Dysmenorrhoea

Kolhe, Shilpa; Deb, Shilpa

doi:10.1016/j.ogrm.2011.09.006

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…[12] Similar to various other studies, majority reported missing school/work, implicating a negative impact on quality of life with substantial social, economical, and educational consequences. [13] Fifty three percent respondents used non-pharmacological measures such as acupressure, massage, topical heat/cooling therapy, exercises which are found to be generally less effective and often harmful. [91415] In majority of women (51%), self-medication was initiated by self/relatives, akin to previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…[11] Mefenamic acid, a NSAID, relieves PD primarily by suppressing endometrial prostaglandin (PG) production, thus alleviating cramps and restoring normal uterine activity. [13] It is also found to decrease the volume of menstrual flow and relieve PG-induced symptoms like headache, bloating, diarrhea, and breast tenderness. [1819] In addition, it is also reported to have direct analgesic action on Central Nervous System (CNS) mediated by interactions with descending serotonergic pathways, together with modulation of neurotransmission at glycine or N-methyl-D-aspartate receptors independent of cyclo-oxygenase inhibition.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the pattern, efficacy, and tolerability of self-medicated drugs in primary dysmenorrhea: A questionnaire based survey

Sugumar

Krishnaiah

Channaveera³

et al. 2013

Indian J Pharmacol

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Objective:To compare the pattern, efficacy, and tolerability of self-medicated drugs and to assess the adequacy of their dose in primary dysmenorrhea (PD).Materials and Methods:A survey using a self-developed, validated, objective, and structured questionnaire as a tool was conducted among subjects with PD. Statistical analysis was carried out using Chi-square test and ANOVA with post-hoc Tuckey's test.Results:Out of 641 respondents, 42% were self-medicated. The pattern of drugs used was: Dicyclomine, an unknown drug, mefenamic acid, mefenamic acid + dicyclomine, and metamizole by 35%, 29%, 26%, 9%, and 1% of respondents, respectively. Mefenamic acid + dicyclomine, the combination was the most efficacious in comparison to other drugs in moderate to severe dysmenorrhea. There was better tolerability with mefenamic acid + dicyclomine group compared to other drugs. Sub-therapeutic doses were used by 86% of self-medicating respondents.Conclusions:The prevailing self-medication practices were inappropriate in a substantial proportion of women with inadequate knowledge regarding appropriate drug choice, therapeutic doses, and their associated side effects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of the pattern, efficacy, and tolerability of self-medicated drugs in primary dysmenorrhea: A questionnaire based survey

Sugumar

Krishnaiah

Channaveera³

et al. 2013

Indian J Pharmacol

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“…1 It is the most common problem in adolescent females and young adult females affecting their daily routine activities. 2 Dysmenorrhoea is responsible for significant absenteeism from college and affects the students' social activities due to mood disturbance.…”

Section: Introductionmentioning

confidence: 99%

Comparison of self-medication practice for dysmenorrhoea in medical, nursing and dental students

Jayanthi

Anuradha

2016

Int J Basic Clin Pharmacol

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“…Dysmenorrhea is the best-studied uterine pain syndrome. Primary dysmenorrhea is treated with simple analgesics, usually naproxen, while secondary dysmenorrhea treatment relies on removal of the underlying cause of the pain ( Kohle and Deb, 2011 ). As other pelvic organs can cause pelvic pain a thorough investigation is important.…”

Section: Current Therapies For Frt Painmentioning

confidence: 99%

Female reproductive tract pain: targets, challenges, and outcomes

2014

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Pain from the female reproductive tract (FRT) is a significant clinical problem for which there are few effective therapies. The complex neuroanatomy of pelvic organs not only makes diagnosis of pelvic pain disorders difficult but represents a challenge to development of targeted therapies. A number of potential therapeutic targets have been identified on sensory neurons supplying the FRT but our knowledge on the basic neurophysiology of these neurons is limited compared with other viscera. Until this is addressed we can only guess if the new experimental therapies proposed for somatic, gastrointestinal, or bladder pain will translate to the FRT. Once suitable therapeutic targets become clear, the next challenge is drug delivery. The FRT represents a promising system for topical drug delivery that could be tailored to act locally or systemically depending on formulation. Development of these therapies and their delivery systems will need to be done in concert with more robust in vivo and in vitro models of FRT pain.

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Dysmenorrhoea

Cited by 4 publications

References 9 publications

Comparison of the pattern, efficacy, and tolerability of self-medicated drugs in primary dysmenorrhea: A questionnaire based survey

Comparison of the pattern, efficacy, and tolerability of self-medicated drugs in primary dysmenorrhea: A questionnaire based survey

Comparison of self-medication practice for dysmenorrhoea in medical, nursing and dental students

Female reproductive tract pain: targets, challenges, and outcomes

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