Dysregulation of apoptosis is a major mechanism in the lymph node involvement in colorectal carcinoma

Bandrés, Eva; Catalan, Victoria; Sola, Iosu; Honorato, Beatriz; Cubedo, Elena; Cordeu, Lucía; Andion, Esther; Escalada, Alvaro; Zárate, Ruth; Salgado, Esteban; Zabalegui, Natalia; García, Francisco Javier González; Garcı́a-Foncillas, Jesús

doi:10.3892/or.12.2.287

Cited by 15 publications

(14 citation statements)

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“…There have so far been few studies predicting lymph node metastasis in colorectal cancer. [12][13][14][15] However, these previous studies had several limitations, such as a small number of patients, a low sensitivity of the model, or a lack of validation of these models in an independent set of patients. We herein examined a large number of patients and validated the accuracy of the predictive model in a test set of patients and the accuracy of the model compared with previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7][8][9][10][11] Several studies have explored the possibility of predicting lymph node metastases in colorectal cancer patients. [12][13][14][15] However, these studies examined only a small number of patients, or otherwise the validation of the predictive model was not performed in a separate test sample set of patients (between 12 and 21 patients). We have recently reported that gene expression profiles can predict the presence of lymph node metastases in colorectal cancer patients.…”

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confidence: 99%

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Gene Expression of Mesenchyme Forkhead 1 (FOXC2) Significantly Correlates With the Degree of Lymph Node Metastasis in Colorectal Cancer

Watanabe

Kobunai

Yamamoto

et al. 2011

International Surgery

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In stage III colorectal cancer, patients with N1 stage tumors show poorer outcome than patients with N2 stage tumors. Our objective was to identify genes that are predictive for the presence of lymph node metastasis, and to characterize the aggressiveness of lymph node metastases. Gene expression profiles of colorectal cancer were determined by microarray in training (n = 116) and test (n = 25) sets of patients. We identified 40 discriminating probes in patients with and without lymph node metastases. Using these probes, we could predict the presence of lymph node metastasis with an accuracy of 87.1% (training set) and 76.0% (test set). Among discriminating probes, FOXC2

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Gene Expression of Mesenchyme Forkhead 1 (FOXC2) Significantly Correlates With the Degree of Lymph Node Metastasis in Colorectal Cancer

Watanabe

Kobunai

Yamamoto

et al. 2011

International Surgery

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“…Interestingly, TM4SF1 , a member of the transmembrane 4 superfamily, was upregulated in the metastases group. This antigen is known to be highly expressed in several cancer types, including CRC [22,35], and increased level of TM4SF1 has been associated with development of metastases and poor clinical outcome in patients with lung cancer [36]. …”

Section: Discussionmentioning

confidence: 99%

Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses

et al. 2007

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Background: Despite the fact that metastases are the leading cause of colorectal cancer deaths, little is known about the underlying molecular changes in these advanced disease stages. Few have studied the overall gene expression levels in metastases from colorectal carcinomas, and so far, none has investigated the peritoneal carcinomatoses by use of DNA microarrays. Therefore, the aim of the present study is to investigate and compare the gene expression patterns of primary carcinomas (n = 18), liver metastases (n = 4), and carcinomatoses (n = 4), relative to normal samples from the large bowel.

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“…Gene expression analysis of colorectal biopsies using high density oligonucleotide microarrays could help detect such gene expression profiles that would establish the basis for new molecular diagnostic methods, and efforts have been made in this direction. In order to understand the gene expression background of CRC progression and metastasis development, many previous studies have primarily focused on the pair-wise comparisons of discriminative mRNA expression signatures between CRC and normal colorectal mucosa (NOR) samples, between CRA and NOR samples, as well as between the early and advanced stages of CRC (15)(16)(17)(18)(19)(20)(21)(22)(23)(24). Results from various studies have demonstrated that CRC and/or CRA have widespread genetic alterations compared to NOR (25)(26)(27).…”

Section: Identification Of An Intermediate Signature That Marks the Imentioning

confidence: 99%

Identification of an intermediate signature that marks the initial phases of the colorectal adenoma-carcinoma transition

Tang

Guo²,

Chao³

et al. 2010

Int J Mol Med

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Abstract. The colorectal adenoma-carcinoma sequence describes the stepwise progression from normal to dysplastic epithelium and then to carcinoma. Only a small proportion of colorectal adenomas (CRAs) progress to colorectal carcinomas (CRCs). Endoscopic intervention is currently being used on patients with high grade dysplasia CRAs, with diameters of >1 cm, or villous components of >25% who are at higher risk than other CRA sufferers. During the process, biopsy samples are taken for conventional histological diagnosis, but poor pathomorphological sensitivity and specificity greatly limit the diagnostic accuracy. Unfortunately, there are no reliable molecular criteria available that can predict the potential development of CRA to CRC. Gene expression profiles of normal colorectal mucosa (NOR), CRA and different Dukes' stages of CRC biopsy specimens, which represent the gradual progress of the CRA to CRC sequence, were determined by Affymetrix technology. Representative regulated genes were further analyzed by quantitative real-time PCR (qRT-PCR) and immunohistochemistry (IHC). Intersectional analyses of discriminative expression signatures of CRC vs. CRA and CRA vs. NOR allowed the identification of an intermediate signature of 463 probe sets (psets) that mark the NOR➝ CRA➝CRC progression. This signature represents a reservoir of candidate markers for the early diagnosis of higher-risk CRA, thus allowing for timely therapeutic intervention and more selective treatment. A further 279 CRC-specific psets pointing to the malignant transition from CRA to CRC were identified and these could represent potential therapeutic targets for CRC. The reliability of the results was further confirmed by qRT-PCR and IHC analyses of the 4-gene sets randomly selected from the 463 psets.

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Dysregulation of apoptosis is a major mechanism in the lymph node involvement in colorectal carcinoma

Cited by 15 publications

References 0 publications

Gene Expression of Mesenchyme Forkhead 1 (FOXC2) Significantly Correlates With the Degree of Lymph Node Metastasis in Colorectal Cancer

Gene Expression of Mesenchyme Forkhead 1 (FOXC2) Significantly Correlates With the Degree of Lymph Node Metastasis in Colorectal Cancer

Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses

Identification of an intermediate signature that marks the initial phases of the colorectal adenoma-carcinoma transition

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