Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities

Stroope, Chad; Nettersheim, Felix Sebastian; Coon, Brian; Finney, Alexandra C.; Schwartz, Martin A.; Ley, Klaus; Rom, Oren; Yurdagul, Arif

doi:10.1038/s42255-024-01015-w

Nat Metab

2024

DOI: 10.1038/s42255-024-01015-w

|View full text |Cite

Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities

Chad Stroope,

Felix Sebastian Nettersheim,

Brian Coon

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article4

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 355 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The complex interplay between ferroptosis and atherosclerosis

Zhang,

Li,

2024

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

The complex interplay between ferroptosis and atherosclerosis

Zhang,

Li,

2024

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

Transcriptome-centric approach to the derivation of adverse outcome pathway networks of vascular dysfunction after long-term low-level exposure of human endothelial cells to dibutyl phthalate

Stanic,

Kokai,

Opacic

et al. 2024

Science of The Total Environment

View full text Add to dashboard Cite

In Situ Mapping of the Glucose Metabolism Heterogeneity in Atherosclerosis: Correlation With 2-Deoxyglucose Uptake

Haddad,

Demirdelen,

Barnes

et al. 2024

Mol Imaging

View full text Add to dashboard Cite

Objective 2-Deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) is widely used for noninvasive imaging of atherosclerosis. However, knowledge about metabolic processes underlying [18F]FDG uptake is mostly derived from in vitro cell culture studies, which cannot recapitulate the complexities of the plaque microenvironment. Here, we sought to address this gap by in situ mapping of the activity of selected major dehydrogenases involved in glucose metabolism in atherosclerotic plaques. Methods In situ activity of lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G6PD), succinate dehydrogenase (SDH), and isocitrate dehydrogenase (IDH) was assessed in plaques from murine aortic root and brachiocephalic arteries and human carotid arteries. High-resolution 2-deoxy-D-[1,2-3H]glucose ([3H]2-deoxyglucose) autoradiography of murine brachiocephalic plaques was performed. Results LDH activity was heterogeneous throughout the plaques with the highest activity in medial smooth muscle cells (SMCs). G6PD activity was mostly confined to the medial layer and to a lesser extent to SMCs along the fibrous cap. SDH and IDH activities were minimal in plaques. Plaque regions with increased [3H]2-deoxyglucose uptake were associated with a modestly higher LDH, but not G6PD, activity. Conclusions Our study reveals a novel aspect of the metabolic heterogeneity of the atherosclerotic plaques, enhancing our understanding of the complex immunometabolic biology that underlies [18F]FDG uptake in atherosclerosis.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities

Cited by 4 publications

References 355 publications

The complex interplay between ferroptosis and atherosclerosis

The complex interplay between ferroptosis and atherosclerosis

Transcriptome-centric approach to the derivation of adverse outcome pathway networks of vascular dysfunction after long-term low-level exposure of human endothelial cells to dibutyl phthalate

In Situ Mapping of the Glucose Metabolism Heterogeneity in Atherosclerosis: Correlation With 2-Deoxyglucose Uptake

Contact Info

Product

Resources

About