Dysfunction of ventral striatal reward prediction in schizophrenia

Juckel, Georg; Schlagenhauf, Florian; Koslowski, Michael; Wüstenberg, Torsten; Villringer, Arno; Knutson, Brian; Wrase, Jana; Heinz, Andreas

doi:10.1016/j.neuroimage.2005.07.051

Cited by 529 publications

(488 citation statements)

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“…A recent study of untreated patients with schizophrenia revealed decreased differential responses of dopaminergic brain areas when expecting a monetary reward (Juckel et al, 2006b), which normalized with atypical antipsychotic medication (Juckel et al, 2006a). Our study confirms a normal functioning of the reward system in schizophrenia patients medicated with atypical neuroleptics, in contrast to patients with mania who show altered activation patterns despite being medicated with atypical neuroleptics.…”

Section: Expectation Phasesupporting

confidence: 83%

“…(2) Medicated patients during an acute episode of schizophrenia or schizoaffective disorder will not show similarly decreased reward-related brain activation (Juckel et al, 2006b), which provides evidence that the anticipated changes in medicated, manic patients are not simply due to an acute psychiatric illness or due to treatment with neuroleptic medication.…”

Section: Introductionmentioning

confidence: 99%

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Abnormal Reward System Activation in Mania

Abler

Greenhouse

Öngür

et al. 2007

Neuropsychopharmacol

196

137

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Transmission of reward signals is a function of dopamine, a neurotransmitter known to be involved in the mechanism of psychosis. Using functional magnetic resonance imaging (fMRI), we investigated how expectation and receipt of monetary rewards modulate brain activation in patients with bipolar mania and schizophrenia. We studied 12 acutely manic patients with a history of bipolar disorder, 12 patients with a current episode of schizoaffective disorder or schizophrenia and 12 healthy subjects. All patients were treated with dopamine antagonists at the time of the study. Subjects performed a delayed incentive paradigm with monetary reward in the scanner that allowed for investigating effects of expectation, receipt, and omission of rewards. Patients with schizophrenia and healthy control subjects showed the expected activation of dopaminergic brain areas, that is, ventral tegmentum activation upon expectation of monetary rewards and nucleus accumbens activation during receipt vs omission of rewards. In manic patients, however, we did not find a similar pattern of brain activation and the differential signal in the nucleus accumbens upon receipt vs omission of rewards was significantly lower compared to the healthy control subjects. Our findings provide evidence for abnormal function of the dopamine system during receipt or omission of expected rewards in bipolar disorder. These deficits in prediction error processing in acute mania may help to explain symptoms of disinhibition and abnormal goal pursuit regulation.

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Section: Expectation Phasesupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Abnormal Reward System Activation in Mania

Abler

Greenhouse

Öngür

et al. 2007

Neuropsychopharmacol

196

137

View full text Add to dashboard Cite

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“…However, there is also evidence that these effects may be mediated by the predictability or certainty of rewards, as individuals with schizophrenia have reduced activation of the ventral striatum to unexpected reward outcomes, but have enhanced responses to expected rewards [421]. There is also evidence of inverse relations between negative symptoms and NAc activation during reward anticipation [416,420,422] and between lateral PFC activation during reward outcomes [420]. Waltz et al .…”

Section: Reviewmentioning

confidence: 99%

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter

Damiano

Allen

2012

J Neurodevelop Disord

252

207

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This review summarizes evidence of dysregulated reward circuitry function in a range of neurodevelopmental and psychiatric disorders and genetic syndromes. First, the contribution of identifying a core mechanistic process across disparate disorders to disease classification is discussed, followed by a review of the neurobiology of reward circuitry. We next consider preclinical animal models and clinical evidence of reward-pathway dysfunction in a range of disorders, including psychiatric disorders (i.e., substance-use disorders, affective disorders, eating disorders, and obsessive compulsive disorders), neurodevelopmental disorders (i.e., schizophrenia, attention-deficit/hyperactivity disorder, autism spectrum disorders, Tourette’s syndrome, conduct disorder/oppositional defiant disorder), and genetic syndromes (i.e., Fragile X syndrome, Prader–Willi syndrome, Williams syndrome, Angelman syndrome, and Rett syndrome). We also provide brief overviews of effective psychopharmacologic agents that have an effect on the dopamine system in these disorders. This review concludes with methodological considerations for future research designed to more clearly probe reward-circuitry dysfunction, with the ultimate goal of improved intervention strategies.

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“…A recent study (Juckel et al, 2006b) reported that unmedicated patients with schizophrenia showed reduced ventral striatal activation during presentation of reward-predicting cues. Another study focusing on the effect generated by the rewarding experience rather than reward anticipation, showed that patients rated the hedonic value of the pleasant odors lower than controls and also failed to activate limbic/paralimbic structures invoked by normal controls (Crespo-Facorro et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…While these studies do make a case for some kind of a reward abnormality in schizophrenia (eg Juckel et al, 2006b), they did not obtain any online objective measures of reward-learning, which could link the behavior and brain dysfunction to the disease. Therefore, in this study, we wanted to investigate whether patient's with schizophrenia showed aberrant learning when exposed to motivationally salient (aversive in this case) stimuli.…”

Section: Introductionmentioning

confidence: 99%

The Formation of Abnormal Associations in Schizophrenia: Neural and Behavioral Evidence

Jensen

Willeit

Zipursky

et al. 2007

Neuropsychopharmacol

204

155

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It is hypothesized that due to an abnormal functioning of the reward system patients with schizophrenia form context-inappropriate associations. It has been shown that the dopamine target regions, especially the ventral striatum, are critical in the formation of reward associations. We wanted to examine how the ventral striatum responds as patients learn reward-related associations and how this neural response is linked to objective and subjective behavioral measures. Functional magnetic resonance imaging (fMRI) Blood oxygen level dependent (BOLD) responses were examined using aversive Pavlovian learning in 13 medicated patients with schizophrenia and 13 matched healthy controls. Colored circles served as conditioned stimulus (CS + ) while a loud, individually adjusted, noise served as the unconditioned stimulus. Circles of another color served as neutral comparators (CSÀ). Subjective indices were assessed by a post-scan self-report, and galvanic skin responses (GSR) were used as objective measures of associative learning. fMRI data were analyzed using a random effects model in SPM2. Patients showed inappropriately strong activations in the ventral striatum in response to the neutral stimulus (CSÀ) as compared to the healthy controls. Consistent with this neural evidence of aberrant learning, patients also showed evidence of abnormal learning by self-report and as indexed by GSR. The main finding here is that patients with schizophrenia, when exposed to neutral stimuli in a threatening situation, show an abnormal pattern of learning. The aberrant activations and response are consistent with the idea that patients aberrantly assign motivational salience to neutral stimuli, and this process may be one of the aberrations that predisposes them to psychosis.

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Dysfunction of ventral striatal reward prediction in schizophrenia

Cited by 529 publications

References 50 publications

Abnormal Reward System Activation in Mania

Abnormal Reward System Activation in Mania

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

The Formation of Abnormal Associations in Schizophrenia: Neural and Behavioral Evidence

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