Dysgonic Fermenter 2 Septicemia

Hicklin, Harry E; Verghese, Abraham; Álvarez, Salvador

doi:10.1093/clinids/9.5.884

Cited by 92 publications

(34 citation statements)

References 39 publications

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“…Previous antimicrobial susceptibility studies have included the first three named species and have shown predictable susceptibility to beta-lactam antibiotics, clindamycin, and the quinolone antibiotics; variable susceptibility to metronidazole; and fairly uniform resistance to aminoglycosides and vancomycin. There are very few reports on the susceptibility patterns of the newer additions to the genus, but the limited data available suggest similar susceptibility patterns (5,16).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial susceptibilities and beta-lactamase characterization of Capnocytophaga species

Roscoe

Zemcov

Thornber

et al. 1992

Antimicrob Agents Chemother

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Capnocytophaga species have been associated with a wide variety of infections in both immunocompetent and immunocompromised patients. On the basis of data from antimicrobial susceptibility studies, beta-lactam antibiotics have been considered efficacious therapy. Six of 19 isolates from primarily clinical sources across Canada demonstrated ,-lactamase production, and agar dilution susceptibility testing showed broad resistance to beta-lactam antibiotics. For the P-lactamase producing isolates, clavulanate reduced the MIC of amoxicillin for 90% of the strains tested by 64-fold. Isolates were highly susceptible to clindamycin, imipenem, and ciprofloxacin. Characterization of the 13-lactamases produced by two of these isolates (Vanl and Van2) was performed. Isoelectric focusing revealed an identical isoelectric point of 5.6 for both enzymes, but they had markedly different relative hydrolysis efficiencies, and different conditions were required to extract the enzymes. This study demonstrates the production of different types of 13-lactamases by Capnocytophaga spp. and suggests the need to screen all clinical isolates of Capnocytophaga spp. for the presence of 13-lactamases.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial susceptibilities and beta-lactamase characterization of Capnocytophaga species

Roscoe

Zemcov

Thornber

et al. 1992

Antimicrob Agents Chemother

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“…It has been recommended that horse blood agar plates with Difco blood agar base 2 support the growth of Capnocytophaga canimorsus better than chocolate agar (178). Examination of the Gram stain of buffy coat preparations or samples obtained from petechial lesions was suggested to be a useful rapid diagnostic test for the identification of Capnocytophaga canimorsus (109,139,158).…”

Section: Mammalsmentioning

confidence: 99%

Microbiology of Animal Bite Wound Infections

2011

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SUMMARY The microbiology of animal bite wound infections in humans is often polymicrobial, with a broad mixture of aerobic and anaerobic microorganisms. Bacteria recovered from infected bite wounds are most often reflective of the oral flora of the biting animal, which can also be influenced by the microbiome of their ingested prey and other foods. Bacteria may also originate from the victim's own skin or the physical environment at the time of injury. Our review has focused on bite wound infections in humans from dogs, cats, and a variety of other animals such as monkeys, bears, pigs, ferrets, horses, sheep, Tasmanian devils, snakes, Komodo dragons, monitor lizards, iguanas, alligators/crocodiles, rats, guinea pigs, hamsters, prairie dogs, swans, and sharks. The medical literature in this area has been made up mostly of small case series or case reports. Very few studies have been systematic and are often limited to dog or cat bite injuries. Limitations of studies include a lack of established or inconsistent criteria for an infected wound and a failure to utilize optimal techniques in pathogen isolation, especially for anaerobic organisms. There is also a lack of an understanding of the pathogenic significance of all cultured organisms. Gathering information and conducting research in a more systematic and methodical fashion through an organized research network, including zoos, veterinary practices, and rural clinics and hospitals, are needed to better define the microbiology of animal bite wound infections in humans.

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“…Rabies is a possibility when a dog bite is sustained abroad or from a quarantined dog. Capnocytophaga canimorsus (previously known as dysgonic fermenter-2; DF-2) is a Gram-negative bacillus that can, rarely, contaminate dog (or cat) bites and may give rise to a rapidly progressive and potentially fatal sepsis syndrome, especially in people who are immunocompromised 3 , 18 , 19…”

Section: Features Of Bites From Mammalsmentioning

confidence: 99%

Managing bites from humans and other mammals

2004

DTB

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Dysgonic Fermenter 2 Septicemia

Cited by 92 publications

References 39 publications

Antimicrobial susceptibilities and beta-lactamase characterization of Capnocytophaga species

Antimicrobial susceptibilities and beta-lactamase characterization of Capnocytophaga species

Microbiology of Animal Bite Wound Infections

Managing bites from humans and other mammals

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