Dysphagia severity is associated with worse sleep-disordered breathing in infants with Down syndrome

Cho, Yeilim; Kwon, Younghoon; DelRosso, Lourdes M.; Sobremonte-King, Michelle

doi:10.5664/jcsm.10446

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Previous work published by our group showed that in infants with DS, dysphagia was correlated with the severity of OSA [ 32 ]. However, comorbidities did not appear to influence the presence or severity of OSA in the 2–4 year age group in this study.…”

Section: Discussionmentioning

confidence: 99%

Sleep-Disordered Breathing and Associated Comorbidities among Preschool-Aged Children with Down Syndrome

Kolstad,

DelRosso,

Tablizo

et al. 2024

Children

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Children with Down syndrome (DS) are at high risk of sleep-disordered breathing (SDB). The American Academy of Pediatrics recommends a polysomnogram (PSG) in children with DS prior to the age of 4. This retrospective study examined the frequency of SDB, gas exchange abnormalities, co-morbidities, and surgical management in children with DS aged 2–4 years old at Seattle Children’s Hospital from 2015–2021. A total of 153 children underwent PSG, with 75 meeting the inclusion criteria. The mean age was 3.03 years (SD 0.805), 56% were male, and 54.7% were Caucasian. Comorbidities included (n, %): cardiac (43, 57.3%), dysphagia or aspiration (24, 32.0%), prematurity (17, 22.7%), pulmonary (16, 21.3%), immune dysfunction (2, 2.7%), and hypothyroidism (23, 30.7%). PSG parameter data collected included (mean, SD): obstructive AHI (7.9, 9.4) and central AHI (2.4, 2.4). In total, 94.7% met the criteria for pediatric OSA, 9.5% met the criteria for central apnea, and 9.5% met the criteria for hypoventilation. Only one child met the criteria for hypoxemia. Overall, 60% had surgical intervention, with 88.9% of these being adenotonsillectomy. There was no statistically significant difference in the frequency of OSA at different ages. Children aged 2–4 years with DS have a high frequency of OSA. The most commonly encountered co-morbidities were cardiac and swallowing dysfunction. Among those with OSA, more than half underwent surgical intervention, with improvements in their obstructive apnea hypopnea index, total apnea hypopnea index, oxygen saturation nadir, oxygen desaturation index, total arousal index, and total sleep duration. This highlights the importance of early diagnosis and appropriate treatment. Our study also suggests that adenotonsillar hypertrophy is still a large contributor to upper airway obstruction in this age group.

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Section: Discussionmentioning

confidence: 99%