Dysimmunity in common variable immunodeficiency is associated with alterations in oral, respiratory, and intestinal microbiota

Cabanero-Navalon, Marta Dafne; Garcia-Bustos, Victor; Mira, Alex; Moral Moral, Pedro; Salavert-Lleti, Miguel; Forner Giner, María José; Núñez Beltrán, María; Todolí Parra, José; Bracke, Carme; Carda-Diéguez, Miguel

doi:10.1016/j.clim.2023.109796

Clinical Immunology

2023

DOI: 10.1016/j.clim.2023.109796

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Dysimmunity in common variable immunodeficiency is associated with alterations in oral, respiratory, and intestinal microbiota

Marta Dafne Cabanero-Navalon,

Victor Garcia-Bustos,

Alex Mira

et al.

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2024

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Cited by 2 publications

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Altered oral microbiome, but normal human papilloma virus prevalence in cartilage-hair hypoplasia patients

Arponen,

Vakkilainen,

Tomnikov

et al. 2024

Orphanet J Rare Dis

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Background Cartilage-hair hypoplasia (CHH) is a rare syndromic immunodeficiency with metaphyseal chondrodysplasia and increased risk of malignancy. In this cross-sectional observational study, we examined HPV status and oral microbiome in individuals with CHH. Oral brush samples were collected from 20 individuals with CHH (aged 5–59 years) and 41 controls (1–69 years). Alpha HPVs (43 types) were tested by nested PCR followed by bead-based probe hybridization. Separately, beta-, gamma-, mu- and nu- HPV types were investigated, and a genome-based bacterial microbiome sequencing was performed. Results We found a similar alpha HPV prevalence in individuals with CHH (45%) and controls (36%). The HPV types of individuals with CHH were HPV-16 (25%), 27, 28, and 78, and of controls HPV-3, 16 (21%), 27, and 61. Beta HPV positivity and combined beta/gamma/mu/nu prevalence was detected in 11% and 11% of individuals with CHH and in 5% and 3% of the controls, respectively. Individuals with CHH differed from the controls in bacterial microbiota diversity, richness, and in microbial composition. Individuals with CHH had lower abundance of species Mitsuokella sp000469545, Parascardovia denticolens, Propionibacterium acidifaciens, UMGS1907 sp004151455, Salinicola halophilus, Haemophilus_A paraphrohaemolyticus, Fusobacterium massiliense, and Veillonella parvula, and higher abundance of Slackia exigua. Conclusions Individuals with CHH exhibit similar prevalence of HPV DNA but different bacterial microbiota on their oral mucosa compared to healthy controls. This may partly explain the previously observed high prevalence of oral diseases in CHH, and regular oral examination is warranted.

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Altered oral microbiome, but normal human papilloma virus prevalence in cartilage-hair hypoplasia patients

Arponen,

Vakkilainen,

Tomnikov

et al. 2024

Orphanet J Rare Dis

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Relation between dysbiosis and inborn errors of immunity

Özdemir

2024

World J Methodol

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Inborn errors of immunity (IEI) disorders, formerly primary immune deficiency diseases, are a heterogeneous group of disorders with variable hereditary transitions, clinical manifestations, complications and varying disease severity. Many of the clinical symptoms, signs and complications in IEI patients can be attributed to inflammatory and immune dysregulatory processes due to loss of microbial diversity (dysbiosis). For example, in common variable immunodeficiency patients, the diversity of bacteria, but not fungi, in the gut microbiota has been found to be reduced and significantly altered. Again, this was associated with a more severe disease phenotype. Compromise of the STAT3/Th17 pathway in hyper-IgE syndrome may lead to dysbiosis of the oral microbiota in these patients, causing Candida albicans to switch from commensal to pathogenic. Modification of the microbiota can be used as a therapeutic approach in patients with IEI. Prebiotics, probiotics, postbiotics and fecal microbiota transplantation can be used to restore the balance of the gut microbiota and reduce pathogenicity in IEI patients. Clinical trials are currently underway to understand the impact of this dysbiosis on the phenotype of IEI diseases and its role in their treatment.

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Dysimmunity in common variable immunodeficiency is associated with alterations in oral, respiratory, and intestinal microbiota

Cited by 2 publications

References 45 publications

Altered oral microbiome, but normal human papilloma virus prevalence in cartilage-hair hypoplasia patients

Altered oral microbiome, but normal human papilloma virus prevalence in cartilage-hair hypoplasia patients

Relation between dysbiosis and inborn errors of immunity

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