Dysplastic Squamous Cells Are Frequently Present in Urine Cytology Specimens of Patients with High-Grade Urothelial Carcinoma

Sojitra, Payal; Venkataraman, Girish; Masoom, Saeedeh; Kapur, Umesh; Wojcik, Eva M.

doi:10.1159/000337644

Cited by 4 publications

(8 citation statements)

References 34 publications

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“…Papanicolaou and Marshall first described urine cytology in 1945 and since then, it has acquired prime importance in the screening and follow‐up of patients with urothelial carcinoma (UC) . Urine cytology is the most specific adjunctive tool in addition to cystoscopy for the surveillance of bladder tumour .…”

Section: Introductionmentioning

confidence: 99%

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Cytohistological correlation of urine cytology in a tertiary centre with application of the Paris system

et al. 2018

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Section: Introductionmentioning

confidence: 99%

“…Urine cytology has high variability in diagnostic accuracy especially in the identification of low‐grade UC (LGUC) as reported in studies conducted worldwide …”

Section: Introductionmentioning

confidence: 99%

Cytohistological correlation of urine cytology in a tertiary centre with application of the Paris system

et al. 2018

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“…Only a few studies have previously evaluated ASC in urine cytology and found that they rarely occurred, with a reported incidence of ASC in 0.3%-0.9% of urine specimens. 1,2,5 In our study, ASC were seen in 0.15% of urine specimens; but we believe this rate under-represented the true incidence of ASC in urine cytology because ASC were not initially reported in 33 of 91 patients (36%) in our current cohort (Figure 1). A similar observation was made by others.…”

Section: Discussionmentioning

confidence: 58%

“…4 There is limited available literature on the clinical significance of ASC in urine cytology, which did not objectively evaluate the grading of ASC and/or their correlation with associated urothelial cell abnormality (UCA). 1,2,5,6 The Paris System for Reporting Urinary Cytology (TPS) only recently addressed ASC but provided no corresponding risks of HG malignancy (ROHMs). 7 The objective of the current study was to evaluate urine cytology cases with ASC, objectively grade the squamous atypia, and correlate the findings with accompanying UCA and ROHMs.…”

Section: Introductionmentioning

confidence: 99%

Atypical squamous cells in urine cytology are associated with a significant risk of high‐grade malignancy

Ho,

Elsheikh

2024

Cancer Cytopathology

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BackgroundAtypical squamous cells (ASC) in urine cytology are rarely found, and their clinical significance is not well studied. Previous studies were limited by a small number of cases and a lack of objective grading of ASC and/or their correlation with accompanying urothelial cell abnormality (UCA).MethodsThe institutional database was searched over 10 years for urine cytology reports containing ASC or from patients who had a concurrent diagnoses of high‐grade (HG) urothelial carcinoma with squamous differentiation or squamous carcinoma. ASC were defined as keratinized squamous cells and were subcategorized as reactive, koilocytosis, low‐grade (LG) atypia, and HG atypia. Correlations with age, sex, specimen type, accompanying UCA, number of ASC, and the risk of HG malignancy (ROHM) were assessed.ResultsASC were present in 0.15% of all urine specimens (123 of 81,018). Slides and clinical follow‐up were available on 91 patients (median age, 71 years). LG and HG squamous atypia had ROHMs of 70% and 92%, respectively. ASC accompanied and not accompanied by UCA had ROHMs of 37% and 94%, respectively. Most malignancies (34 of 67; 51%) showed rare ASC in urine. Reactive changes and koilocytosis had 0% ROHM.ConclusionsASC in urine cytology is a significant finding and is associated with a high ROHM. In the absence of accompanying UCA, LG squamous atypia had a lower ROHM than HG atypia. In the presence of UCA, LG and HG squamous atypia had ROHMs of over 90%. These findings suggest that ASC and their grade of atypia should be noted in the cytology report, and clinicians should be made aware of their clinical significance.

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“…e deformable particles of SQD-98 have strength and elasticity that display dual functions of expansion and compaction under the pressure difference. ese properties improve the stability of the plugging layer and produce a good sealing effect [26].…”

Section: Laboratory Evaluation Of Plugging With Lcmmentioning

confidence: 99%

Laboratory Study on a New Composite Plugging Material with High Bearing Strength and High-Temperature Resistance

Lian

Xiong

et al. 2019

Journal of Chemistry

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The reservoir in the Central Tarim Basin is a typical high-pressure fracture-vuggy carbonate reservoir with high temperatures, which easily leads to drilling fluid losses and the high-temperature carbonate. The conventional lost circulation materials (LCMs) cannot meet the reservoir. To resolve this problem, a rigid particle with high-temperature resistance, high acid solubility, and high rigidity was developed, tested, and evaluated. According to bridge rules of 1/2–2/3 opening degree of formation fracture, the formulation experiments of GZD and other lost circulation materials were conducted and a novel composite lost circulation material (LCM) was completed. Lastly, we investigated the compatibility of LCM and mud in site though compatibility experiment, analyzed the plugging effect of the system for fracture and vuggy by laboratory static lost circulation simulation and evaluation and sand-bed plugging experiments, respectively. The results show that compared with the conventional rigid lost material, the value of high-temperature resistance is more and acid solubility is over 98%. Also, it can work well with other fiber materials (E), variable filling particles (F and G), and superfine filling particles (H) and form a novel plugging material, named MGY-I, whose temperature resistance value is more than 473.15 K, the bearing strength is over than 9 MPa, the mud filtrate invasion depth of sand bed made from coarse particles (10∼20 mesh) is only 3.0 cm within 30 minutes, and the invasion depth is less than 1 cm within 30 minutes when the sand bed is made from 80∼100 mesh. The optimal concentrations of rigid granule, lignin fiber, elastic particle, and superfine calcium carbonate are 8% (A : B : CD = 2 : 1 : 1), 0.5%, 6%, and 1%, respectively. And, the plugging function of “GZD-rigidity bridge and filling, fiber network and deformable filing” is better exerted on the formation fracture with a high loading capacity and a high-temperature resistance.

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Dysplastic Squamous Cells Are Frequently Present in Urine Cytology Specimens of Patients with High-Grade Urothelial Carcinoma

Cited by 4 publications

References 34 publications

Cytohistological correlation of urine cytology in a tertiary centre with application of the Paris system

Cytohistological correlation of urine cytology in a tertiary centre with application of the Paris system

Atypical squamous cells in urine cytology are associated with a significant risk of high‐grade malignancy

Laboratory Study on a New Composite Plugging Material with High Bearing Strength and High-Temperature Resistance

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