Dyslipidemia in chronic kidney disease excluding diabetic and nephrotic aetiology

Abstract

Background: Dyslipidemia is hypothesized as one of the risk factor of chronic kidney disease and plays an important role in the progression of renal failure. The present study was conducted to assess the association between ratio of TG/HDL-C and CKD and other abnormalities in the lipid profile in CKD patients.Methods: This case-control study was conducted in Government General Hospital from July 2013 to November 2013. 100 patients with CKD were included as study cases. 100 healthy patients from the same hospital, who came with different illness other than the study disease were included as controls. Fasting lipid profile was done – total cholesterol, triglycerides and high-density lipoproteins (HDL) were measured and low-density lipoproteins, & TG/HDL ratio were calculated. Comparison of lipid parameters among study and control groups was done. P value <0.05 was considered as statistically significant.Results: Majority of the study patients were under the age group of 40-50 years. Male dominance (86%) was seen in the study group. The association of HDL, LDL, TGL, TGL/HDL, TC parameters and stages of CKD was observed and found to be statistically significant (p value <0.0001 and <0.05). Comparison of lipid parameters among study and control groups were done and difference was found to be statistically significant (p value <0.0001).Conclusions: Dyslipidemia should be treated in early stages of CKD to prevent secondary complications.