Dysfunctions of cerebral networks precede recognition memory deficits in early Parkinson's disease

Altered functional connectivity in the default mode network is associated with cognitive impairment and brain anatomical changes in Parkinson's disease

“…The areas that have been identified as part of the DMN are the medial prefrontal cortex (MPFC), anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), precuneus, medial temporal lobe (MTL) and inferior parietal cortex (IPC) [8]. The relevance of the DMN has been emphasized in several neuropsychiatric diseases [8], but only a few studies have investigated the DMN in the context of PD [9][10][11][12][13][14] . FMRI studies have confirmed the crucial role played by the DMN in cognitive processing both in normal aging and neurodegenerative disorders [15,16].…”

Functional connectivity in obesity during reward processing

“…The ICA technique has been shown to provide similar results to standard model-based general lineal model approaches (Calhoun et al, 2001) and in some cases it can isolate patterns of activation that cannot be generated by general lineal model approaches . ICA has been used for a variety of task-fMRI studies including those investigating recognition memory (Ibarretxe-Bilbao et al, 2011), verbal generation (Karunanayaka et al, 2010), verbal comprehension (Karunanayaka et al, 2007;Schmithorst et al, 2006), working memory and music perception (Schmithorst, 2005).…”

Resting-State Networks in Alzheimer's Disease and Parkinson's Disease

“…In PD, decreases in functional connectivity were located in the temporoparietal cortex within the DMN. In the same vein, Ibarretxe-Bilbao et al [11] reported decreased DMN deactivations during a recognition memory task in PD patients without evident memory deficit in comparison with HC. The authors concluded that a dysfunction of the DMN might have a role in the development of future cognitive decline in PD.…”

“…The RSNs have been less studied using fMRI in PD and PD-dementia (PDD), but studies have shown rather variable results with regard to changes in the motor and extrastriate visual network as well as in the DMN [6,7,8,9,10,11,12,13]. The following text will briefly touch upon the DMN studies in PD and PDD; it is to a great extent based on the published work of the author.…”