Dysregulation of gastric H,K-ATPase by cigarette smoke extract

Hammadi, Muna; Adi, Mohamed; John, Rony; Khoder, Ghalia; Karam, Sherif M.

doi:10.3748/wjg.15.3416

Cited by 4 publications

(5 citation statements)

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“…Cigarette smoke extract was shown to increase the amount Table 3 Each row shows the odds ratio (OR) and 95% confidence interval for a logistic regression model with parietal cell autoantibodies as the dependent variable, after adjusting the effect of the independent variables for age and sex. and activity of H + /K + -ATPase in the mouse gastric mucosa [22], and there is evidence that the development of H + /K + -ATPase tolerance may be attributable to peripheral mechanisms [7]. In mice, the presence of the endogenous antigen promotes T cell tolerance to H + /K + -ATPase [23]; when smoking increases this enzyme, it may thus facilitate increased tolerance to the autoantigen.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with parietal cell autoantibodies in the general population

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Factors associated with parietal cell autoantibodies in the general population

et al. 2012

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“…The causes of smoking-associated changes in microbiome composition are likely a combination of environmental, host and microbial changes such as intestinal and immune disruption, impaired clearance of pathogens 84,85 , acidification of gastric contents 86 and ingestion of bacteria that occur in cigarettes 87 . Furthermore, cigarette smoke can directly affect the virulence of both bacteria 88 and fungi 89 , as well as altering the growth and exopolysaccharide structure of known gut bacteria such as Bifidobacterium animalis 90 , which may contribute to dysbiosis.…”

Section: [H3] Microbiota and Copdmentioning

confidence: 99%

Emerging pathogenic links between microbiota and the gut–lung axis

et al. 2016

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The microbiota is vital for the development of the immune system and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the respiratory tract and the gut have recently been linked to alterations in immune responses and to disease development in the lungs. In this Opinion article, we review the microbial species that are usually found in healthy gastrointestinal and respiratory tracts, their dysbiosis in disease and interactions with the gut-lung axis. Although the gut-lung axis is only beginning to be understood, emerging evidence indicates that there is potential for manipulation of the gut microbiota in the treatment of lung diseases.

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“…(Firmicutes) in the colon, with alteration in inflammatory gene expression. 231 These data highlight a possible role for CS in gut microbiome shaping with unknown consequences in the evolution of inflammation-related disorders such as IBD.…”

mentioning

confidence: 89%

“…Among them, the following should be mentioned: epigenetic susceptibility, modulation of mucosal immune response, alterations in intestinal cytokine and eicosanoid levels, modification of gut permeability with consequent impaired clearance of pathogen alteration in the H þ /K þ -ATPase pump with consequential acidification of gastric contents, and ingestion of the bacteria present in cigarettes. [227][228][229][230]231,232 Human studies targeting selected bacterial groups have reported that smoking patients with active CD have increased abundances of Bacteroides and Prevotella…”

Section: Ibd Microbiome and Lifestyle Factorsmentioning

confidence: 99%

Exploring the microbiome in health and disease

Scotti

Boué

Sasso

et al. 2017

Toxicology Research and Application

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The analysis of human microbiome is an exciting and rapidly expanding field of research. In the past decade, the biological relevance of the microbiome for human health has become evident. Microbiome comprises a complex collection of microorganisms, with their genes and metabolites, colonizing different body niches. It is now well known that the microbiome interacts with its host, assisting in the bioconversion of nutrients and detoxification, supporting immunity, protecting against pathogenic microbes, and maintaining health. Remarkable new findings showed that our microbiome not only primarily affects the health and function of the gastrointestinal tract but also has a strong influence on general body health through its close interaction with the nervous system and the lung. Therefore, a perfect and sensitive balanced interaction of microbes with the host is required for a healthy body. In fact, growing evidence suggests that the dynamics and function of the indigenous microbiota can be influenced by many factors, including genetics, diet, age, and toxicological agents like cigarette smoke, environmental contaminants, and drugs. The disruption of this balance, that is called dysbiosis, is associated with a plethora of diseases, including metabolic diseases, inflammatory bowel disease, chronic obstructive pulmonary disease, periodontitis, skin diseases, and neurological disorders. The importance of the host microbiome for the human health has also led to the emergence of novel therapeutic approaches focused on the intentional manipulation of the microbiota, either by restoring missing functions or eliminating harmful roles. In the present review, we outline recent studies devoted to elucidate not only the role of microbiome in health conditions and the possible link with various types of diseases but also the influence of various toxicological factors on the microbial composition and function.

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Dysregulation of gastric H,K-ATPase by cigarette smoke extract

Cited by 4 publications

References 0 publications

Factors associated with parietal cell autoantibodies in the general population

Factors associated with parietal cell autoantibodies in the general population

Emerging pathogenic links between microbiota and the gut–lung axis

Exploring the microbiome in health and disease

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