Dysphagia in Inclusion Body Myositis

Oh, Terry H.; Brumfield, Kathlyn A.; Hoskin, Tanya L.; Kasperbauer, Jan L.; Basford, Jeffrey R.

doi:10.1097/phm.0b013e31818a50e2

Cited by 96 publications

(76 citation statements)

References 27 publications

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“…As with AD, sIBM is by consensus a combination of muscular degeneration and inflammation [8], often characterized by slow-onset atrophy, lethargy, and dysphagia, with hallmark biomarkers of filamentous inclusions and intracellular Aβ deposits in muscle cells [9]. As with AD, sIBM is late-onset, with the highest prevalence occurring in older age groups, especially beginning at the age of 50 [8,10]. Thus, it is seen that both degenerative diseases contribute to lessening the quality of life of the elderly, aggravated by the lack of a known cure.…”

Section: Introductionmentioning

confidence: 99%

Coconut (Cocos nucifera) Ethanolic Leaf Extract Reduces Amyloid-β (1-42) Aggregation and Paralysis Prevalence in Transgenic Caenorhabditis elegans Independently of Free Radical Scavenging and Acetylcholinesterase Inhibition

Manalo

Silvestre²,

Barbosa³

et al. 2017

Biomedicines

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Virgin coconut oil (VCO) has been the subject of several studies which have aimed to alleviate Alzheimer’s disease (AD) pathology, focusing on in vitro antioxidant and acetylcholinesterase (AChE) inhibitory activities. Here, we studied an underutilized and lesser-valued part of the coconut tree, specifically the leaves, using in vitro and in vivo approaches. Coconut leaf extract (CLE) was screened for antioxidant and AChE inhibitory properties in vitro and therapeutic effects in two strains of transgenic Caenorhabditis elegans expressing amyloid-β1–42 (Aβ1-42) in muscle cells. CLE demonstrated free radical scavenging activity with an EC50 that is 79-fold less compared to ascorbic acid, and an AChE inhibitory activity that is 131-fold less compared to Rivastigmine. Surprisingly, in spite of its low antioxidant activity and AChE inhibition, CLE reduced Aβ deposits by 30.31% in CL2006 in a dose-independent manner, and reduced the percentage of paralyzed nematodes at the lowest concentration of CLE (159.38 μg/mL), compared to dH2O/vehicle (control). Phytochemical analysis detected glycosides, anthocyanins, and hydrolyzable tannins in CLE, some of which are known to be anti-amyloidogenic. Taken together, these findings suggest that CLE metabolites alternatively decrease AB1–42 aggregation and paralysis prevalence independently of free radical scavenging and AChE inhibition, and this warrants further investigation on the bioactive compounds of CLE.

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Section: Introductionmentioning

confidence: 99%

Coconut (Cocos nucifera) Ethanolic Leaf Extract Reduces Amyloid-β (1-42) Aggregation and Paralysis Prevalence in Transgenic Caenorhabditis elegans Independently of Free Radical Scavenging and Acetylcholinesterase Inhibition

Manalo

Silvestre²,

Barbosa³

et al. 2017

Biomedicines

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“…The Mendelsohn Maneuver, or voluntary prolongation of hyolaryngeal elevation at the peak of the swallow, has been used to treat patients with pharyngeal dysphagia for many years 1–3 --sometimes as a compensatory strategy to help the bolus pass more efficiently through the pharynx 4–6 and sometimes as part of a rehabilitative exercise program 7–10 . Early reports on the Mendelsohn maneuver suggested use of the maneuver increases laryngeal elevation and maximal hyoid superior displacement and provides an immediate effect in prolonging the duration of opening of the upper esophageal sphincter (UES) but not the diameter 1–6 .…”

Section: Introductionmentioning

confidence: 99%

Effects of Mendelsohn Maneuver on Measures of Swallowing Duration Post Stroke

McCullough¹,

Kamarunas²,

Mann³

et al. 2012

Topics in Stroke Rehabilitation

113

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“…In the present study, no significant difference was found on Schüle's SPRS, Fink Although the patients' life expectancy was not investigated using suitable methods, it does not seem to decrease, since six participants were 60 years old or older, and one was 81 years old. Regarding causes of death, no repeated respiratory problems (pneumonia) were detected, as in other studies on rare genetic diseases [16], [17]. Therefore, Spoan syndrome is different from conditions such as Duchenne muscular dystrophy, in which the life expectancy is limited to two or three decades as a function of cardiac and respiratory involvement [18], and amyotrophic lateral sclerosis, with a life expectancy of two to five years after diagnosis [19], [20].…”

Section: Discussionmentioning

confidence: 63%

Motor impairment in a rare form of spastic paraplegia (Spoan syndrome): a 10-year follow-up

Galvão

Cavalcante

Olinda

et al. 2019

Preprint

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Background: Spastic paraplegia, optic atrophy and neuropathy (Spoan syndrome) is an autosomal recessive disease with approximately 70 cases recorded in Brazil and Egypt. Methods: This is a prospective longitudinal study performed with 47 patients affected with Spoan syndrome of seven communities of Rio Grande do Norte (Brazil) to investigate changes in motor function based on comparative data obtained from a 10-year follow-up. Results: The mean age of the participants was 47.21±12.42 years old, and the mean age at loss of ambulation and hand function were 10.78±5.55 and 33.58±17.47 years old, respectively. Spearman’s correlation analysis between the score on the Modified Barthel Index and the investigated variables evidenced statistical significance for age (p<0.001) and right- and left-hand grip strength (p=0.042 and p=0.021, respectively). Statistical significance was not evidenced for the remainder of the variables, including age at onset of symptoms (p=0.634), age at loss of ambulation (p=0.664) and age at loss of hand function (p=0.118). Conclusions: Our analysis allows asserting that the participants exhibited slight dependence until age 35. The greatest losses occurred from ages 35 to 41, and starting at 50, practically all patients become completely dependent. These findings are relevant for determining the prognosis as well as suitable treatment, rehabilitation and assistive technology for these individuals.

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Dysphagia in Inclusion Body Myositis

Abstract: Dysphagia is a progressive condition in patients with inclusion body myositis and often leads to death from aspiration pneumonia. Treatment targeting cricopharyngeal muscle dysfunction, such as the Mendelsohn maneuver, will benefit from further investigation.

Cited by 96 publications

References 27 publications

Coconut (Cocos nucifera) Ethanolic Leaf Extract Reduces Amyloid-β (1-42) Aggregation and Paralysis Prevalence in Transgenic Caenorhabditis elegans Independently of Free Radical Scavenging and Acetylcholinesterase Inhibition

Coconut (Cocos nucifera) Ethanolic Leaf Extract Reduces Amyloid-β (1-42) Aggregation and Paralysis Prevalence in Transgenic Caenorhabditis elegans Independently of Free Radical Scavenging and Acetylcholinesterase Inhibition

Effects of Mendelsohn Maneuver on Measures of Swallowing Duration Post Stroke

Motor impairment in a rare form of spastic paraplegia (Spoan syndrome): a 10-year follow-up

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