Dysfunctional high-density lipoproteins in diabetes mellitus

Poteryaeva, O. N.; Usynin, I. F.

doi:10.14341/probl13118

Cited by 6 publications

(1 citation statement)

References 58 publications

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“…Качественные [17,18]. Научные работы, посвященные изучению влияния растворимых пищевых волокон, показали значительное снижение гликированного гемоглобина и уровня глюкозы натощак у лиц с СД 2 типа.…”

Section: макронутриентный составunclassified

Potential of nutrition in body weight improvement in type 2 diabetes

Елиашевич¹,

Drapkina²

2023

Cardiovasc Ther Prev

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Type 2 diabetes (T2D) is a nutritionally dependent disease. Modern scientific data indicate the possibility of remission of T2D by therapeutic nutrition and lifestyle. The results of prospective studies have been accumulated regarding the impact of micro- and macronutrients, individual foods and food systems on the prevention and treatment of T2D. A flexible system for choosing a nutritional model with proven efficacy and safety in T2D can contribute to better glycemic control and body weight correction.

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Section: макронутриентный составunclassified

Potential of nutrition in body weight improvement in type 2 diabetes

Елиашевич¹,

Drapkina²

2023

Cardiovasc Ther Prev

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Possibilities of transition of the strategy from glucosecentricity to organoprotection when prescribing antidiabetic drugs in patients with type 2 diabetes mellitus in the perimenapause

Smirnov,

Semenova,

Shapovalova

et al. 2023

vmirvz

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Obesity, type 2 diabetes mellitus and cardiovascular diseases associated with these conditions remain one of the largest global health problems. According to statistics, at least 90 % of patients with type 2 diabetes mellitus are obese or at least overweight (BMI > 25). Very often, the cause of death in this cohort of patients is the development of a cardiovascular catastrophe. Currently, there is a gradual rejection of the exclusively glucose-centric concept of type 2 diabetes mellitus therapy in favor of an organoprotective one. In this article, we examined the possibility of using various groups of incretinomimetics (DPP-4 inhibitors and GLP-1 agonists) in the primary prevention of cardiovascular diseases in patients with type 2 diabetes mellitus in perimenopause, and comparing their effects with traditional metformin therapy.The aim of the study was to evaluate the effect of non – insulin antidiabetic drugs from the class of incretinomimetics on risk factors for the development of cardiovascular diseases in patients with type 2 diabetes mellitus in perimenopause.Object and methods. A dynamic examination of three groups of patients was carried out. The first group (n = 22) received therapy with the GLP-1 agonist semaglutide, the second group (n = 30) metformin therapy and the third (n = 19) with the DPP-4 inhibitor linagliptin. All patients, in addition to general clinical examination, assessment of the dynamics of weight loss and insulin resistance, underwent a dynamic study of triglyceride levels, low – density lipoprotein cholesterol, as well as markers of general inflammation – C-reactive protein and interleukin-6.Results. The results of the study showed that semaglutide and metformin were equally effective in reducing body weight, but metformin and linagliptin did not significantly affect the level of atherogenic fractions of the lipidogram, unlike semaglutide. Nevertheless, both semaglutide, linagliptin, and metformin reduced the level of markers of general inflammation.Conclusions. The results of the study allow us to discern a certain cardioprotective potential not only in agonists of GLP-1, but also in representatives of the class of DPP-4 inhibitors, which requires further research.

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Assessment of the blood lipid spectrum of workers under stressful conditions labor

Rakhmanov,

Bogomolova,

Razgulin

et al. 2024

Sanitary Doctor

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The importance of dyslipidemia for health lies in the potentiation of cardiovascular diseases. We assessed the blood lipid spectrum and types of dyslipidemia in people with intense work (men aged 35.7 ± 0.8 years, n = 58). Body mass index (BMI) and nutritional status were determined. We assessed working conditions according to the degree of harmfulness and danger. A survey was conducted to establish the fact of tobacco and alcohol consumption. Mental work with high psycho-emotional stress and intensity of the work process in conditions of physical inactivity was assessed as harmful — 3.2. The proportion of smokers was 10.3 %, 100.0 % drank alcohol in moderate doses periodically. Body weight 84.6 ± 1.3 kg, BMI — 26.1 ± 0.3 kg/m2. The proportion of people with overweight and obesity was 68.4 %. Elevated triglycerides (TG) were detected in 17.7 %, total cholesterol (TC) in 60.3 %, low-density lipoproteins (LDL) in 74.0 %, reduced high-density lipoproteins (HDL) in 17.0 %. The atherogenic coefficient (AC) was 3.58 ± 0.13; in 51.8 % it exceeded the normal value. An adequate and inadequate response of the body to living conditions was evidenced by high and low levels of HDL: in 30.2 % and 5.4 % of those examined. The leading type of dyslipidemia was hypercholesterolemia (in 44.6 %). The proportion of mixed and atherogenic was 5.4 % and 1.8 %. In 23.2 %, excess levels of TC, LDL and TG in various combinations were recorded against the background of high HDL; their KA was normal. It can be assumed that physical inactivity against the background of intense work are risk factors for the development of dyslipidemia.

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Dysfunctional high-density lipoproteins in diabetes mellitus

Cited by 6 publications

References 58 publications

Potential of nutrition in body weight improvement in type 2 diabetes

Potential of nutrition in body weight improvement in type 2 diabetes

Possibilities of transition of the strategy from glucosecentricity to organoprotection when prescribing antidiabetic drugs in patients with type 2 diabetes mellitus in the perimenapause

Assessment of the blood lipid spectrum of workers under stressful conditions labor

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