Dysfunctions  associated with dementia and their treatment

Malak, Roksana; Kostiukow, Anna; Krawczyk-Wasielewska, Agnieszka; Keczmer, Przemysław; Mojs, Ewa; Głodowska, Katarzyna; Samborski, Włodzimierz

doi:10.5604/12321966.1129934

Cited by 11 publications

(14 citation statements)

References 9 publications

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“…Therefore, children with balance deficits often have difficulty moving outdoors, which in turn results in decreased independence and limited participation in the community 6–9. However, even children who are able to move in various environments (indoors and outdoors) frequently meet challenges with their balance during such activities 10,11…”

Section: Introductionmentioning

confidence: 99%

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Pediatric Balance Scale: Translation and Cross-Cultural Adaptation Into Greek

Bania,

Gkoutsidou,

Billis

et al. 2023

Pediatric Physical Therapy

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Purpose: Cross-cultural adaptation of the Pediatric Balance Scale (PBS) into Greek. Methods: The PBS was forward-back translated and evaluated for content equivalence. The Greek PBS (PBSGR) was administered to children with movement impairments by 2 pediatric physical therapists. The scale was readministered to the same children after 3 weeks (test-retest reliability) and to children with typical development for discriminant validity. The 1-minute walk test was administered to test the scale's concurrent validity. Results: Psychometric testing was completed on 26 children with movement impairments. The scale had excellent interrater and test-retest reliability and internal consistency. Moderate correlation was observed between PBSGR and 1-minute walk. Children with movement impairment had significantly lower PBSGR scores than children with typical development. Conclusions: Acceptable reliability, concurrent validity, and discriminant validity were observed for the PBSGR.

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Section: Introductionmentioning

confidence: 99%

“…Current evidence: Even children who are able to move in various environments (indoors and outdoors) frequently meet challenges with their balance during outdoor activities,10,11 which in turn results in decreasing their independence and participation in the community.…”

mentioning

confidence: 99%

Pediatric Balance Scale: Translation and Cross-Cultural Adaptation Into Greek

Bania,

Gkoutsidou,

Billis

et al. 2023

Pediatric Physical Therapy

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“…People with DS show a premature or accelerated aging of some body systems (Zigman, 2013), among which the musculoskeletal (Barnhart & Connolly, 2007). Deficit in motor coordination, balance, and postural control (Malak et al, 2013; Rigoldi et al, 2011) as well as severe muscle hypotonia and weakness are typical musculoskeletal abnormalities in DS (Davis & Kelso, 1982; Lagan et al, 2020; Morris et al, 1982). The early development of such physical dysfunctions critically impacts on the quality of daily life and functional capacity of affected people.…”

Section: Introductionmentioning

confidence: 99%

Physical training promotes remodeling of the skeletal muscle extracellular matrix: An ultrastructural study in a murine model of Down syndrome

Cisterna

Boschi

Lacavalla

et al. 2023

Microscopy Res & Technique

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Down syndrome (DS) is a genetically based disease caused by triplication of chromosome 21. DS is characterized by multi‐systemic premature aging associated with deficit in motor coordination, balance, and postural control. Using a morphological, morphometrical, and immunocytochemical ultrastructural approach, this study investigated in vastus lateralis muscle of Ts65Dn mouse, a murine model of DS, the effect of an adapted physical training on the extracellular matrix (ECM) characteristics and whether the forecasted exercise‐induced ECM remodeling impacts on sarcomere organization. Morphometry demonstrated thicker basement membrane and larger collagen bundles with larger interfibrillar spacing as well as irregularly arrayed myofibrils and lower telethonin density on Z‐lines in trisomic versus euploid sedentary mice. In agreement with the multi‐systemic premature aging described in DS, these ECM alterations were similar to those previously observed in skeletal muscle of aged mice. Adapted physical training induced remodeling of ECM in both trisomic and euploid mice, that is, enlargement of the collagen bundles associated with hypertrophy of collagen fibrils and reduction of the interfibrillar spacing. A re‐alignment of the myofibrils and a higher telethonin density on Z‐line was found in trisomic mice. Altogether, our findings suggest that physical training is an effective tool in limiting/counteracting the trisomy‐associated musculoskeletal structural anomalies. The current findings constitute a solid experimental background for further study investigating the possible positive effect of physical training on skeletal muscle performance.Research Highlights Vastus lateralis muscle of trisomic mice shows aging‐like alterations of extracellular matrix. Training promotes extracellular matrix remodeling. Training may be an effective tool to counteract trisomy‐associated alterations of skeletal muscle.

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“…DS, the most prevalent human chromosomal disease (Sherman et al, 2007), is caused by trisomy of chromosome 21. Children and adolescents with DS evince cognitive, neuromotor, and sensory impairments (Patterson et al, 2013) that constrain activities of daily living and participation in community activities (Wuang & Su, 2012) and limitation of motor activities (Malak et al, 2013; Palisano et al, 2001). Sit-to-stand movement (STS) is one of the motor activities in which children with DS experience limitations.…”

mentioning

confidence: 99%

“…Children and adolescents with DS may perform STS with decreased muscle strength , especially in the quadriceps, as this may particularly impact their ability on daily functional activities, (e.g., rising from a chair and walking on the street) (Beqaj et al, 2018; Cowley et al, 2010). Moreover, lower levels of gross motor function are directly related to a worse performance in static and dynamic balance (Beqaj et al, 2018; Malak et al, 2013). Physical and attitudinal environment might also be related to motor and cognitive development (Andrade et al, 2005), and, in children with DS, the physical environment may restrict or facilitate activities of daily living (Foley et al, 2014).…”

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confidence: 99%

Biopsychosocial Factors Related to Postural Sway During Sit-to-Stand Movement in Children and Adolescents With Down Syndrome: A Cross-Sectional Study

et al. 2022

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We investigated factors related to postural sway during sit-to-stand movement in children and adolescents with Down syndrome (DS). Our assessment of participants followed the biopsychosocial model. Body function and structure were represented by muscle strength and postural sway during sit-to-stand movement, which were assessed by manual muscle testing and kinetics analysis, respectively. The Gross Motor Function Measure and Pediatric Balance Scale depicted the activity component. In addition, we included these relevant contextual factors: age, Home Observation for Measurement of the Environment, family income, and maternal schooling. A correlation analysis verified a suspected association between biopsychosocial and postural sway variables. There were significant separated correlations between postural sway in the three phases of the sit-to-stand movement, and age, GMFM-88 dimension D, and muscle strength. Thus, postural control in sit-to-stand movement was related to biopsychosocial factors involving different life aspects of children and adolescents with DS, and these factors should be addressed in rehabilitation therapy intended to improve postural control among these individuals.

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Dysfunctions associated with dementia and their treatment

Cited by 11 publications

References 9 publications

Pediatric Balance Scale: Translation and Cross-Cultural Adaptation Into Greek

Pediatric Balance Scale: Translation and Cross-Cultural Adaptation Into Greek

Physical training promotes remodeling of the skeletal muscle extracellular matrix: An ultrastructural study in a murine model of Down syndrome

Biopsychosocial Factors Related to Postural Sway During Sit-to-Stand Movement in Children and Adolescents With Down Syndrome: A Cross-Sectional Study

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