Dyslipidemia in South Asians living in a western community

Kolluri, Raghu; Pinedo, Daryl; Edmondson-Holt, Ardis; Grewal, Kanny; Falko, James M.

doi:10.1016/j.jacl.2008.12.002

Cited by 12 publications

(13 citation statements)

References 45 publications

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“…Differences in triglycerides and HDL-cholesterol between South Asian men and women have also been documented [38], with higher CHD risk for South Asian men as compared to African-Caribbean, white Europeans, and African and Hispanic Americans [39, 40]. The increased predisposition of South Asians to age-related chronic diseases is attributed not only to genetic susceptibility, but also to differences in fat deposition, high physical inactivity and differences in diet [40–42].…”

Section: Discussionmentioning

confidence: 99%

Telomere Length Attrition, a Marker of Biological Senescence, Is Inversely Correlated with Triglycerides and Cholesterol in South Asian Males with Type 2 Diabetes Mellitus

Harte

Silva

Miller

et al. 2012

Experimental Diabetes Research

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South Asians have a higher risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) than white Caucasians, for a given BMI. Premature biological ageing, assessed by reduction in telomere length (TL), may be mediated by factors resulting from altered metabolic profiles associated with obesity. We hypothesise that ethnicity and metabolic status represent detrimental factors contributing to premature biological ageing. Therefore we assessed TL in two South Asian, age and BMI-matched cohorts [T2DM (n = 142) versus non-T2DM (n = 76)] to determine the effects of BMI, gender, lipid and CVD profile on biological ageing. Genomic DNA was obtained from the UKADS cohort; biochemical and anthropometric data was collected and TL was measured by quantitative real-time PCR. Our findings indicated a gender-specific effect with reduced TL in T2DM men compared with non-T2DM men (P = 0.006). Additionally, in T2DM men, TL was inversely correlated with triglycerides and total cholesterol (r = −0.419, P < 0.01; r = −0.443, P < 0.01). In summary, TL was reduced amongst South Asian T2DM men and correlated with triglycerides and total cholesterol. This study highlights enhanced biological ageing among South Asian, T2DM men, which appears to be tracked by changes in lipids and BMI, suggesting that raised lipids and BMI may directly contribute to premature ageing.

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Section: Discussionmentioning

confidence: 99%

Telomere Length Attrition, a Marker of Biological Senescence, Is Inversely Correlated with Triglycerides and Cholesterol in South Asian Males with Type 2 Diabetes Mellitus

Harte

Silva

Miller

et al. 2012

Experimental Diabetes Research

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“…21,80 Although SA have similar levels of LDL cholesterol compared to Europids, they have significantly lower levels of HDL cholesterol. [81][82][83] This may imply a genetic predisposition to low HDL cholesterol acquired through increased propensity to develop visceral adiposity and liver fat with associated dysregulation in key enzymes such as cholesteryl ester transfer protein. 84 .…”

Section: Dyslipidemiamentioning

confidence: 99%

Cardiovascular Disease in South Asian Migrants

Fernando¹,

Razak²,

Lear³

et al. 2015

Canadian Journal of Cardiology

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“…119 Moreover, there is an increasing prevalence of CHD in the South Asian population, in migrant Indians as well as native Indians, and this ethnic group is in the middle of a rising epidemic not seen in other ethnic groups. 117,120,121 Traditional risk factors including hypertension, total cholesterol, and LDL-C are highly prevalent in South Asians. [122][123][124] Furthermore, type 2 diabetes is highly prevalent and central obesity is also on the rise in South Asians.…”

Section: Metabolic Syndromementioning

confidence: 99%

“…50,119,125 Since central obesity is an important component of metabolic syndrome, it may be an important factor in the development of CHD in South Asians. 117 Although traditional risk factors are largely responsible for the prevalence of CHD in South Asians, tobacco consumption and diabetes are increasing in this population, which are also contributory factors. 117,125 Additionally, novel factors such as highsensitivity C-reactive protein (hs-CRP), lipoprotein (Lp)-(a), and small, dense LDL are also prevalent in South Asians.…”

Section: Metabolic Syndromementioning

confidence: 99%

Balancing Efficacy and Tolerability Issues with Statin Therapy— Considerations for the Use of Pitavastatin in Special Patient Populations

Falko¹

2011

US Endocrinology

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One of the main objectives of cardiovascular care is to control elevated low-density lipoprotein cholesterol (LDL-C). Statins are the mainstay for managing LDL-C with proven high efficacy and satisfactory safety profiles. However, the most known side effects are muscle symptoms, which are particularly common in individuals who often have co-existing conditions and are taking multiple medications. The latest statin that has become available, pitavastatin, is not known to cause cytochrome P450-mediated drug–drug interactions, making it an ideal statin for individuals at a high risk for side effects. Pitavastatin will be particularly beneficial in treating patients with mixed dyslipidemia, as it is effective in reducing triglycerides and increasing high-density lipoprotein cholesterol (HDL-C). Pitavastatin has an established history of use, and has a safety and adverse event profile similar to that of other existing statins. Individuals at high risk from side effects with statins include older people (>65 years), individuals with diabetes, kidney disease, or metabolic syndrome and individuals taking multiple medications. South Asian populations that have migrated to Western countries are at particularly high risk for cardiovascular disease, and this population also has an increased risk for statin-related side effects. This article will summarize the factors that place individuals at high risk for dyslipidemia, treatment of high risk populations with statins, and the issues associated with treating high risk populations with statins. The benefits of treating these individuals with pitavastatin will be reviewed, as well as alternative forms of therapy.

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Dyslipidemia in South Asians living in a western community

Cited by 12 publications

References 45 publications

Telomere Length Attrition, a Marker of Biological Senescence, Is Inversely Correlated with Triglycerides and Cholesterol in South Asian Males with Type 2 Diabetes Mellitus

Telomere Length Attrition, a Marker of Biological Senescence, Is Inversely Correlated with Triglycerides and Cholesterol in South Asian Males with Type 2 Diabetes Mellitus

Cardiovascular Disease in South Asian Migrants

Balancing Efficacy and Tolerability Issues with Statin Therapy— Considerations for the Use of Pitavastatin in Special Patient Populations

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