Dyspareunia and lubrication in premature ovarian failure using hormonal therapy and vaginal health

“…Infertility cannot be resolved by in-vitro fertilization (IVF) except by receiving donation cycles of oocyte/embryo [18, 19]. Secondly, women with POI showed worse sexual performance, which could not be resolved by hormonal therapy that was accompanied by increased pain and poorer lubrication than the women with normal gonadal function in the control group [20]. Thirdly, the females with early onset of menopause and premature ovarian failure present a lower value of bone mineral density (BMD) in both femoral neck and lumbar vertebrae [21–26], increasing the bone fragility and risk of fracture than the normal women.…”

Section: Introductionmentioning

confidence: 99%

Role of microRNAs in premature ovarian insufficiency

Guo

Sun

Lai

2017

Reprod Biol Endocrinol

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Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follicle-stimulating hormone (FSH) in women <40-year-old, primarily originating from iatrogenic factors, karyotypic abnormalities, and genetic factors. However, the etiology of POI remains unknown in approximately 90% of cases. POI could lead to infertility, osteoporosis, cardiovascular disorder, and cognitive dysfunction. MicroRNAs (miRNAs) are a class of endogenous noncoding RNAs (ncRNAs) that can mediate post-translational silencing of the genes involved in the regulation of proliferation, differentiation, apoptosis, development, tumorigenesis, and hematopoiesis. Recently, the regulatory functions of miRNAs in the development of POI have been the topic of intensive research. The present review addresses the association of miRNAs’ machinery genes (Dicer, Drosha, and XPO5) with POI and the miRNA expression profiles in the plasma of patients with POI. In addition, several specific miRNAs (miR-23a, miR-27a, miR-22-3p, miR-146a, miR-196a, miR-290-295, miR-423, and miR-608) related to POI are also examined in order to highlight the issues that deserve further investigation. A thorough understanding of the exact regulatory roles of miRNAs is imperative to gain novel insights into the etiology of idiopathic POI and offer new research directions in the field.

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“…We found the vaginal microbiota to be increasingly diverse with increased species richness in the case of POF, and a significant shift in overall microbial diversity was observed. However, a previous cross-sectional study of microbiota failed to identify obvious differences between individuals in terms of vaginal microbiota diversity [28,29]. The strength of our study lies in the comprehensive description of microbial communities associated with POF achieved through the use of 16S rRNA sequencing; particularly, the association with clinical characteristics of POF; and the utilisation of predictive models to identify bacterial taxa that are differentially expressed in POF.…”

Section: Discussionmentioning

confidence: 86%

Changes in the vaginal microbiota associated with primary ovarian failure

Wang

Han

et al. 2020

Preprint

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BackgroundPrimary ovary failure (POF) is defined as follicular failure in women of reproductive age. Although many factors are speculated to contribute to the occurrence of POF, the exact aetiology is unclear.Alterations in the microbiome of women with POF are poorly studied; MethodsThis study investigated the vaginal microbiota of 22 patients with POF and 29 healthy individuals.High-throughput Illumina Miseq sequencing targeting the V3-V4 region of the 16S ribosomal RNA (rRNA) gene was used to evaluate the relationships between vaginal flora and clinical characteristics of POF. ResultsDifferent from before, we found the diversity and richness of the vaginal flora of patients with POF was significantly different to that of healthy controls. Comparison of the flora of patients POF with that of menopausal women revealed that the relative abundance of Lactobacillus was significantly reduced in the latter, and women with reduced relative abundance of Lactobacillus in microbiota community decreased the pregnancy success rate at term. This study confirms that vaginal microbiota dysbiosis occurs in patients with POF. Additionally, the vaginal microbiota is closely related to clinical characteristics of POF and the inclusion of a disease verification model could reveal more accurate information related to the composition of the microbiota and its functions. ConclusionThe result suggests the present study enabled identification of microbiota associated with POF, further investigations of differences in the microbiota in the context of POF will improve our understanding of the pathogenesis of the disease which involve modification of the vaginal microbiota.

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Dyspareunia and lubrication in premature ovarian failure using hormonal therapy and vaginal health

Abstract: These findings suggest that the use of systemic estrogen among women with POF is not enough to improve complaints of lubrication and pain despite conferring similar tropism and vaginal flora. Other therapeutic options need to be evaluated.

Cited by 43 publications

References 27 publications

ESHRE Guideline: management of women with premature ovarian insufficiency

ESHRE Guideline: management of women with premature ovarian insufficiency

Role of microRNAs in premature ovarian insufficiency

Changes in the vaginal microbiota associated with primary ovarian failure

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