResultsA total of 2,140 articles were included, allowing us to identify significant countries, institutions, authors, and research focal points. Our results indicate a growing trend in the field, with China and the United States leading the research. The most productive journal in this area is Science of the Total Environment. Key findings revealed that research hotspots have shifted from drugs to environmental pollutants, emphasizing microplastics. Important mechanisms studied include oxidative stress, metabolism, inflammation, and apoptosis, with target organs being the gastrointestinal tract, liver, and brain. Furthermore, we highlight the rising significance of the gut-brain axis and the usage of zebrafish as a model organism.ConclusionDespite certain limitations, such as focusing solely on English-language publications and excluding unpublished literature, our findings provide valuable insights into the current state of research on toxicity and the gastrointestinal microbiome. In the future, modifications to the gastrointestinal microbiome could offer new directions for treating and mitigating toxicity. These discoveries provide a comprehensive perspective on the broader scope of this research field.

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Section: Discussionmentioning

confidence: 99%

Global trends and hotspots of gastrointestinal microbiome and toxicity based on bibliometrics

Duan,

Liu,

Bai

et al. 2023

Front. Microbiol.

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“…Additionally, the XPS spectra of Cu 2p in CuZn consist of two characteristic peaks and two satellite peaks. The spectra at 936.06 eV and 953.22 eV of the sample correspond to the characteristic peaks of Cu 0 [36]. Cu 0 in ZIF-8 can form a bimetallic synergistic effect with Zn 2+ and exhibits good redox properties.…”

Section: Xps Analysis Of Cuzn Nanocomposites Smentioning

confidence: 91%

“…This aspect is crucial for the enhanced electrochemical detection performance of CuZn in contrast to pure ZIF-8. In the high-resolution N 1s spectrum (Figure 6e), two peaks are evident: 398.95 eV for pyridine-N and 399.4 eV for pyrrole-N, indicating the synthesis of ZIF-8 [36].…”

Section: Xps Analysis Of Cuzn Nanocomposites Smentioning

confidence: 99%

Transition metal doped ZIF‐8 for the detection of the heavy metal Hg(II)

Chen,

Wu,

et al. 2024

J Chinese Chemical Soc

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The effects of heavy metals such as Hg(II) and Pb(II) on the human body are profound. Moreover, they pose significant concerns due to industrial development. Thus, the rapid and stable detection of heavy metal ions and related chemicals has emerged as an urgent issue. The application of Differential Pulse Stripping Voltammetry (DPSV) facilitated accurate and rapid detection of Hg2+ utilizing MOF materials and ZIF‐8 as detection agents. Pure ZIF‐8 served as the substrate material. Copper or nickel ions were individually introduced into the substrate material. This process resulted in the formation of bimetallic MOF materials. These materials were designated as CuZn and NiZn, respectively. Transition metal‐doped materials were used to modify the glassy carbon electrode (GCE), resulting in a substantial enhancement in the detection performance of Hg2+. The CuZn/GCE configuration demonstrated the most significant enhancement. When compared to a GCE modified with pure ZIF‐8, both sensitivity and the detection limit for free Hg2+ in the environment experienced increases of 450% and 64%, respectively. Stability and repeatability tests were conducted on the CuZn‐modified GCE. Results indicated that the electrode proved to be very stable and showed strong selectivity in the presence of interfering ions. The sensor modified with CuZn shows promising potential for monitoring trace Hg2+ levels.

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“…18,21,23,27 NPs are created through aged plastic by processes like ultraviolet radiation and microbial degradation, resulting in variations in surface functional groups and surface charges. 28,29 However, there is a limited understanding of the effects of NPs on the transmission of ARGs. Among the few examples, Sheng et al found that exposure to NPs or co-exposure to antibiotics and NPs increased the diversity of ARGs in the soil invertebrate Enchytraeus crypticus.…”

Section: Introductionmentioning

confidence: 99%

Charged nanoplastics differentially affect the conjugative transfer of antibiotic resistance genes

Wang

Liang

et al. 2023

Environ. Sci.: Nano

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Dysregulation of gut health in zebrafish by differentially charged nanoplastic exposure: an integrated analysis of histopathology, immunology, and microbial informatics

Abstract: Differential charged nanoplastics (NPs; different surface functional groups) engendered by plastic aging widely existed in water environment, yet minimal was known about their bio-enrichment characteristics and toxicity effects. Here, the...

Cited by 6 publications

References 72 publications

Global trends and hotspots of gastrointestinal microbiome and toxicity based on bibliometrics

Global trends and hotspots of gastrointestinal microbiome and toxicity based on bibliometrics

Transition metal doped ZIF‐8 for the detection of the heavy metal Hg(II)

Charged nanoplastics differentially affect the conjugative transfer of antibiotic resistance genes

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