Dysplasias of Cerebral Vasculature

Friede, Reinhard L.

doi:10.1007/978-3-7091-3338-5_34

Cited by 3 publications

(5 citation statements)

References 31 publications

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“…This should be regarded as a persistent fetal meningeal vascularization, a developmental trait, which is seen often in dysraphic or dysplastic cerebral malformations (Friede 1975). It may indicate a developmental disturbance in early embryogenesis, although it is not a very reliable index for the exact dating oflesions (Friede 1975). The perivascular mineral deposits and cortical incTUsted neurons, seen in Case 1, appear to be a nonspecific phenomenon, although this pattern of mineralization is unusual.…”

Section: Discussionmentioning

confidence: 96%

“…intrauterine growth retardation and webbing may be secondary to a lack of fetal movernent (Hall et In the present study the leptomeningeal angiomatosis (Cases land 4) is a remarkable, not previously described cerebral finding. This should be regarded as a persistent fetal meningeal vascularization, a developmental trait, which is seen often in dysraphic or dysplastic cerebral malformations (Friede 1975). It may indicate a developmental disturbance in early embryogenesis, although it is not a very reliable index for the exact dating oflesions (Friede 1975).…”

Section: Discussionmentioning

confidence: 99%

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The Heterogeneity of the Pena-Shokeir Syndrome

Hageman¹,

Willemse²,

Ketel³

et al. 1987

Neuropediatrics

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There is evidence that the Pena-Shokeir syndrome is not a specific phenotype but should be regarded as a "fetal akinesia deformation sequence". A neuropathological study of six random new cases was performed to evaluate this theory. Brain pathology observed included persistent fetal meningeal vascularization (two cases), agenesis of the septum pellucidum (one case) and hydranencephaly (one case). Investigation of the spinal cord (in two cases) revealed no abnormalities. Muscle histology (in four cases) was indicative of neurogenic atrophy in two cases. These findings are compared with the data of the 28 cases previously described. It is concluded that the Pena-Shokeir syndrome is a heterogeneous syndrome in which cerebral lesions may play an important role in the pathogenesis. The cerebral malformations may also indicate the time of origin and contribute in the perinatal death of this syndrome.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

The Heterogeneity of the Pena-Shokeir Syndrome

Hageman¹,

Willemse²,

Ketel³

et al. 1987

Neuropediatrics

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“…There are at least three possibilities. The simplest (Bielschowsky 1923, Crome 1956, Friede 1989) is that some injuring event (e.g. hypoxia, ischaemia) takes place around 335 the 16th week of gestation, destroys the radial glial fibres, and simply arrests migration thereafter.…”

Section: Discussionmentioning

confidence: 99%

“…

Clinical and neurogenetic understanding of diffuse neuronal migration disorders (NMDS) has been greatly helped by the development of high-resolution M R I , which permits diagnosis of these entities during life (Barkovich et a/. 1987, 1989; Byrd et al. 1989; Marchal et a(.

…”

mentioning

confidence: 99%

“…. On the basis of anatomopat hological findings, classical neuropathologists suggested many decades ago that lissencephaly, diffuse pachygyria and generalized laminar heterotopia may represent variations in severity of the same process (Bielschowsky 1923, Crome 1956, Friede 1989. The lissencephalies are situated at one end of the spectrum (Dobyns 1989, Dobyns and Ledbetter 1990, Aicardi 1991, Barkovich et al 1991) and the periventricular nodular heterotopias at the other.…”

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confidence: 99%

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Stages and Patterns of Centrifugal Arrest of Diffuse Neuronal Migration Disorders

Palmini

Andermann

Grissac³

et al. 1993

Develop Med Child Neuro

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SUMMARY Centrifugal migration of newly generated neuroblasts toward the cortical surface can be arrested at different levels, resulting in anatomically different disorders. This is illustrated by three patients with diffuse or generalized neuronal migration disorders (NivlDs): pachygyria, subcortical laminar heterotopia ('double‐cortex' syndrome), and periventricular laminar heterotopia. All had medically intractable partial and generalized epileptic seizures, but there was no close correlation between the type of dysplasia and intelligence or clinical pattern. The low intelligence found in these patienrs may relate to the epileptic syndrome, rather than to the NMDs alone. MRI suggested that in this spectrum of disorders the migration process was arrested at different stages, depending on the extent, timing and site of damage to radial glial fibres. RÉSUMÉ Etapes et groupements des arréts centrifuges dans les troubles de la migration neuronale La migration centrifuge des neuroblastes nouvellement formes peut etre arrétee a differents niveaux, provoquant des anomalies anatomiques différentes. Cela est bien illustré chez trois patients presentant des troubles diffus ou généralisés de la migration neuronale (NMD): pachygyrie. heterotopie laminaire sous‐corticale (syndrome du double cortex) et heterotopie laminaire périventriculaire. Tous présentaient des crises épileptiques partielles et généralisées résistant au traitement medical, mais il n'y avait pas de forte corrélation entre le type de dysplasie et l'intelligence ou l'allure clinique. La faible intelligence observee chez ces patients peut etre reliée au syndrome épileptique plutot qu'a la seule NMD. L'IRM suggérait que dans ce spectre de troubles, le processus migratoire s'etait arréte a differentes étapes, dependant de l'etendue, du moment et du asiege de la lesion des fibres gliales radiées. ZUSAMMENFASSUNG Stadien und Muster der zentrifugalen Hemmung bei diffusen neuronalen Migrationssrorungen Zentrifugale Migration von neu gebildeten Neuroblasten zur cortikalen Oberflache kann an verschiedenen Stellen gestoppt werden. was zu unterschiedlichen anatomischen Storungen fuhrt. Dies wird an drei Patienten mit diffusen oder generalisierten neuronalen Migrationsstorungen (NMD) gezeigt: Pachygyrie, subcorticale laminare Heterotopie (‘double cortex’ Syndrom) und periventrikulare laminare Heterotopie. Alle hatten medikamentos nicht beherrschbare partielle oder generalisierte epileptische Anfalle, aber es fand sich keine direkte Korrelation zwischen der Art der Dysplasie und der lntelligenz oder dem klinischen Bild. Die geringe lntelligenz dieser Patienten hangt moglicherweise eher mit dem epileptischen Syndrom zusammen als mit den NMD allein. MRI Befunde lassen vermuten, daB bei diesem Spektrum der Storungen der Migrationsprozess in verschieden Stadien gestoppt wurde, je nach Ausdehnung, Zeitpunkt und Lokalisation der Schadigung der Gliafasern. RESUMEN Estadios y patrones en la detencion centrifuga en las alteraciones de la ernigracion neuronal difusa La emigracion c...

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Perinidal Dilated Capillary Networks in Cerebral Arteriovenous Malformations

et al. 2004

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Without exception, each nidus was accompanied by a PDCN, which connected not only to the nidus, feeding arteries, and draining veins, via arterioles and venules, but also to normal capillaries, arterioles, and venules. The PDCN should be considered in studies aimed at gaining an understanding of the mechanisms underlying the intraoperative and postoperative bleeding, growth, and recurrence of surgically treated cerebral arteriovenous malformations.

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Dysplasias of Cerebral Vasculature

Cited by 3 publications

References 31 publications

The Heterogeneity of the Pena-Shokeir Syndrome

The Heterogeneity of the Pena-Shokeir Syndrome

Stages and Patterns of Centrifugal Arrest of Diffuse Neuronal Migration Disorders

Perinidal Dilated Capillary Networks in Cerebral Arteriovenous Malformations

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