Dysregulated fatty acid metabolism in coronary ectasia: An extended lipidomic analysis

Boles, Usama; Pinto, Rui; David, Santosh; Abdullah, Abdullah Sayied; Henein, Michael Y.

doi:10.1016/j.ijcard.2016.11.093

Cited by 11 publications

(12 citation statements)

References 18 publications

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“…After 12 weeks of whole-body vibration, the main metabolites involved in changes in the glycerol phospholipid metabolism pathway were phosphatidylcholine and phosphatidylethanolamine in the skeletal muscle of ageing mice. The abnormal metabolism of phosphatidylcholine is closely related to the abnormal regulation of blood glucose [28], atherosclerosis [29], and stroke [30], mostly because phosphatidylcholine can prevent injury induced by antioxidant enzymes and reduce the inflammatory response of cells [31]. Lysophosphatidylcholine is a degradation product of phos- phatidylcholine.…”

Section: Discussionmentioning

confidence: 99%

Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice

et al. 2020

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Ageing increases the occurrence and development of many diseases. Exercise is believed to be an effective way to improve ageing and skeletal muscle atrophy. However, many elderly people are unable to engage in active exercise. Whole-body vibration is a passive way of moving that is especially suitable for the elderly and people who find it inconvenient to exercise. Metabolomics is the systematic study of metabolic changes in small molecules. In this study, metabolomics studies were performed to investigate the regulatory effect of whole-body vibration on the skeletal muscles of ageing mice. After 12 weeks, we found that whole-body vibration had the most obvious effect on lipid metabolism pathways (such as linoleic acid, α-linolenic acid metabolism, glycerophospholipid metabolism pathways) in skeletal muscle of ageing mice. Through further research we found that whole-body vibration decreased the levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol and very low-density lipoprotein in blood; decreased the lipid deposition in skeletal muscle; decreased the protein expression of monocyte chemoattractant protein-1 and interleukin-6; improved the protein levels of phosphorylated insulin receptor substrate-1, phosphate phosphoinositide 3-kinase and p-AKT; improved the protein levels of klotho; and decreased the protein expression of p53. These findings reveal that whole-body vibration might postpone senility by attenuating lipid deposition and reducing chronic inflammation and the insulin resistance of skeletal muscle.

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Section: Discussionmentioning

confidence: 99%

Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice

et al. 2020

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“…These results establish an interesting link with our previously published lipidomic profiling data, which showed lower sphingomyelins (SM) levels in CAE patients compared to controls. Low SM levels reduce lipoprotein aggregation engulfed by activated macrophages, resulting in fewer macrophage foam cell, the main component in atheroma, and hence less atheroma formation [ 5 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Family history of premature CAD was noted if a male first-degree relative aged <55 or a female first-degree relative aged <65 developed CAD. Patients were classified as smokers if they had smoked during the last six months [ 5 , 24 ]. No CAE patient had documented inflammatory pathology at the time of the study, i.e., inflammation related to high atherosclerosis burden or connective tissue diseases, (Ehlers–Danlos syndrome, Kawasaki disease, and polycystic kidney disease), iatrogenic coronary aneurysms, or Takayasu arteritis, and this may have suggested a causal relationship for the CAE lesion.…”

Section: Methodsmentioning

confidence: 99%

“…The exact pathogenesis of CAE is not well established [ 3 ]. It is attributed to atherosclerosis in 50% of cases based on its common association [ 4 ], but recent extended lipidomic profiling has provided evidence against this [ 5 ]. Up to 20% of CAE cases are considered congenital, and 10–20% are associated with inflammatory or connective tissue diseases, e.g., Ehlers–Danlos syndrome, Kawasaki disease, and polycystic kidney disease [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Cytokine Disturbances in Coronary Artery Ectasia Do Not Support Atherosclerosis Pathogenesis

Boles

Johansson

Wiklund

et al. 2018

IJMS

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Background: Coronary artery ectasia (CAE) is a rare disorder commonly associated with additional features of atherosclerosis. In the present study, we aimed to examine the systemic immune-inflammatory response that might associate CAE. Methods: Plasma samples were obtained from 16 patients with coronary artery ectasia (mean age 64.9 ± 7.3 years, 6 female), 69 patients with coronary artery disease (CAD) and angiographic evidence for atherosclerosis (age 64.5 ± 8.7 years, 41 female), and 140 controls (mean age 58.6 ± 4.1 years, 40 female) with normal coronary arteries. Samples were analyzed at Umeå University Biochemistry Laboratory, Sweden, using the V-PLEX Pro-Inflammatory Panel 1 (human) Kit. Statistically significant differences (p < 0.05) between patient groups and controls were determined using Mann–Whitney U-tests. Results: The CAE patients had significantly higher plasma levels of INF-γ, TNF-α, IL-1β, and IL-8 (p = 0.007, 0.01, 0.001, and 0.002, respectively), and lower levels of IL-2 and IL-4 (p < 0.001 for both) compared to CAD patients and controls. The plasma levels of IL-10, IL-12p, and IL-13 were not different between the three groups. None of these markers could differentiate between patients with pure (n = 6) and mixed with minimal atherosclerosis (n = 10) CAE. Conclusions: These results indicate an enhanced systemic pro-inflammatory response in CAE. The profile of this response indicates activation of macrophages through a pathway and trigger different from those of atherosclerosis immune inflammatory response.

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“…Another study showed 142 % more chance of CAE in the HTN group [28]. In contrast, a study expressed ineffective HTN on CAE [29] or the other study showed the prospective effect of HTN on CAE [30]. To the best of our knowledge, there is no metaanalysis study to show this relation.…”

Section: Introductionmentioning

confidence: 91%

Hypertension and coronary artery ectasia: a systematic review and meta-analysis study

et al. 2021

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Background Coronary artery ectasia (CAE) is characterized by the enlargement of a coronary artery to 1.5 times or more than other non-ectasia parts of the vessel. It is important to investigate the association of different factors and CAE because there are controversial results between available studies. We perform this systematic review and meta-analysis to evaluate the effects of hypertension (HTN) on CAE. Methods To find the potentially relevant records, the electronic databases, including Scopus, PubMed, and Science Direct were searched on 25 July 2019 by two of the authors independently. In the present study, the pooled odds ratio (OR) accompanied by 95 % confidence intervals (CIs) were calculated by a random-effects model. Heterogeneity presented with the I2 index. Subgroup analysis and sensitivity analysis by the Jackknife approach was performed. Results Forty studies with 3,263 cases and 7,784 controls that investigated the association between HTN and CAE were included. The pooled unadjusted OR of CAE in subjects with HTN in comparison by subjects without HTN was estimated 1.44 (95 % CI, 1.24 to 1.68) with moderate heterogeneity (I2 = 41 %, Cochran’s Q P = 0.004). There was no evidence of publication bias in the analysis of HTN and CAE with Egger’s test (P = 0.171), Begg’s test (P = 0.179). Nine articles reported the adjusted effect of HTN on CAE by 624 cases and 628 controls. The findings indicated the overall adjusted OR was 1.03 (95 % CI, 0.80 to 1.25) with high heterogeneity (I2 = 58.5 %, Cochran’s Q P = 0.013). Conclusions We found that when the vessel was in normal condition, HTN was not very effective in increasing the chance of CAE and only increased the CAE chance by 3 %. This is an important issue and a warning to people who have multiple risk factors together. More studies need to be performed to further establish these associations by reported adjusted effects.

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Dysregulated fatty acid metabolism in coronary ectasia: An extended lipidomic analysis

Cited by 11 publications

References 18 publications

Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice

Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice

Cytokine Disturbances in Coronary Artery Ectasia Do Not Support Atherosclerosis Pathogenesis

Hypertension and coronary artery ectasia: a systematic review and meta-analysis study

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