Dyslipidemia and Kidney Stone Risk

Torricelli, Fábio César Miranda; De, Shubha; Gebreselassie, Surafel; Li, Ina; Sarkissian, Carl

doi:10.1016/j.juro.2013.09.022

Cited by 78 publications

(88 citation statements)

References 23 publications

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“…Our findings are consistent with those of previous studies [2][3][4][5] regarding the relationship between urine pH and metabolic parameters. For example, urine pH has been found to be significantly lower in patients with type 2 diabetes than in normal volunteers [2] .…”

Section: Discussionsupporting

confidence: 93%

“…Insulin is known to influence both of these processes [17] , and mechanisms of acid-base homeostasis may be altered in a state of insulin resistance [18] . Considering our data along with those from previous studies [2][3][4][5] , we hypothesize that acidic urine may be a renal manifestation of insulin resistance resulting from MetS.…”

Section: Discussionsupporting

confidence: 75%

“…Recently, a relationship between low urine pH (pH <5.5) and diabetes [2] and insulin resistance [3] had been reported. Obesity, another feature of MetS, is also associated with a low urine pH [4] .…”

Section: Introductionmentioning

confidence: 99%

“…Obesity, another feature of MetS, is also associated with a low urine pH [4] . In addition, non-high-density lipoprotein cholesterol (HDL-C) could have a significant association with a lower urinary pH [3] . In a recent cohort study, it was proposed that low urine pH is a causative and predictive factor for the development of MetS [5] .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Fasting Single-Spot Urine pH Is Associated with Metabolic Syndrome in the Japanese Population

Shimodaira

Okaniwa²,

Nakayama³

2017

Med Princ Pract

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across urine pH categories. Path analysis was used to determine the relationship between MetS and urine pH. Results: Subjects with MetS had significantly lower urine pH (5.9 ± 0.7) than those without MetS (6.0 ± 0.7) ( p < 0.001). Partial correlation analysis showed that systolic and diastolic blood pressure, and triglyceride and fasting plasma glucose levels were negatively correlated with urine pH, while high-density lipoprotein cholesterol was positively correlated with urine pH. Analysis of covariance indicated that urine pH decreased with an increasing number of metabolic abnormalities. Adjusted ORs (95% CI) for the presence of MetS in subjects with urine pH 5.5-6.0 and pH <5.5 were 1.34 (1.04-1.73) and 1.52 (1.09-2.13), respectively (reference: subjects with a urine pH >6.0). Conclusion: The MetS and its components were independently associated with lower urine pH. AbstractObjective: To investigate the relationship between urine pH and metabolic syndrome (MetS) and its components, while controlling for covariates. Subjects and Methods: This crosssectional study was conducted on 5,430 Japanese subjects (4,691 without MetS; 739 with MetS) undergoing health assessments. Partial correlation analysis and analysis of covariance were used for controlling confounding parameters (age, gender, levels of serum uric acid and high-sensitivity C-reactive protein, estimated glomerular filtration rate, and smoking and drinking status). Using multiple logistic regression analyses, adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for MetS incidence were calculated Significance of the Study• In this study, a significant, inverse relationship between urine pH and metabolic syndrome and the number of its components were identified after controlling for confounding factors, including serum uric acid levels. The examination of urine pH could be a practical screening tool for metabolic syndrome.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fasting Single-Spot Urine pH Is Associated with Metabolic Syndrome in the Japanese Population

Shimodaira

Okaniwa²,

Nakayama³

2017

Med Princ Pract

View full text Add to dashboard Cite

show abstract

“…4 Indeed, as the number of components of MetS increases the association with CKD is strenthened. 5 Obesity and MetS are also known to increase the risk of urolithiasis [6][7][8][9] -an independent risk factor for CKD. 10,11 Therefore, MetS patients who form kidney stones have contributing risk factors for CKD.…”

mentioning

confidence: 99%

Shock Wave Lithotripsy Does Not Impair Renal Function in a Swine Model of Metabolic Syndrome

Handa

Johnson

Connors

et al. 2015

Journal of Endourology

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Purpose: To determine whether shock wave lithotripsy (SWL) may be a risk factor for renal functional impairment in a swine model of metabolic syndrome (MetS). Materials and Methods: Nine-month-old female Ossabaw pigs were fed an excess calorie atherogenic diet to induce MetS. At 15 months of age, the MetS pigs were treated with 2000 SWs or an overtreatment dose of 4000 SWs targeted at the upper pole calyx of the left kidney (24 kV at 120 SWs/min using the unmodified Dornier HM3 lithotripter; n = 5-6 per treatment group). Serum creatinine (Cr) and blood urea nitrogen (BUN) levels were measured in conscious pigs before and *60 days after SWL to provide a qualitative assessment of how well both kidneys were filtering (glomerular filtration rate [GFR]). Bilateral renal function was assessed at *65 days post-SWL in anesthetized pigs with GFR and effective renal plasma flow (ERPF) quantified by the renal clearance of inulin and para-amino hippurate, respectively. Results: Cr and BUN values were within normal limits before SWL and remained unchanged after lithotripsy in both the 2000 SW-and 4000 SW-treated pigs. GFR and ERPF of kidneys treated with SWL at either SW dose were similar to the contralateral nontreated kidney. Chronic histological changes in the SW-treated pole of the kidney included interstitial fibrosis, sclerotic glomeruli, and dilated and atrophic tubules. Conclusions: Our results are consistent with the view that a single SWL session does not result in renal impairment, even in the presence of MetS.

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Higher genetically predicted low‐density lipoprotein levels increase the renal cancer risk independent of triglycerides and high‐density lipoprotein levels: A Mendelian randomization study

Jian

Xiang

et al. 2022

Intl Journal of Cancer

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The causation between lipids and renal cancer remains inconclusive. Our purpose is to explore the causal relationships between the three primary lipid metabolism-related substances, namely triglycerides (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) with the risk of renal cancer using Mendelian randomization (MR) methods. Genetic instruments for lipids were acquired from the UK Biobank.Outcome data were from the FinnGen study (1397 renal cancer cases and 204 070).Single-variable MR (SVMR) and multi-variable MR (MVMR) analyses were conducted with TwoSampleMR package based on R 4.0.3. The random-effect inverse-variance weighted (IVW), MR-Egger, weighted-median method, and weighted mode were the four main computing methods. We found that per 1 SD elevated LDL level was causally associated with renal cancer occurrence based on SVMR (OR, 1.31, 95% CI:1.05-1.64, P = .016). Similar significant associations were found in other methods.However, the results of SVMR did not support significant associations between TG, and HDL with renal cancer risk in all methods. The association between LDL and renal cancer was still significant in MVMR analysis (OR for IVW method: 1.22 per 1 SD higher trait (SD, 95% CI: 1.11-1.34, P < .001; OR for MR-Egger: 1.22 per 1 SD higher trait, 95% CI: 1.01-1.47, P = .042) when taking TG and HDL into consideration. Our study supported that elevated serum LDL levels is causally associated with an increased risk of renal cancer independent of TG and HDL.

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Dyslipidemia and Kidney Stone Risk

Abstract: There is a link between dyslipidemia and kidney stone risk that is independent of other components of metabolic syndrome such as diabetes and obesity. Specific alterations in the patient lipid profiles may portend unique aberrations in urine physicochemistry and stone risk.

Cited by 78 publications

References 23 publications

Fasting Single-Spot Urine pH Is Associated with Metabolic Syndrome in the Japanese Population

Fasting Single-Spot Urine pH Is Associated with Metabolic Syndrome in the Japanese Population

Shock Wave Lithotripsy Does Not Impair Renal Function in a Swine Model of Metabolic Syndrome

Higher genetically predicted low‐density lipoprotein levels increase the renal cancer risk independent of triglycerides and high‐density lipoprotein levels: A Mendelian randomization study

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