Dyslipidemia in South Asian patients

Abstract

South Asians around the globe have the highest rates of coronary artery disease (CAD). These rates are 50% to 300% higher than other populations, with a higher risk at younger ages. These high rates of CAD are accompanied by low or similar rates of major traditional risk factors. The prevalence of diabetes is three to six times higher among South Asians than Europeans, Americans, and other Asians but does not explain the "South Asian Paradox." A genetic predisposition to CAD, mediated by high levels of lipoprotein(a), markedly magnifies the adverse effects of traditional risk factors related to lifestyle and best explains the South Asian Paradox. Although the major modifiable risk factors do not fully explain the excess burden of CAD, they are doubly important and remain the foundation of preventive and therapeutic strategies in this population. A more aggressive approach to preventive therapy, especially dyslipidemia, at an earlier age and at a lower threshold is clearly warranted.

Cardiovascular Disease in Bangladesh: A Review

“…76 Liberal use of saturated fats and trans fats, deep frying, reuse of cooking oil, and overcooking leading to destruction of folates may all contribute to dyslipidaemia in this population. 78 Studies exclusively related to dyslipidaemia are sparse in Bangladesh.…”

A community screening plan for the prevalence of some chronic diseases in specified adult populations in Saudi Arabia-II: pre-hypertension and hypertension

“…Apparently, both young-and old-age populations in this area of the world are growing hypertensive. 4,9 Elsewhere, too, there is a growing concern that young adults have a relatively comparable risk of developing cardiovascular events 46,47,48 In the 2008 study to identify the prevalence of pre-HTN/HTN, their risks among recruits in Taif 26 , the recruits' age ranged between 18 and 50y, and more than 70% of them were younger than 40. While 80.3% of this study's cohort had high BP, HTN only involved 19.1% of the 2008-study recruits (17.3% pre-HTN: 1.7% HTN=10.2:1).…”

“…47,48 This study provides that our military community was not immune against the consequences of today's way of life that promotes for technology comfort, little fiber and fast food consumption. The prevalence of pre-HTN/HTN and some associated risks, most of which are modifiable, such as obesity, smoking, and dyslipidemia is rather challenging.…”

Metabolic Syndrome in the Indian Population: Public Health Implications

“…High levels of Lp(a) correlate with the prematurity, severity, extent, and progression of coronary atherosclerosis as well as the occurrence and recurrence of MI among Asian Indians. 13 The CV field has recently shown great interest in the role of inflammation in the development of ASCVD. The basic concept is that atherogenesis represents a state of chronic inflammation.…”