Abstract:Notch signaling plays an important role in arterial‐venous specification during embryogenesis. However, the role of Notch signaling in lymphatic development is poorly understood. Here, we show that activated Notch and its downstream effectors, Hey1 and Hey2, repress the expression of the master control gene of lymphatic development Prox1 and induce arterial phenotypes in human lymphatic endothelial cells (LECs). We then translated our findings to define the molecular basis for the disturbed lymphatic developme… Show more
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