Dyspeptic symptoms and water load test in patients with functional dyspepsia and reflux disease

Chen, C. L.; Lin, Hans Hsienhong; Chen, M. C.; Huang, Liwen

doi:10.1080/00365520410009483

Cited by 32 publications

(40 citation statements)

References 9 publications

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“…The WLT is a tool that was developed as a noninvasive method to assess gastric function, including fundic accommodation and visceral hypersensitivity, and has been used in patients with FD [17][18][19][20], GERD [21], and bulimia nervosa [25]. This test is easily performed, well tolerated, and reproducible in healthy adults [26].…”

Section: Discussionmentioning

confidence: 99%

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Drinking Capacity and Severity of Dyspeptic Symptoms During a Water Load Test After Nissen Fundoplication

et al. 2007

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Up to 30% of subjects undergoing Nissen fundoplication develop dyspeptic symptoms. Previous studies using the water load test have shown that functional dyspepsia patients have a diminished drinking capacity due to increased visceral sensitivity. Here we investigate drinking capacity and severity of symptoms in 9 patients with dyspeptic symptoms after fundoplication, 9 patients without symptoms after surgery, 18 functional dyspepsia patients, and 18 controls. The water load test was performed by having subjects drinking room-temperature tap water at a predetermined rate of 15 ml/min. The presence and severity of symptoms during the test were evaluated every 5 min using a Likert scale. We found that patients with dyspeptic symptoms after fundoplication had a significantly lower drinking capacity and higher symptoms scores than controls (P<0.05) but values similar to those of functional dyspepsia patients (P>0.05). In contrast, drinking capacity in patients without symptoms after surgery was similar to that in controls (P>0.05). These findings suggest that, as in functional dyspepsia, severe dyspeptic symptoms after Nissen fundoplication are associated with an impaired drinking capacity, reflecting visceral hypersensitivity or impaired gastric accommodation or both.

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Section: Discussionmentioning

confidence: 99%

“…Recently, drinking load tests with water or a liquid meal have been used to discriminate functional dyspepsia (FD) and GERD patients from normal subjects [17][18][19][20][21][22]. In previous studies a significant correlation between the water load test (WLT) and the nutritional beverage test (Nutridrink test) has been found [17,18].…”

Section: Introductionmentioning

confidence: 96%

Drinking Capacity and Severity of Dyspeptic Symptoms During a Water Load Test After Nissen Fundoplication

et al. 2007

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“…A number of recent studies compared drinking capacity in FD patients to that of control subjects [25][26][27][28], but the underlying mechanisms remain unclear. Jones et al [26] found that the maximum tolerated water load volume discriminates better between health and FD than symptoms provoked during the water load test.…”

Section: Role Of Motility Disordersmentioning

confidence: 98%

Pathogenesis and therapy for idiopathic dyspepsia

Tack

Kindt

2005

Curr Gastroenterol Rep

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Functional dyspepsia (FD) is one of the most common gastrointestinal disorders. This review summarizes recent progress in our understanding of the pathogenesis and therapy for FD. Although distinction among FD, irritable bowel syndrome, and reflux disease is difficult in population-based studies, separate entities can be recognized in patients who seek medical attention. The pathogenesis of FD remains unclear, but recent studies have demonstrated a role for acute gastrointestinal infection in triggering FD and in genetic polymorphisms of G-proteins in predisposing to FD. The role of abnormalities in gastric motor function, visceral hypersensitivity, and psychosocial factors in the pathophysiology of dyspeptic symptoms has been the topic of multiple studies. Treatment options for FD remain limited. Recent studies have focused on acid-suppressive drugs and on novel prokinetics. Progress in our understanding of the pathogenesis and pathophysiology of FD may lead to new or improved treatment modalities. Areas of major advances are the role of infection and genetic predisposition and studies on the role of abnormalities in gastric motility and sensitivity.

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“…The patients were questioned with regard to the presence and severity of nausea, vomiting, heartburn, belching, satiety, fullness, and bloating at the beginning of the study (Chen et al, 2005). The symptoms were scored using a 10-point scale from 0 when the symptom was absent to 9 when the symptom was worst.…”

Section: Symptomatic Assessmentsmentioning

confidence: 99%

Clinical utility of electrogastrography and the water load test in patients with upper gastrointestinal symptoms

Chen

Lin

et al. 2006

J. Smooth Muscle Res.

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We assessed gastric myoelectric functioning in patients with various gastrointestinal symptoms and to determine the utility of electrogastrography in differentiating specific disease entities. Electrogastrography with a water load was performed in 101 patients with reflux disease, 55 patients with active gastric ulcer, 59 patients with functional dyspepsia, and 30 controls. Upper gastrointestinal symptoms were assessed in each patient. Electrogastrography was abnormal in 41 (40.6%) patients with reflux disease, 31 (56.4%) patients with active gastric ulcer, and 26 (44.1%) patients with functional dyspepsia (P=NS). Water load tolerance was greater in controls than any patient group (all P<0.05). Symptoms predicted abnormal electrogastrography in reflux patents with satiety (OR=2.9; P<0.05) and in dyspeptic patients with nausea (OR=3.1; P<0.05). Although electrogastrography is helpful in differentiating subgroups of patients with nausea or satiety, it cannot directly differentiate disease states such as reflux disease, gastric ulcer, and functional dyspepsia.

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Dyspeptic symptoms and water load test in patients with functional dyspepsia and reflux disease

Abstract: Both FD and GERD subjects have altered perception to gastric fullness induced by the WLT compared to healthy controls. Good correlations have been observed between the WLT and dyspeptic symptoms such as early satiety and postprandial fullness, but not in GERD.

Cited by 32 publications

References 9 publications

Drinking Capacity and Severity of Dyspeptic Symptoms During a Water Load Test After Nissen Fundoplication

Drinking Capacity and Severity of Dyspeptic Symptoms During a Water Load Test After Nissen Fundoplication

Pathogenesis and therapy for idiopathic dyspepsia

Clinical utility of electrogastrography and the water load test in patients with upper gastrointestinal symptoms

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